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Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans.
Nutr Rev. 2011 Mar; 69(3):145-54.NR

Abstract

Calorie restriction (CR)-induced weight loss has been shown to lower the risk of chronic disease in obese individuals. Although the mechanisms that link weight loss to disease risk reduction remain unclear, evidence suggests adipokines may play a role. What has yet to be determined, however, is the dose-response effect of body weight loss and visceral fat mass loss on adipokines. Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). The dose-response relationship between visceral fat mass loss and adipokine profile improvement will also be explored. Results from this review demonstrate that even mild weight loss induced by CR may have beneficial effects on leptin levels, but it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1, or RBP-4 concentrations.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA. varady@uic.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21348878

Citation

Klempel, Monica C., and Krista A. Varady. "Reliability of Leptin, but Not Adiponectin, as a Biomarker for Diet-induced Weight Loss in Humans." Nutrition Reviews, vol. 69, no. 3, 2011, pp. 145-54.
Klempel MC, Varady KA. Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans. Nutr Rev. 2011;69(3):145-54.
Klempel, M. C., & Varady, K. A. (2011). Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans. Nutrition Reviews, 69(3), 145-54. https://doi.org/10.1111/j.1753-4887.2011.00373.x
Klempel MC, Varady KA. Reliability of Leptin, but Not Adiponectin, as a Biomarker for Diet-induced Weight Loss in Humans. Nutr Rev. 2011;69(3):145-54. PubMed PMID: 21348878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans. AU - Klempel,Monica C, AU - Varady,Krista A, Y1 - 2011/02/14/ PY - 2011/2/26/entrez PY - 2011/2/26/pubmed PY - 2011/4/5/medline SP - 145 EP - 54 JF - Nutrition reviews JO - Nutr Rev VL - 69 IS - 3 N2 - Calorie restriction (CR)-induced weight loss has been shown to lower the risk of chronic disease in obese individuals. Although the mechanisms that link weight loss to disease risk reduction remain unclear, evidence suggests adipokines may play a role. What has yet to be determined, however, is the dose-response effect of body weight loss and visceral fat mass loss on adipokines. Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). The dose-response relationship between visceral fat mass loss and adipokine profile improvement will also be explored. Results from this review demonstrate that even mild weight loss induced by CR may have beneficial effects on leptin levels, but it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1, or RBP-4 concentrations. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/21348878/Reliability_of_leptin_but_not_adiponectin_as_a_biomarker_for_diet_induced_weight_loss_in_humans_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2011.00373.x DB - PRIME DP - Unbound Medicine ER -