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CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters.
J Affect Disord. 2011 Jul; 132(1-2):173-8.JA

Abstract

BACKGROUND

Serotonin is implicated in impaired impulse control, aggression and suicidal behaviour. Low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been found in violent suicide attempters, suicide victims and in violent offenders. CSF 5-HIAA concentrations have both genetic and environmental determinants. Childhood trauma may have an effect on central monoamine function as an adult.

AIM

The aim of this study was to assess the relationship of CSF 5-HIAA and the exposure to and the expression of violence in childhood and during adult life measured with the Karolinska Interpersonal Violence Scale (KIVS).

METHOD

42 medication free suicide attempters underwent lumbar puncture and were assessed with the Karolinska Interpersonal Violence Scale (KIVS) to assess history of childhood exposure to violence and lifetime expressed violent behaviour.

RESULTS

In women, but not in men, CSF 5-HIAA showed a significant negative correlation to exposure to violence during childhood. Furthermore, suicide attempters with low CSF 5-HIAA were more prone to commit violent acts as an adult if exposed to violence as a child compared to suicide attempters with high CSF 5-HIAA. In the non-traumatized group, CSF 5-HIAA showed a significant negative correlation to expressed violent behaviour in childhood.

CONCLUSIONS

Although central serotonergic function has important genetic determinants, exposure to childhood trauma may also affect serotonergic function. Low serotonergic function may facilitate impaired aggression control in traumatized suicide attempters.

Authors+Show Affiliations

The Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21356560

Citation

Moberg, T, et al. "CSF 5-HIAA and Exposure to and Expression of Interpersonal Violence in Suicide Attempters." Journal of Affective Disorders, vol. 132, no. 1-2, 2011, pp. 173-8.
Moberg T, Nordström P, Forslund K, et al. CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters. J Affect Disord. 2011;132(1-2):173-8.
Moberg, T., Nordström, P., Forslund, K., Kristiansson, M., Asberg, M., & Jokinen, J. (2011). CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters. Journal of Affective Disorders, 132(1-2), 173-8. https://doi.org/10.1016/j.jad.2011.01.018
Moberg T, et al. CSF 5-HIAA and Exposure to and Expression of Interpersonal Violence in Suicide Attempters. J Affect Disord. 2011;132(1-2):173-8. PubMed PMID: 21356560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CSF 5-HIAA and exposure to and expression of interpersonal violence in suicide attempters. AU - Moberg,T, AU - Nordström,P, AU - Forslund,K, AU - Kristiansson,M, AU - Asberg,M, AU - Jokinen,J, Y1 - 2011/02/26/ PY - 2010/12/28/received PY - 2011/01/30/revised PY - 2011/01/30/accepted PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/11/2/medline SP - 173 EP - 8 JF - Journal of affective disorders JO - J Affect Disord VL - 132 IS - 1-2 N2 - BACKGROUND: Serotonin is implicated in impaired impulse control, aggression and suicidal behaviour. Low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been found in violent suicide attempters, suicide victims and in violent offenders. CSF 5-HIAA concentrations have both genetic and environmental determinants. Childhood trauma may have an effect on central monoamine function as an adult. AIM: The aim of this study was to assess the relationship of CSF 5-HIAA and the exposure to and the expression of violence in childhood and during adult life measured with the Karolinska Interpersonal Violence Scale (KIVS). METHOD: 42 medication free suicide attempters underwent lumbar puncture and were assessed with the Karolinska Interpersonal Violence Scale (KIVS) to assess history of childhood exposure to violence and lifetime expressed violent behaviour. RESULTS: In women, but not in men, CSF 5-HIAA showed a significant negative correlation to exposure to violence during childhood. Furthermore, suicide attempters with low CSF 5-HIAA were more prone to commit violent acts as an adult if exposed to violence as a child compared to suicide attempters with high CSF 5-HIAA. In the non-traumatized group, CSF 5-HIAA showed a significant negative correlation to expressed violent behaviour in childhood. CONCLUSIONS: Although central serotonergic function has important genetic determinants, exposure to childhood trauma may also affect serotonergic function. Low serotonergic function may facilitate impaired aggression control in traumatized suicide attempters. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/21356560/CSF_5_HIAA_and_exposure_to_and_expression_of_interpersonal_violence_in_suicide_attempters_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(11)00051-6 DB - PRIME DP - Unbound Medicine ER -