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Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis.
Early Interv Psychiatry. 2008 Nov; 2(4):277-84.EI

Abstract

AIM

Based on previous reports of second-generation antipsychotic agents having a beneficial effect on prodromal symptoms, we investigated the effectiveness and tolerability of atypical antipsychotic therapies in individuals at high risk for developing psychosis.

METHODS

We examined prodromal symptoms and functioning in individuals at ultra-high-risk for psychosis using an uncontrolled prospective design with pre- and post-treatment measures.

RESULTS

Of the 27 subjects taking antipsychotics during the study period, 15 took part in at least one follow-up assessment. Overall Comprehensive Assessment of At-Risk Mental States scores significantly improved at the last evaluation point, with a medium-size effect of Cohen's d = 0.54 (95% confidence interval, -0.02 to 1.08) (mean follow-up period = 8.8; SD = 8.3 months). Depression and anxiety symptoms were markedly reduced, and global and social functioning also significantly improved. Of the 27 subjects, two (7.4%) converted to psychosis and 16 (59.3%) experienced at least one treatment-emergent adverse event, but no subjects exhibited serious adverse events.

CONCLUSIONS

The results of this study support treating high-risk individuals with antipsychotics to reduce prodromal symptoms with adequate safety.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Shim G
Department of Psychiatry, Seoul National University, College of Medicine, Clinical Cognitive Neuroscience Center, Neuroscience Institute, SNU-MRC, Chongno-gu, Seoul, Korea.
Kang DH
No affiliation info available
Choi JS
No affiliation info available
Jung MH
No affiliation info available
Kwon SJ
No affiliation info available
Jang GE
No affiliation info available
Kwon JS
No affiliation info available

MeSH

Antipsychotic AgentsEarly DiagnosisFemaleHumansMaleProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersRisk FactorsSchizophreniaStatistics, NonparametricTreatment OutcomeYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21352161

Citation

Shim, GeumSook, et al. "Prospective Outcome of Early Intervention for Individuals at Ultra-high-risk for Psychosis." Early Intervention in Psychiatry, vol. 2, no. 4, 2008, pp. 277-84.
Shim G, Kang DH, Choi JS, et al. Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis. Early Interv Psychiatry. 2008;2(4):277-84.
Shim, G., Kang, D. H., Choi, J. S., Jung, M. H., Kwon, S. J., Jang, G. E., & Kwon, J. S. (2008). Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis. Early Intervention in Psychiatry, 2(4), 277-84. https://doi.org/10.1111/j.1751-7893.2008.00089.x
Shim G, et al. Prospective Outcome of Early Intervention for Individuals at Ultra-high-risk for Psychosis. Early Interv Psychiatry. 2008;2(4):277-84. PubMed PMID: 21352161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective outcome of early intervention for individuals at ultra-high-risk for psychosis. AU - Shim,GeumSook, AU - Kang,Do-Hyung, AU - Choi,Jung-Seok, AU - Jung,Myung Hun, AU - Kwon,Soo Jin, AU - Jang,Go Eun, AU - Kwon,Jun Soo, PY - 2011/3/1/entrez PY - 2008/11/1/pubmed PY - 2011/6/22/medline SP - 277 EP - 84 JF - Early intervention in psychiatry JO - Early Interv Psychiatry VL - 2 IS - 4 N2 - AIM: Based on previous reports of second-generation antipsychotic agents having a beneficial effect on prodromal symptoms, we investigated the effectiveness and tolerability of atypical antipsychotic therapies in individuals at high risk for developing psychosis. METHODS: We examined prodromal symptoms and functioning in individuals at ultra-high-risk for psychosis using an uncontrolled prospective design with pre- and post-treatment measures. RESULTS: Of the 27 subjects taking antipsychotics during the study period, 15 took part in at least one follow-up assessment. Overall Comprehensive Assessment of At-Risk Mental States scores significantly improved at the last evaluation point, with a medium-size effect of Cohen's d = 0.54 (95% confidence interval, -0.02 to 1.08) (mean follow-up period = 8.8; SD = 8.3 months). Depression and anxiety symptoms were markedly reduced, and global and social functioning also significantly improved. Of the 27 subjects, two (7.4%) converted to psychosis and 16 (59.3%) experienced at least one treatment-emergent adverse event, but no subjects exhibited serious adverse events. CONCLUSIONS: The results of this study support treating high-risk individuals with antipsychotics to reduce prodromal symptoms with adequate safety. SN - 1751-7893 UR - https://www.unboundmedicine.com/medline/citation/21352161/Prospective_outcome_of_early_intervention_for_individuals_at_ultra_high_risk_for_psychosis_ DB - PRIME DP - Unbound Medicine ER -