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Cadmium-induced oxidative stress in Saccharomyces cerevisiae.
Indian J Biochem Biophys. 2010 Dec; 47(6):383-7.IJ

Abstract

The present study was undertaken to determine the effect of cadmium (Cd) on the antioxidant status of the yeast Saccharomyces cerevisiae. S. cerevisiae serves as a good eukaryotic model system for the study of the molecular mechanisms of oxidative stress. We investigated the adaptative response of S. cerevisiae exposed to Cd. Yeast cells could tolerate up to 100 microM Cd and an inhibition in the growth and viability was observed. Exposure of yeast cells to Cd showed an increase in malondialdehyde and glutathione. The activities of catalase, superoxide dismutase and glutathione peroxidase were also high in Cd-exposed cells. The incorporation of Cd led to significant increase in iron, zinc and inversely the calcium, copper levels were reduced. The results suggest that antioxidants were increased and are involved in the protection against macromolecular damage during oxidative stress; presumably, these enzymes are essential for counteracting the pro-oxidant effects of Cd.

Authors+Show Affiliations

Department of Biochemistry, School of Life Sciences, Bharathidasan University Tiruchirappalli 620 024, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21355423

Citation

Muthukumar, Kannan, and Vasanthi Nachiappan. "Cadmium-induced Oxidative Stress in Saccharomyces Cerevisiae." Indian Journal of Biochemistry & Biophysics, vol. 47, no. 6, 2010, pp. 383-7.
Muthukumar K, Nachiappan V. Cadmium-induced oxidative stress in Saccharomyces cerevisiae. Indian J Biochem Biophys. 2010;47(6):383-7.
Muthukumar, K., & Nachiappan, V. (2010). Cadmium-induced oxidative stress in Saccharomyces cerevisiae. Indian Journal of Biochemistry & Biophysics, 47(6), 383-7.
Muthukumar K, Nachiappan V. Cadmium-induced Oxidative Stress in Saccharomyces Cerevisiae. Indian J Biochem Biophys. 2010;47(6):383-7. PubMed PMID: 21355423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cadmium-induced oxidative stress in Saccharomyces cerevisiae. AU - Muthukumar,Kannan, AU - Nachiappan,Vasanthi, PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/3/16/medline SP - 383 EP - 7 JF - Indian journal of biochemistry & biophysics JO - Indian J Biochem Biophys VL - 47 IS - 6 N2 - The present study was undertaken to determine the effect of cadmium (Cd) on the antioxidant status of the yeast Saccharomyces cerevisiae. S. cerevisiae serves as a good eukaryotic model system for the study of the molecular mechanisms of oxidative stress. We investigated the adaptative response of S. cerevisiae exposed to Cd. Yeast cells could tolerate up to 100 microM Cd and an inhibition in the growth and viability was observed. Exposure of yeast cells to Cd showed an increase in malondialdehyde and glutathione. The activities of catalase, superoxide dismutase and glutathione peroxidase were also high in Cd-exposed cells. The incorporation of Cd led to significant increase in iron, zinc and inversely the calcium, copper levels were reduced. The results suggest that antioxidants were increased and are involved in the protection against macromolecular damage during oxidative stress; presumably, these enzymes are essential for counteracting the pro-oxidant effects of Cd. SN - 0301-1208 UR - https://www.unboundmedicine.com/medline/citation/21355423/Cadmium_induced_oxidative_stress_in_Saccharomyces_cerevisiae_ L2 - https://antibodies.cancer.gov/detail/CPTC-CTLA4-1 DB - PRIME DP - Unbound Medicine ER -