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Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial.
J Refract Surg. 2011 Aug; 27(8):613-7.JR

Abstract

PURPOSE

To determine whether treatment with oral gabapentin reduces postoperative pain after photorefractive keratectomy (PRK).

METHODS

This prospective, randomized, double-blind, placebo-controlled study comprised 40 patients scheduled for bilateral PRK. Exclusion criteria were previous refractive surgery; diseases that could affect epithelial healing; use of antihistamines, nonsteroidal anti-inflammatory drugs, or steroids; and use of mitomycin C during PRK. Patients were divided into two groups: 20 patients received gabapentin capsules (300 mg) and 20 patients received identical placebo capsules. Visual acuity, slit-lamp examination, and a 12-question, 10-point visual numerical scale questionnaire were evaluated at each postoperative follow-up. Main outcome measures were the severity of pain at each follow-up and during the previous 24 hours. Secondary outcome measures were maximum and minimum severity of pain, healing time, uncorrected distance visual acuity, and the rating of other symptoms and potential side effects.

RESULTS

The gabapentin group had less pain during the first 72 hours (P=.024 to .001). A significant difference in favor of gabapentin was found for the first 48 hours regarding minimum pain severity (P=.005 and .01 for 24 and 48 hours, respectively) and for the first 72 hours for maximum pain severity (P=.014, .007, and .001 for 24, 48, and 72 hours, respectively). No significant differences were observed for side effects, symptoms, or healing time except discomfort in favor of gabapentin during the first 24 hours (P=.043).

CONCLUSIONS

Gabapentin significantly reduced postoperative pain after PRK compared to placebo, with no increase in reported side effects.

Authors+Show Affiliations

Codet Vision Institute, Tijuana, Mexico. drlichtinger@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21366172

Citation

Lichtinger, Alejandro, et al. "Gabapentin for Postoperative Pain After Photorefractive Keratectomy: a Prospective, Randomized, Double-blind, Placebo-controlled Trial." Journal of Refractive Surgery (Thorofare, N.J. : 1995), vol. 27, no. 8, 2011, pp. 613-7.
Lichtinger A, Purcell TL, Schanzlin DJ, et al. Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial. J Refract Surg. 2011;27(8):613-7.
Lichtinger, A., Purcell, T. L., Schanzlin, D. J., & Chayet, A. S. (2011). Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial. Journal of Refractive Surgery (Thorofare, N.J. : 1995), 27(8), 613-7. https://doi.org/10.3928/1081597X-20110210-01
Lichtinger A, et al. Gabapentin for Postoperative Pain After Photorefractive Keratectomy: a Prospective, Randomized, Double-blind, Placebo-controlled Trial. J Refract Surg. 2011;27(8):613-7. PubMed PMID: 21366172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial. AU - Lichtinger,Alejandro, AU - Purcell,Tracy L, AU - Schanzlin,David J, AU - Chayet,Arturo S, Y1 - 2011/02/28/ PY - 2010/12/01/received PY - 2011/02/01/accepted PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2011/12/13/medline SP - 613 EP - 7 JF - Journal of refractive surgery (Thorofare, N.J. : 1995) JO - J Refract Surg VL - 27 IS - 8 N2 - PURPOSE: To determine whether treatment with oral gabapentin reduces postoperative pain after photorefractive keratectomy (PRK). METHODS: This prospective, randomized, double-blind, placebo-controlled study comprised 40 patients scheduled for bilateral PRK. Exclusion criteria were previous refractive surgery; diseases that could affect epithelial healing; use of antihistamines, nonsteroidal anti-inflammatory drugs, or steroids; and use of mitomycin C during PRK. Patients were divided into two groups: 20 patients received gabapentin capsules (300 mg) and 20 patients received identical placebo capsules. Visual acuity, slit-lamp examination, and a 12-question, 10-point visual numerical scale questionnaire were evaluated at each postoperative follow-up. Main outcome measures were the severity of pain at each follow-up and during the previous 24 hours. Secondary outcome measures were maximum and minimum severity of pain, healing time, uncorrected distance visual acuity, and the rating of other symptoms and potential side effects. RESULTS: The gabapentin group had less pain during the first 72 hours (P=.024 to .001). A significant difference in favor of gabapentin was found for the first 48 hours regarding minimum pain severity (P=.005 and .01 for 24 and 48 hours, respectively) and for the first 72 hours for maximum pain severity (P=.014, .007, and .001 for 24, 48, and 72 hours, respectively). No significant differences were observed for side effects, symptoms, or healing time except discomfort in favor of gabapentin during the first 24 hours (P=.043). CONCLUSIONS: Gabapentin significantly reduced postoperative pain after PRK compared to placebo, with no increase in reported side effects. SN - 1081-597X UR - https://www.unboundmedicine.com/medline/citation/21366172/Gabapentin_for_postoperative_pain_after_photorefractive_keratectomy:_a_prospective_randomized_double_blind_placebo_controlled_trial_ L2 - https://www.healio.com/doiresolver?doi=10.3928/1081597X-20110210-01 DB - PRIME DP - Unbound Medicine ER -