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A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly.
World J Gastroenterol. 2011 Feb 07; 17(5):651-6.WJ

Abstract

AIM

To evaluate the possibility of an association between polyethylene glycol (PEG) and acute renal failure (ARF) in elderly patients using a health insurance claims database.

METHODS

We conducted a population-based case-crossover study using information obtained from Korean Health Insurance Review and Assessment Service (HIRA) claims from January 1, 2005 to December 31, 2005 (Seoul, Korea). The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1, 2005 to December 31, 2005. For each patient, one case and two control periods were matched. PEG use in a 2- or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2- or 4-wk control window periods. Conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% CI, adjusting for concomitant uses of diuretics, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antibiotics, anti-cancer drugs, and contrast media.

RESULTS

Within the HIRA database which contained 1,093,262 elderly patients, 1156 hospitalized ARF cases were identified. Among these cases, PEG was prescribed to 17 (1.5%) patients before hospitalization. The adjusted ORs when applying the 2- and 4-wk window periods were 0.4 (95% CI: 0.03-5.24) and 2.1 (95% CI: 0.16-27.78), respectively.

CONCLUSION

No increased risk of ARF was found in elderly PEG users. However, based on the limited number of study subjects, further analysis should be performed to confirm these results.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, and Department of Occupational Medicine, Health Screening Center, Kangbuk Samsung Hospital, Seoul 110-799, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21350715

Citation

Choi, Nam-Kyong, et al. "A Population-based Case-crossover Study of Polyethylene Glycol Use and Acute Renal Failure Risk in the Elderly." World Journal of Gastroenterology, vol. 17, no. 5, 2011, pp. 651-6.
Choi NK, Chang Y, Jung SY, et al. A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly. World J Gastroenterol. 2011;17(5):651-6.
Choi, N. K., Chang, Y., Jung, S. Y., Choi, Y. K., Lee, J., Lee, J. H., Kim, J. Y., & Park, B. J. (2011). A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly. World Journal of Gastroenterology, 17(5), 651-6. https://doi.org/10.3748/wjg.v17.i5.651
Choi NK, et al. A Population-based Case-crossover Study of Polyethylene Glycol Use and Acute Renal Failure Risk in the Elderly. World J Gastroenterol. 2011 Feb 7;17(5):651-6. PubMed PMID: 21350715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A population-based case-crossover study of polyethylene glycol use and acute renal failure risk in the elderly. AU - Choi,Nam-Kyong, AU - Chang,Yoosoo, AU - Jung,Sun-Young, AU - Choi,Yu-Kyong, AU - Lee,Joongyub, AU - Lee,Jin-Ho, AU - Kim,Ju-Young, AU - Park,Byung-Joo, PY - 2010/10/05/received PY - 2010/11/03/revised PY - 2010/11/10/accepted PY - 2011/2/26/entrez PY - 2011/2/26/pubmed PY - 2011/7/19/medline KW - Acute renal failure KW - Adverse drug reaction KW - Case-crossover KW - Health insurance claims database KW - Polyethylene glycol SP - 651 EP - 6 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 17 IS - 5 N2 - AIM: To evaluate the possibility of an association between polyethylene glycol (PEG) and acute renal failure (ARF) in elderly patients using a health insurance claims database. METHODS: We conducted a population-based case-crossover study using information obtained from Korean Health Insurance Review and Assessment Service (HIRA) claims from January 1, 2005 to December 31, 2005 (Seoul, Korea). The study population consisted of elderly patients who received PEG prior to experiencing their first ARF-related hospitalization from April 1, 2005 to December 31, 2005. For each patient, one case and two control periods were matched. PEG use in a 2- or 4-wk window period prior to hospitalization for ARF was compared with PEG use in two earlier 2- or 4-wk control window periods. Conditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% CI, adjusting for concomitant uses of diuretics, angiotensin converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, antibiotics, anti-cancer drugs, and contrast media. RESULTS: Within the HIRA database which contained 1,093,262 elderly patients, 1156 hospitalized ARF cases were identified. Among these cases, PEG was prescribed to 17 (1.5%) patients before hospitalization. The adjusted ORs when applying the 2- and 4-wk window periods were 0.4 (95% CI: 0.03-5.24) and 2.1 (95% CI: 0.16-27.78), respectively. CONCLUSION: No increased risk of ARF was found in elderly PEG users. However, based on the limited number of study subjects, further analysis should be performed to confirm these results. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/21350715/A_population_based_case_crossover_study_of_polyethylene_glycol_use_and_acute_renal_failure_risk_in_the_elderly_ L2 - https://www.wjgnet.com/1007-9327/full/v17/i5/651.htm DB - PRIME DP - Unbound Medicine ER -