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Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis.
Retina. 2011 Jul-Aug; 31(7):1316-22.R

Abstract

PURPOSE

To determine the long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes for intravitreal injection.

METHODS

Experimental study. Vancomycin 1 mg/0.1 mL, ceftazidime 2 mg/0.1 mL, and moxifloxacin 160 μg/0.1 mL were compounded and prepared in 1-mL polypropylene syringes and stored at 4 °C, -20 °C, and -80 °C. Antibiotic potency, sterility, pH, osmolality, and concentration were tested at baseline and at 1, 2, 4, 8, 12, and 24 weeks after preparation.

RESULTS

Potency, sterility, and stability were preserved for all 3 antibiotics at all temperatures out to 24 weeks, although there was a trend toward reduced potency at Week 24 for vancomycin and ceftazidime stored at 4°C. The largest zones of inhibition for Staphylococcus epidermidis and S. aureus were consistently demonstrated by moxifloxacin.

CONCLUSION

Vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes retain potency, sterility, and stability out to 24 weeks when stored at -20 °C or -80 °C. The results of this study may have important implications for the current management of endophthalmitis.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Nashville, Tennessee 37232, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21358364

Citation

Mehta, Sachin, et al. "Long-term Potency, Sterility, and Stability of Vancomycin, Ceftazidime, and Moxifloxacin for Treatment of Bacterial Endophthalmitis." Retina (Philadelphia, Pa.), vol. 31, no. 7, 2011, pp. 1316-22.
Mehta S, Armstrong BK, Kim SJ, et al. Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. Retina (Philadelphia, Pa). 2011;31(7):1316-22.
Mehta, S., Armstrong, B. K., Kim, S. J., Toma, H., West, J. N., Yin, H., Lu, P., Wayman, L. L., Recchia, F. M., & Sternberg, P. (2011). Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. Retina (Philadelphia, Pa.), 31(7), 1316-22. https://doi.org/10.1097/IAE.0b013e31820039af
Mehta S, et al. Long-term Potency, Sterility, and Stability of Vancomycin, Ceftazidime, and Moxifloxacin for Treatment of Bacterial Endophthalmitis. Retina (Philadelphia, Pa). 2011 Jul-Aug;31(7):1316-22. PubMed PMID: 21358364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. AU - Mehta,Sachin, AU - Armstrong,Brian K, AU - Kim,Stephen J, AU - Toma,Hassanain, AU - West,Janice N, AU - Yin,Huiyong, AU - Lu,Pengcheng, AU - Wayman,Laura L, AU - Recchia,Franco M, AU - Sternberg,Paul,Jr PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/12/15/medline SP - 1316 EP - 22 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 31 IS - 7 N2 - PURPOSE: To determine the long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes for intravitreal injection. METHODS: Experimental study. Vancomycin 1 mg/0.1 mL, ceftazidime 2 mg/0.1 mL, and moxifloxacin 160 μg/0.1 mL were compounded and prepared in 1-mL polypropylene syringes and stored at 4 °C, -20 °C, and -80 °C. Antibiotic potency, sterility, pH, osmolality, and concentration were tested at baseline and at 1, 2, 4, 8, 12, and 24 weeks after preparation. RESULTS: Potency, sterility, and stability were preserved for all 3 antibiotics at all temperatures out to 24 weeks, although there was a trend toward reduced potency at Week 24 for vancomycin and ceftazidime stored at 4°C. The largest zones of inhibition for Staphylococcus epidermidis and S. aureus were consistently demonstrated by moxifloxacin. CONCLUSION: Vancomycin, ceftazidime, and moxifloxacin prepared in single-use polypropylene syringes retain potency, sterility, and stability out to 24 weeks when stored at -20 °C or -80 °C. The results of this study may have important implications for the current management of endophthalmitis. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/21358364/Long_term_potency_sterility_and_stability_of_vancomycin_ceftazidime_and_moxifloxacin_for_treatment_of_bacterial_endophthalmitis_ L2 - http://dx.doi.org/10.1097/IAE.0b013e31820039af DB - PRIME DP - Unbound Medicine ER -