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Administration of the combination clonazepam-Deanxit as treatment for tinnitus.
Otol Neurotol. 2011 Jun; 32(4):701-9.ON

Abstract

HYPOTHESIS

Present study investigates the combination of Deanxit and clonazepam (Rivotril) intake for relief of tinnitus complaints, respecting a double-blind placebo-controlled approach for Deanxit in a crossover setup.

BACKGROUND

Although several pharmacologic treatments--including antidepressants, prostaglandins, and aminobutyric acid (GABA)-active drugs--were already presented as promising in tinnitus treatment, no drug has yet been approved by the Food and Drug Administration and European Medicine Agency for the treatment of tinnitus.

METHODS

Patients were randomly assigned to patient group A or patient group B in a double-blind way. Patient group A first received 3 weeks of Deanxit, followed by 1 week of washout and 3 weeks of placebo. Treatment was given in opposite order to subjects from Patient group B.All patients received a daily treatment consisting of clonazepam 1 mg once daily, starting on Day 1.

RESULTS

Significant tinnitus reduction was seen after intake of the combination clonazepam-Deanxit, whereas no differences in tinnitus could be demonstrated after the administration of clonazepam-placebo. This was true for all patients according to the following parameters: time patients are annoyed by the tinnitus (p = 0.026) and the visual analogue scale for tinnitus annoyance (p = 0.024).

CONCLUSION

Although tinnitus reduction was recorded as modest, this article provides valuable data demonstrating a placebo-controlled tinnitus reduction after clonazepam and Deanxit intake.

Authors+Show Affiliations

University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital (UZA), University of Antwerp, Antwerp, Belgium. oliviermeeus@uza.beNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21358561

Citation

Meeus, Olivier, et al. "Administration of the Combination clonazepam-Deanxit as Treatment for Tinnitus." Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, vol. 32, no. 4, 2011, pp. 701-9.
Meeus O, De Ridder D, Van de Heyning P. Administration of the combination clonazepam-Deanxit as treatment for tinnitus. Otol Neurotol. 2011;32(4):701-9.
Meeus, O., De Ridder, D., & Van de Heyning, P. (2011). Administration of the combination clonazepam-Deanxit as treatment for tinnitus. Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 32(4), 701-9. https://doi.org/10.1097/MAO.0b013e31820e737c
Meeus O, De Ridder D, Van de Heyning P. Administration of the Combination clonazepam-Deanxit as Treatment for Tinnitus. Otol Neurotol. 2011;32(4):701-9. PubMed PMID: 21358561.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of the combination clonazepam-Deanxit as treatment for tinnitus. AU - Meeus,Olivier, AU - De Ridder,Dirk, AU - Van de Heyning,Paul, PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/12/13/medline SP - 701 EP - 9 JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology JO - Otol. Neurotol. VL - 32 IS - 4 N2 - HYPOTHESIS: Present study investigates the combination of Deanxit and clonazepam (Rivotril) intake for relief of tinnitus complaints, respecting a double-blind placebo-controlled approach for Deanxit in a crossover setup. BACKGROUND: Although several pharmacologic treatments--including antidepressants, prostaglandins, and aminobutyric acid (GABA)-active drugs--were already presented as promising in tinnitus treatment, no drug has yet been approved by the Food and Drug Administration and European Medicine Agency for the treatment of tinnitus. METHODS: Patients were randomly assigned to patient group A or patient group B in a double-blind way. Patient group A first received 3 weeks of Deanxit, followed by 1 week of washout and 3 weeks of placebo. Treatment was given in opposite order to subjects from Patient group B.All patients received a daily treatment consisting of clonazepam 1 mg once daily, starting on Day 1. RESULTS: Significant tinnitus reduction was seen after intake of the combination clonazepam-Deanxit, whereas no differences in tinnitus could be demonstrated after the administration of clonazepam-placebo. This was true for all patients according to the following parameters: time patients are annoyed by the tinnitus (p = 0.026) and the visual analogue scale for tinnitus annoyance (p = 0.024). CONCLUSION: Although tinnitus reduction was recorded as modest, this article provides valuable data demonstrating a placebo-controlled tinnitus reduction after clonazepam and Deanxit intake. SN - 1537-4505 UR - https://www.unboundmedicine.com/medline/citation/21358561/Administration_of_the_combination_clonazepam_Deanxit_as_treatment_for_tinnitus_ L2 - http://dx.doi.org/10.1097/MAO.0b013e31820e737c DB - PRIME DP - Unbound Medicine ER -