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Human coronavirus NL63: a clinically important virus?
Future Microbiol. 2011 Feb; 6(2):153-9.FM

Abstract

Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract infections. To date, five coronaviruses (HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63 and HCoV HKU-1) that infect humans have been identified, four of which (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU-1) circulate continuously in the human population. Human coronavirus NL63 (HCoV-NL63) was first isolated from the aspirate from a 7-month-old baby in early 2004. Infection with HCoV-NL63 has since been shown to be a common worldwide occurrence and has been associated with many clinical symptoms and diagnoses, including severe lower respiratory tract infection, croup and bronchiolitis. HCoV-NL63 causes disease in children, the elderly and the immunocompromised, and has been detected in 1.0-9.3% of respiratory tract infections in children. In this article, the current knowledge of human coronavirus HCoV-NL63, with special reference to the clinical features, prevalence and seasonal incidence, and coinfection with other respiratory viruses, will be discussed.

Authors+Show Affiliations

Molecular Virology Research Laboratory, Medical Microbiology Cluster, Department of Medical Biosciences, Faculty of Natural Sciences, University of the Western Cape, Private Bag X17, Modderdam Road, Bellville, Western Cape, 7535, South Africa. bfielding@uwc.ac.za

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21366416

Citation

Fielding, Burtram C.. "Human Coronavirus NL63: a Clinically Important Virus?" Future Microbiology, vol. 6, no. 2, 2011, pp. 153-9.
Fielding BC. Human coronavirus NL63: a clinically important virus? Future Microbiol. 2011;6(2):153-9.
Fielding, B. C. (2011). Human coronavirus NL63: a clinically important virus? Future Microbiology, 6(2), 153-9. https://doi.org/10.2217/fmb.10.166
Fielding BC. Human Coronavirus NL63: a Clinically Important Virus. Future Microbiol. 2011;6(2):153-9. PubMed PMID: 21366416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human coronavirus NL63: a clinically important virus? A1 - Fielding,Burtram C, PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2011/6/8/medline SP - 153 EP - 9 JF - Future microbiology JO - Future Microbiol VL - 6 IS - 2 N2 - Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract infections. To date, five coronaviruses (HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63 and HCoV HKU-1) that infect humans have been identified, four of which (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU-1) circulate continuously in the human population. Human coronavirus NL63 (HCoV-NL63) was first isolated from the aspirate from a 7-month-old baby in early 2004. Infection with HCoV-NL63 has since been shown to be a common worldwide occurrence and has been associated with many clinical symptoms and diagnoses, including severe lower respiratory tract infection, croup and bronchiolitis. HCoV-NL63 causes disease in children, the elderly and the immunocompromised, and has been detected in 1.0-9.3% of respiratory tract infections in children. In this article, the current knowledge of human coronavirus HCoV-NL63, with special reference to the clinical features, prevalence and seasonal incidence, and coinfection with other respiratory viruses, will be discussed. SN - 1746-0921 UR - https://www.unboundmedicine.com/medline/citation/21366416/Human_coronavirus_NL63:_a_clinically_important_virus L2 - https://www.futuremedicine.com/doi/10.2217/fmb.10.166?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -