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High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers.

Abstract

The purpose of the present study was to determine the influence of the glycaemic index (GI) and glycaemic load (GL) on the ratio of tryptophan (TRP) relative to other large neutral amino acids (LNAA). Ten healthy men (age 22·9 (sd 3·4) years; BMI 23·5 (sd 1·6) kg/m2) underwent standard GI testing, and later consumed each of a mixed-macronutrient (1915 kJ; 66·5 % carbohydrate (CHO), 17 % protein and 16·5 % fat) high-GI (MHGI), an isoenergetic, mixed-macronutrient low-GI (MLGI) and a CHO-only (3212 kJ; 90 % CHO, 8 % protein, 2 % fat) high-GI (CHGI) meal on separate days. The GI, GL and insulin index values (e.g. area under the curve) were largest after the CHGI meal (117, 200, 158), followed by the MHGI (79, 59, 82) and MLGI (51, 38, 56) meals, respectively (all values were significantly different, P < 0·05). After the MHGI and MLGI meals but not after the CHGI meal, TRP was elevated at 120 and 180 min (P < 0·05). After the CHGI, LNAA was lower compared with the MLGI (P < 0·05); also the rate of decline in LNAA was higher after CHGI compared with MHGI and MLGI (both comparisons P < 0·05). The percentage increase from baseline in TRP:LNAA after CHGI (23 %) was only marginally higher than after the MHGI meal (17 %; P = 0·38), but it was threefold and nearly significantly greater than MLGI (8 %; P = 0·05). The present study demonstrates that the postprandial rise in TRP:LNAA was increased by additional CHO ingestion and higher GI. Therefore, the meal GL appears to be an important factor influencing the postprandial TRP:LNAA concentration.

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  • Authors+Show Affiliations

    ,

    Discipline of Exercise and Sport Science, Faculty of Health Sciences, University of Sydney, Sydney, NSW, Australia. christopher.herrera@aspetar.com

    , , , , ,

    Source

    The British journal of nutrition 105:11 2011 Jun pg 1601-6

    MeSH

    Adult
    Amino Acids
    Biological Availability
    Blood Glucose
    Dietary Carbohydrates
    Food Analysis
    Glycemic Index
    Humans
    Insulin
    Male
    Postprandial Period
    Satiety Response
    Sleep Stages
    Tryptophan
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21349213

    Citation

    Herrera, Christopher P., et al. "High-glycaemic Index and -glycaemic Load Meals Increase the Availability of Tryptophan in Healthy Volunteers." The British Journal of Nutrition, vol. 105, no. 11, 2011, pp. 1601-6.
    Herrera CP, Smith K, Atkinson F, et al. High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers. Br J Nutr. 2011;105(11):1601-6.
    Herrera, C. P., Smith, K., Atkinson, F., Ruell, P., Chow, C. M., O'Connor, H., & Brand-Miller, J. (2011). High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers. The British Journal of Nutrition, 105(11), pp. 1601-6. doi:10.1017/S0007114510005192.
    Herrera CP, et al. High-glycaemic Index and -glycaemic Load Meals Increase the Availability of Tryptophan in Healthy Volunteers. Br J Nutr. 2011;105(11):1601-6. PubMed PMID: 21349213.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers. AU - Herrera,Christopher P, AU - Smith,Keir, AU - Atkinson,Fiona, AU - Ruell,Patricia, AU - Chow,Chin Moi, AU - O'Connor,Helen, AU - Brand-Miller,Jennie, Y1 - 2011/02/24/ PY - 2011/2/26/entrez PY - 2011/2/26/pubmed PY - 2011/8/30/medline SP - 1601 EP - 6 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 105 IS - 11 N2 - The purpose of the present study was to determine the influence of the glycaemic index (GI) and glycaemic load (GL) on the ratio of tryptophan (TRP) relative to other large neutral amino acids (LNAA). Ten healthy men (age 22·9 (sd 3·4) years; BMI 23·5 (sd 1·6) kg/m2) underwent standard GI testing, and later consumed each of a mixed-macronutrient (1915 kJ; 66·5 % carbohydrate (CHO), 17 % protein and 16·5 % fat) high-GI (MHGI), an isoenergetic, mixed-macronutrient low-GI (MLGI) and a CHO-only (3212 kJ; 90 % CHO, 8 % protein, 2 % fat) high-GI (CHGI) meal on separate days. The GI, GL and insulin index values (e.g. area under the curve) were largest after the CHGI meal (117, 200, 158), followed by the MHGI (79, 59, 82) and MLGI (51, 38, 56) meals, respectively (all values were significantly different, P < 0·05). After the MHGI and MLGI meals but not after the CHGI meal, TRP was elevated at 120 and 180 min (P < 0·05). After the CHGI, LNAA was lower compared with the MLGI (P < 0·05); also the rate of decline in LNAA was higher after CHGI compared with MHGI and MLGI (both comparisons P < 0·05). The percentage increase from baseline in TRP:LNAA after CHGI (23 %) was only marginally higher than after the MHGI meal (17 %; P = 0·38), but it was threefold and nearly significantly greater than MLGI (8 %; P = 0·05). The present study demonstrates that the postprandial rise in TRP:LNAA was increased by additional CHO ingestion and higher GI. Therefore, the meal GL appears to be an important factor influencing the postprandial TRP:LNAA concentration. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21349213/High_glycaemic_index_and__glycaemic_load_meals_increase_the_availability_of_tryptophan_in_healthy_volunteers_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510005192/type/journal_article DB - PRIME DP - Unbound Medicine ER -