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In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats.
Acta Physiol Pol. 1990 Nov-Dec; 41(7):76-84.AP

Abstract

The present report indicates that 2-deoxy-D-glucose (2-DG) at a single dose causing reduction of Tre has no influence on liver and skeletal muscle content of ATP, ADP and AMP, the ATP/ADP ratio, energy charge potential (ECP) and total adenine nucleotides (TAN). After administration of 2-DG for 3) successive days, the level of ATP, ATP/ADP ratio, the values of ECP and TAN are decreased both in the liver and skeletal muscle. However, 72 hours after the last injection of 2-DG adenine nucleotide contents returned to the values observed in control group, indicating that the in vivo effect of this glucose analogue is fully reversible.

Authors+Show Affiliations

Torlińska T
Department of Physiology, Poznań Academy of Medicine.
Rutkowska D
No affiliation info available
Hryniewiecki T
No affiliation info available
Paluszak J
No affiliation info available

MeSH

Adenine NucleotidesAdenosine DiphosphateAdenosine MonophosphateAdenosine TriphosphateAnimalsDeoxyglucoseDose-Response Relationship, DrugEnergy MetabolismLiverMaleMusclesRatsRats, Inbred StrainsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2136320

Citation

Torlińska, T, et al. "In Vivo Effect of 2-deoxy-D-glucose On Adenine Nucleotide Levels in the Liver and Skeletal Muscle of Rats." Acta Physiologica Polonica, vol. 41, no. 7, 1990, pp. 76-84.
Torlińska T, Rutkowska D, Hryniewiecki T, et al. In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats. Acta Physiol Pol. 1990;41(7):76-84.
Torlińska, T., Rutkowska, D., Hryniewiecki, T., & Paluszak, J. (1990). In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats. Acta Physiologica Polonica, 41(7), 76-84.
Torlińska T, et al. In Vivo Effect of 2-deoxy-D-glucose On Adenine Nucleotide Levels in the Liver and Skeletal Muscle of Rats. Acta Physiol Pol. 1990 Nov-Dec;41(7):76-84. PubMed PMID: 2136320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo effect of 2-deoxy-D-glucose on adenine nucleotide levels in the liver and skeletal muscle of rats. AU - Torlińska,T, AU - Rutkowska,D, AU - Hryniewiecki,T, AU - Paluszak,J, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 76 EP - 84 JF - Acta physiologica Polonica JO - Acta Physiol Pol VL - 41 IS - 7 N2 - The present report indicates that 2-deoxy-D-glucose (2-DG) at a single dose causing reduction of Tre has no influence on liver and skeletal muscle content of ATP, ADP and AMP, the ATP/ADP ratio, energy charge potential (ECP) and total adenine nucleotides (TAN). After administration of 2-DG for 3) successive days, the level of ATP, ATP/ADP ratio, the values of ECP and TAN are decreased both in the liver and skeletal muscle. However, 72 hours after the last injection of 2-DG adenine nucleotide contents returned to the values observed in control group, indicating that the in vivo effect of this glucose analogue is fully reversible. SN - 0044-6033 UR - https://www.unboundmedicine.com/medline/citation/2136320/In_vivo_effect_of_2_deoxy_D_glucose_on_adenine_nucleotide_levels_in_the_liver_and_skeletal_muscle_of_rats_ DB - PRIME DP - Unbound Medicine ER -