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Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper.
Comp Biochem Physiol C Toxicol Pharmacol. 2011 Jun; 154(1):56-63.CB

Abstract

This study aimed to assess the antioxidant system potential and lipid peroxidative effects, in the gill and digestive gland of Mytilus galloprovincialis exposed to individual and binary mixtures of benzo(a)pyrene (BaP) and Cu for 7 days. Data demonstrated that in mussels exposed to BaP antioxidant enzymes (catalase--CAT, total glutathione peroxidase--tGPx, glutathione S-transferase--GST and glutathione reductase--GR) and lipid peroxidation (LPO) increased in the gill. On the contrary, in the digestive gland inhibitory antioxidant effects (superoxide dismutase-SOD, GR, metallothioneins-MT) and no changes in LPO levels were detected. Cu was also a potent oxidant agent since MT and LPO levels increased in mussel gill, despite no LPO effect in the digestive gland. For both single contaminants the organ specificity and distinct physiologic/metabolism roles were evident in terms of antioxidant capacity. Gill SOD inhibition, MT and GST unchanged was a result of "simple independent action" of exposure to BaP and Cu. "Interactions" in the binary mixtures, led to absence of changes in LPO effects. In the digestive gland, BaP and Cu interactions were also responsible for the GST and LPO enhancement (antagonistic effects). The current findings demonstrate the differences in antioxidant responses where the organ dependency highlights each contaminant particular mode of action. Generally, in the gill "non-interactive" effects occurred with the lowest Cu concentration while "interactions" exist for the mixture with the highest Cu concentrations. In the digestive gland, "interactions" and "no interaction" effects occurred in all the binary mixtures. Complex contaminant mixtures interact differently based on target tissue which may lead to an imbalance in the mussels health status.

Authors+Show Affiliations

University of Algarve & CIMA, 8005-139 Faro, Portugal.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21354328

Citation

Maria, V L., and M J. Bebianno. "Antioxidant and Lipid Peroxidation Responses in Mytilus Galloprovincialis Exposed to Mixtures of Benzo(a)pyrene and Copper." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 154, no. 1, 2011, pp. 56-63.
Maria VL, Bebianno MJ. Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper. Comp Biochem Physiol C Toxicol Pharmacol. 2011;154(1):56-63.
Maria, V. L., & Bebianno, M. J. (2011). Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 154(1), 56-63. https://doi.org/10.1016/j.cbpc.2011.02.004
Maria VL, Bebianno MJ. Antioxidant and Lipid Peroxidation Responses in Mytilus Galloprovincialis Exposed to Mixtures of Benzo(a)pyrene and Copper. Comp Biochem Physiol C Toxicol Pharmacol. 2011;154(1):56-63. PubMed PMID: 21354328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper. AU - Maria,V L, AU - Bebianno,M J, Y1 - 2011/02/24/ PY - 2010/11/08/received PY - 2011/02/15/revised PY - 2011/02/15/accepted PY - 2011/3/1/entrez PY - 2011/3/1/pubmed PY - 2011/9/29/medline SP - 56 EP - 63 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 154 IS - 1 N2 - This study aimed to assess the antioxidant system potential and lipid peroxidative effects, in the gill and digestive gland of Mytilus galloprovincialis exposed to individual and binary mixtures of benzo(a)pyrene (BaP) and Cu for 7 days. Data demonstrated that in mussels exposed to BaP antioxidant enzymes (catalase--CAT, total glutathione peroxidase--tGPx, glutathione S-transferase--GST and glutathione reductase--GR) and lipid peroxidation (LPO) increased in the gill. On the contrary, in the digestive gland inhibitory antioxidant effects (superoxide dismutase-SOD, GR, metallothioneins-MT) and no changes in LPO levels were detected. Cu was also a potent oxidant agent since MT and LPO levels increased in mussel gill, despite no LPO effect in the digestive gland. For both single contaminants the organ specificity and distinct physiologic/metabolism roles were evident in terms of antioxidant capacity. Gill SOD inhibition, MT and GST unchanged was a result of "simple independent action" of exposure to BaP and Cu. "Interactions" in the binary mixtures, led to absence of changes in LPO effects. In the digestive gland, BaP and Cu interactions were also responsible for the GST and LPO enhancement (antagonistic effects). The current findings demonstrate the differences in antioxidant responses where the organ dependency highlights each contaminant particular mode of action. Generally, in the gill "non-interactive" effects occurred with the lowest Cu concentration while "interactions" exist for the mixture with the highest Cu concentrations. In the digestive gland, "interactions" and "no interaction" effects occurred in all the binary mixtures. Complex contaminant mixtures interact differently based on target tissue which may lead to an imbalance in the mussels health status. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/21354328/Antioxidant_and_lipid_peroxidation_responses_in_Mytilus_galloprovincialis_exposed_to_mixtures_of_benzo_a_pyrene_and_copper_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(11)00020-2 DB - PRIME DP - Unbound Medicine ER -