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Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders.
J Feline Med Surg 2011; 13(4):237-43JF

Abstract

The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats. Cats received either meloxicam (0.5mg/ml oral suspension) at 0.1mg/kg on day 1 followed by 0.05mg/kg q 24h on days 2-5, or ketoprofen 5mg tablets at 1.0mg/kg q 24h for 5 days. The efficacy of the two treatments was assessed subjectively by clinicians on day 6 using a clinical sum score (CSS). Palatability and accuracy of dosing were also assessed. The baseline CSS was not significantly different between the groups, and after 5 days of treatment the CSS had decreased to a similar extent, reflecting a reduction in pain. There were no significant differences between the CSS of each group at day 6. Both treatments were well tolerated. Meloxicam was significantly more palatable than ketoprofen, and allowed for more accurate dosing. Meloxicam and ketoprofen are a safe and efficacious treatment for acute locomotor disorders in cats. Meloxicam (Metacam) may be associated with superior compliance in clinical practice due to the higher palatability, which results in better ease of administration.

Authors+Show Affiliations

University of Edinburgh, Easter Bush, Midlothian, UK. laura.johnston@boehringeringelheim.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

21354843

Citation

Morton, Carolyn M., et al. "Clinical Evaluation of Meloxicam Versus Ketoprofen in Cats Suffering From Painful Acute Locomotor Disorders." Journal of Feline Medicine and Surgery, vol. 13, no. 4, 2011, pp. 237-43.
Morton CM, Grant D, Johnston L, et al. Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. J Feline Med Surg. 2011;13(4):237-43.
Morton, C. M., Grant, D., Johnston, L., Letellier, I. M., & Narbe, R. (2011). Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. Journal of Feline Medicine and Surgery, 13(4), pp. 237-43. doi:10.1016/j.jfms.2010.09.018.
Morton CM, et al. Clinical Evaluation of Meloxicam Versus Ketoprofen in Cats Suffering From Painful Acute Locomotor Disorders. J Feline Med Surg. 2011;13(4):237-43. PubMed PMID: 21354843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of meloxicam versus ketoprofen in cats suffering from painful acute locomotor disorders. AU - Morton,Carolyn M, AU - Grant,Debbie, AU - Johnston,Laura, AU - Letellier,Ingrid M, AU - Narbe,Ruediger, Y1 - 2011/02/26/ PY - 2010/09/22/accepted PY - 2011/3/1/entrez PY - 2011/3/1/pubmed PY - 2011/5/7/medline SP - 237 EP - 43 JF - Journal of feline medicine and surgery JO - J. Feline Med. Surg. VL - 13 IS - 4 N2 - The aim of this study was to evaluate the efficacy and palatability of meloxicam 0.5mg/ml oral suspension, compared to ketoprofen tablets in cats suffering from painful acute locomotor disorders. This single blinded, positively-controlled, randomised, multicentre trial involved 121 client owned cats. Cats received either meloxicam (0.5mg/ml oral suspension) at 0.1mg/kg on day 1 followed by 0.05mg/kg q 24h on days 2-5, or ketoprofen 5mg tablets at 1.0mg/kg q 24h for 5 days. The efficacy of the two treatments was assessed subjectively by clinicians on day 6 using a clinical sum score (CSS). Palatability and accuracy of dosing were also assessed. The baseline CSS was not significantly different between the groups, and after 5 days of treatment the CSS had decreased to a similar extent, reflecting a reduction in pain. There were no significant differences between the CSS of each group at day 6. Both treatments were well tolerated. Meloxicam was significantly more palatable than ketoprofen, and allowed for more accurate dosing. Meloxicam and ketoprofen are a safe and efficacious treatment for acute locomotor disorders in cats. Meloxicam (Metacam) may be associated with superior compliance in clinical practice due to the higher palatability, which results in better ease of administration. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/21354843/Clinical_evaluation_of_meloxicam_versus_ketoprofen_in_cats_suffering_from_painful_acute_locomotor_disorders_ L2 - http://journals.sagepub.com/doi/full/10.1016/j.jfms.2010.09.018?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -