[Anti-HBV constituents from Euphorbia fischeriana].
Zhongguo Zhong Yao Za Zhi. 2010 Nov; 35(22):3002-6.ZZ

Abstract

OBJECTIVE

To investigate the anti-HBV constituents in the roots of Euphorbia fischeriana.

METHOD

The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity.

RESULT

Eleven compounds were isolated and identified as tirucalla-5,24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7) helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside (11).

CONCLUSION

Compounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity.

Authors+Show Affiliations

Yu M

School of Pharmacy, Fudan University, Shanghai 201203, China.

Hou A

No affiliation info available

MeSH

Antiviral AgentsDrugs, Chinese HerbalEuphorbiaHepatitis B virusPlant Roots

Pub Type(s)

English Abstract

Journal Article

Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21355270

Citation

Yu, Meihua, and Aijun Hou. "[Anti-HBV Constituents From Euphorbia Fischeriana]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 35, no. 22, 2010, pp. 3002-6.

Yu M, Hou A. [Anti-HBV constituents from Euphorbia fischeriana]. Zhongguo Zhong Yao Za Zhi. 2010;35(22):3002-6.

Yu, M., & Hou, A. (2010). [Anti-HBV constituents from Euphorbia fischeriana]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 35(22), 3002-6.

Yu M, Hou A. [Anti-HBV Constituents From Euphorbia Fischeriana]. Zhongguo Zhong Yao Za Zhi. 2010;35(22):3002-6. PubMed PMID: 21355270.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - [Anti-HBV constituents from Euphorbia fischeriana]. AU - Yu,Meihua, AU - Hou,Aijun, PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/3/23/medline SP - 3002 EP - 6 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 35 IS - 22 N2 - OBJECTIVE: To investigate the anti-HBV constituents in the roots of Euphorbia fischeriana. METHOD: The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity. RESULT: Eleven compounds were isolated and identified as tirucalla-5,24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7) helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside (11). CONCLUSION: Compounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/21355270/[Anti_HBV_constituents_from_Euphorbia_fischeriana]_ DB - PRIME DP - Unbound Medicine ER -

Tags

[Anti-HBV constituents from Euphorbia fischeriana].Zhongguo Zhong Yao Za Zhi. 2010 Nov; 35(22):3002-6.ZZ