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Iodine removal in intravenous dual-energy CT-cholangiography: is virtual non-enhanced imaging effective to replace true non-enhanced imaging?
Eur J Radiol. 2012 Apr; 81(4):692-9.EJ

Abstract

PURPOSE

To evaluate whether virtual non-enhanced imaging (VNI) is effective to replace true non-enhanced imaging (TNI) applying iodine removal in intravenous dual-energy CT-cholangiography.

MATERIALS AND METHODS

From April 2009 until February 2010, fifteen potential donors for living-related liver transplantation (mean age 37.6±10.8 years) were included. Potential donors underwent a two-phase CT-examination of the liver. The first phase consisted of a single-energy non-enhanced CT-acquisition that provided TNI. After administration of hepatobiliary contrast agent, the second phase was performed as a dual-energy cholangiographic CT-acquisition. This provided VNI. Objective image quality (attenuation values [bile ducts and liver parenchyma] and contrast-to-noise ratio) and subjective overall image quality (1 - excellent; 5 - non diagnostic) were evaluated. Effective radiation dose was compared.

RESULTS

For TNI and VNI, attenuation values for bile ducts were 16.8±11.2HU and 5.5±17.0HU (p<0.05) and for liver parenchyma 55.3±8.4HU and 58.1±10.6HU (n.s.). For TNI and VNI, contrast-to-noise ratio was 2.6±0.6HU and 6.9±2.1HU (p<0.001). For VNI, subjective overall image quality was 1 in ten datasets, 2 in four datasets and 3 in one dataset. Effective radiation dose for the dual-energy cholangiographic CT-acquisition was 3.6±0.9mSv and for two-phase single-energy CT-cholangiography 5.1±1.3mSv (p<0.001).

CONCLUSION

In this study on iodine removal in intravenous dual-energy CT-cholangiography, subjective image quality is equivalent, contrast-to-noise ratio is improved and effective radiation dose is reduced when VNI is performed. The differences between TNI and VNI with respect to attenuation values seem to have limited clinical relevance and therefore we consider VNI as effective to replace TNI.

Authors+Show Affiliations

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany. cmsommer@gmx.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21353419

Citation

Sommer, Christof M., et al. "Iodine Removal in Intravenous Dual-energy CT-cholangiography: Is Virtual Non-enhanced Imaging Effective to Replace True Non-enhanced Imaging?" European Journal of Radiology, vol. 81, no. 4, 2012, pp. 692-9.
Sommer CM, Schwarzwaelder CB, Stiller W, et al. Iodine removal in intravenous dual-energy CT-cholangiography: is virtual non-enhanced imaging effective to replace true non-enhanced imaging? Eur J Radiol. 2012;81(4):692-9.
Sommer, C. M., Schwarzwaelder, C. B., Stiller, W., Schindera, S. T., Stampfl, U., Bellemann, N., Holzschuh, M., Schmidt, J., Weitz, J., Grenacher, L., Kauczor, H. U., & Radeleff, B. A. (2012). Iodine removal in intravenous dual-energy CT-cholangiography: is virtual non-enhanced imaging effective to replace true non-enhanced imaging? European Journal of Radiology, 81(4), 692-9. https://doi.org/10.1016/j.ejrad.2011.01.087
Sommer CM, et al. Iodine Removal in Intravenous Dual-energy CT-cholangiography: Is Virtual Non-enhanced Imaging Effective to Replace True Non-enhanced Imaging. Eur J Radiol. 2012;81(4):692-9. PubMed PMID: 21353419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iodine removal in intravenous dual-energy CT-cholangiography: is virtual non-enhanced imaging effective to replace true non-enhanced imaging? AU - Sommer,Christof M, AU - Schwarzwaelder,Christoph B, AU - Stiller,Wolfram, AU - Schindera,Sebastian T, AU - Stampfl,Ulrike, AU - Bellemann,Nadine, AU - Holzschuh,Maria, AU - Schmidt,Jan, AU - Weitz,Juergen, AU - Grenacher,Lars, AU - Kauczor,Hans U, AU - Radeleff,Boris A, Y1 - 2011/02/24/ PY - 2010/12/28/received PY - 2011/01/20/accepted PY - 2011/3/1/entrez PY - 2011/3/1/pubmed PY - 2012/7/17/medline SP - 692 EP - 9 JF - European journal of radiology JO - Eur J Radiol VL - 81 IS - 4 N2 - PURPOSE: To evaluate whether virtual non-enhanced imaging (VNI) is effective to replace true non-enhanced imaging (TNI) applying iodine removal in intravenous dual-energy CT-cholangiography. MATERIALS AND METHODS: From April 2009 until February 2010, fifteen potential donors for living-related liver transplantation (mean age 37.6±10.8 years) were included. Potential donors underwent a two-phase CT-examination of the liver. The first phase consisted of a single-energy non-enhanced CT-acquisition that provided TNI. After administration of hepatobiliary contrast agent, the second phase was performed as a dual-energy cholangiographic CT-acquisition. This provided VNI. Objective image quality (attenuation values [bile ducts and liver parenchyma] and contrast-to-noise ratio) and subjective overall image quality (1 - excellent; 5 - non diagnostic) were evaluated. Effective radiation dose was compared. RESULTS: For TNI and VNI, attenuation values for bile ducts were 16.8±11.2HU and 5.5±17.0HU (p<0.05) and for liver parenchyma 55.3±8.4HU and 58.1±10.6HU (n.s.). For TNI and VNI, contrast-to-noise ratio was 2.6±0.6HU and 6.9±2.1HU (p<0.001). For VNI, subjective overall image quality was 1 in ten datasets, 2 in four datasets and 3 in one dataset. Effective radiation dose for the dual-energy cholangiographic CT-acquisition was 3.6±0.9mSv and for two-phase single-energy CT-cholangiography 5.1±1.3mSv (p<0.001). CONCLUSION: In this study on iodine removal in intravenous dual-energy CT-cholangiography, subjective image quality is equivalent, contrast-to-noise ratio is improved and effective radiation dose is reduced when VNI is performed. The differences between TNI and VNI with respect to attenuation values seem to have limited clinical relevance and therefore we consider VNI as effective to replace TNI. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/21353419/Iodine_removal_in_intravenous_dual_energy_CT_cholangiography:_is_virtual_non_enhanced_imaging_effective_to_replace_true_non_enhanced_imaging L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(11)00127-6 DB - PRIME DP - Unbound Medicine ER -