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Osteoporosis in anorexia nervosa.
Eat Disord 2011 Mar-Apr; 19(2):194-202ED

Abstract

Osteoporosis is common in anorexia nervosa. It places these patients at increased lifetime risk for fractures. Bone loss may never recover completely even once weight is restored. The strongest predictors of osteoporosis include low body weight and amenorrhea. Loss of bone density can occur rapidly and very early in the course of anorexia nervosa. The etiology of bone loss in the patient with anorexia nervosa is multifactorial. In addition to reduced estrogen and progesterone, excess cortisol levels and low levels of insulin growth factor (IGF-1), a correlate for bone formation, are observed. Dual energy x-ray absorptiometry screening is important to assess bone density. However, successful treatments to reverse bone loss, in those with anorexia nervosa, are lacking. Early diagnosis and treatment of anorexia nervosa are paramount to prevent initial weight loss and subsequent loss of bone.

Authors+Show Affiliations

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA. pmehler@dhha.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21360368

Citation

Mehler, Philip S., et al. "Osteoporosis in Anorexia Nervosa." Eating Disorders, vol. 19, no. 2, 2011, pp. 194-202.
Mehler PS, Cleary BS, Gaudiani JL. Osteoporosis in anorexia nervosa. Eat Disord. 2011;19(2):194-202.
Mehler, P. S., Cleary, B. S., & Gaudiani, J. L. (2011). Osteoporosis in anorexia nervosa. Eating Disorders, 19(2), pp. 194-202. doi:10.1080/10640266.2011.551636.
Mehler PS, Cleary BS, Gaudiani JL. Osteoporosis in Anorexia Nervosa. Eat Disord. 2011;19(2):194-202. PubMed PMID: 21360368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis in anorexia nervosa. AU - Mehler,Philip S, AU - Cleary,Barbara S, AU - Gaudiani,Jennifer L, PY - 2011/3/2/entrez PY - 2011/3/2/pubmed PY - 2011/7/5/medline SP - 194 EP - 202 JF - Eating disorders JO - Eat Disord VL - 19 IS - 2 N2 - Osteoporosis is common in anorexia nervosa. It places these patients at increased lifetime risk for fractures. Bone loss may never recover completely even once weight is restored. The strongest predictors of osteoporosis include low body weight and amenorrhea. Loss of bone density can occur rapidly and very early in the course of anorexia nervosa. The etiology of bone loss in the patient with anorexia nervosa is multifactorial. In addition to reduced estrogen and progesterone, excess cortisol levels and low levels of insulin growth factor (IGF-1), a correlate for bone formation, are observed. Dual energy x-ray absorptiometry screening is important to assess bone density. However, successful treatments to reverse bone loss, in those with anorexia nervosa, are lacking. Early diagnosis and treatment of anorexia nervosa are paramount to prevent initial weight loss and subsequent loss of bone. SN - 1532-530X UR - https://www.unboundmedicine.com/medline/citation/21360368/Osteoporosis_in_anorexia_nervosa_ L2 - http://www.tandfonline.com/doi/full/10.1080/10640266.2011.551636 DB - PRIME DP - Unbound Medicine ER -