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Feasibility of endoscopic closure of an iatrogenic colon perforation occurring during colonoscopy.
Gastrointest Endosc. 2011 Mar; 73(3):550-5.GE

Abstract

BACKGROUND

Colon perforation is one of the most dreaded complications of colonoscopy. Traditionally, patients with a colon perforation have been treated surgically. Although there are several case reports documenting the usefulness of endoscopic closure of colon perforations, there are few current data evaluating the feasibility of endoscopic closure for an iatrogenic perforation on consecutive patients undergoing colonoscopy.

OBJECTIVE

To assess the incidence of colon perforations and the utility of immediate endoscopic closure during colonoscopy.

DESIGN

Retrospective, observational study.

SETTING

Tertiary-care academic medical center.

PATIENTS

All patients who underwent colonoscopy at 1 institution from June 2002 to December 2008 were identified.

INTERVENTION

An attempt at immediate colon perforation closure by endoscopic means.

MAIN OUTCOME MEASUREMENTS

Successful endoscopic closure of colon perforation.

RESULTS

During the study period, a total of 8601 colonoscopies were performed (2472 therapeutic interventions, 28.7%). A total of 12 iatrogenic colon perforations occurred, yielding a rate of 1.4/1000. Five (41.7%) occurred during a diagnostic colonoscopy (0.8/1000), and 7 perforations (58.3%) occurred as the result of a therapeutic intervention (2.8/1000). Endoscopic closure of the perforation site was possible in 5 patients (42%). Seven patients were treated surgically (large defects [n = 3], including 1 failed endoscopic closure, difficult endoscope position [n = 2], stool contamination [n = 1], and endoscopist's inexperience with closure of mucosal defects [n = 1]).

LIMITATION

Retrospective design.

CONCLUSIONS

In this study, the incidence of colon perforations was 1.4/1000. Endoscopic closure of iatrogenic colon perforations was attempted in 50% of patients and was successful in 83%. All patients with successful endoscopic closure had lesions smaller than 10 mm.

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Authors+Show Affiliations

Jovanovic I
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Zimmermann L
No affiliation info available
Fry LC
No affiliation info available
Mönkemüller K
No affiliation info available

MeSH

AdultAgedChi-Square DistributionClinical CompetenceColonColonoscopyFeasibility StudiesFemaleHumansIncidenceIntestinal PerforationMaleMiddle AgedRetrospective StudiesSurgical InstrumentsTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21353851

Citation

Jovanovic, Ivan, et al. "Feasibility of Endoscopic Closure of an Iatrogenic Colon Perforation Occurring During Colonoscopy." Gastrointestinal Endoscopy, vol. 73, no. 3, 2011, pp. 550-5.
Jovanovic I, Zimmermann L, Fry LC, et al. Feasibility of endoscopic closure of an iatrogenic colon perforation occurring during colonoscopy. Gastrointest Endosc. 2011;73(3):550-5.
Jovanovic, I., Zimmermann, L., Fry, L. C., & Mönkemüller, K. (2011). Feasibility of endoscopic closure of an iatrogenic colon perforation occurring during colonoscopy. Gastrointestinal Endoscopy, 73(3), 550-5. https://doi.org/10.1016/j.gie.2010.12.026
Jovanovic I, et al. Feasibility of Endoscopic Closure of an Iatrogenic Colon Perforation Occurring During Colonoscopy. Gastrointest Endosc. 2011;73(3):550-5. PubMed PMID: 21353851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Feasibility of endoscopic closure of an iatrogenic colon perforation occurring during colonoscopy. AU - Jovanovic,Ivan, AU - Zimmermann,Lars, AU - Fry,Lucia C, AU - Mönkemüller,Klaus, PY - 2010/10/22/received PY - 2010/12/28/accepted PY - 2011/3/1/entrez PY - 2011/3/1/pubmed PY - 2011/7/23/medline SP - 550 EP - 5 JF - Gastrointestinal endoscopy JO - Gastrointest Endosc VL - 73 IS - 3 N2 - BACKGROUND: Colon perforation is one of the most dreaded complications of colonoscopy. Traditionally, patients with a colon perforation have been treated surgically. Although there are several case reports documenting the usefulness of endoscopic closure of colon perforations, there are few current data evaluating the feasibility of endoscopic closure for an iatrogenic perforation on consecutive patients undergoing colonoscopy. OBJECTIVE: To assess the incidence of colon perforations and the utility of immediate endoscopic closure during colonoscopy. DESIGN: Retrospective, observational study. SETTING: Tertiary-care academic medical center. PATIENTS: All patients who underwent colonoscopy at 1 institution from June 2002 to December 2008 were identified. INTERVENTION: An attempt at immediate colon perforation closure by endoscopic means. MAIN OUTCOME MEASUREMENTS: Successful endoscopic closure of colon perforation. RESULTS: During the study period, a total of 8601 colonoscopies were performed (2472 therapeutic interventions, 28.7%). A total of 12 iatrogenic colon perforations occurred, yielding a rate of 1.4/1000. Five (41.7%) occurred during a diagnostic colonoscopy (0.8/1000), and 7 perforations (58.3%) occurred as the result of a therapeutic intervention (2.8/1000). Endoscopic closure of the perforation site was possible in 5 patients (42%). Seven patients were treated surgically (large defects [n = 3], including 1 failed endoscopic closure, difficult endoscope position [n = 2], stool contamination [n = 1], and endoscopist's inexperience with closure of mucosal defects [n = 1]). LIMITATION: Retrospective design. CONCLUSIONS: In this study, the incidence of colon perforations was 1.4/1000. Endoscopic closure of iatrogenic colon perforations was attempted in 50% of patients and was successful in 83%. All patients with successful endoscopic closure had lesions smaller than 10 mm. SN - 1097-6779 UR - https://www.unboundmedicine.com/medline/citation/21353851/Feasibility_of_endoscopic_closure_of_an_iatrogenic_colon_perforation_occurring_during_colonoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(10)02501-0 DB - PRIME DP - Unbound Medicine ER -