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Current alcohol consumption and its relationship to incident dementia: results from a 3-year follow-up study among primary care attenders aged 75 years and older.
Age Ageing. 2011 Jul; 40(4):456-63.AA

Abstract

OBJECTIVE

to investigate prospectively the relationship between current alcohol consumption (quantity and type of alcohol) and incident overall dementia and Alzheimer dementia.

METHOD

the study is based on individuals (75+) attending general practitioners in Germany: 3,202 subjects free of dementia were studied at baseline, 1.5 years and 3 years later by means of structured clinical interviews including detailed assessment of current alcohol consumption and DSM-IV dementia diagnoses. Associations between alcohol consumption (in grams of ethanol), type of alcohol (wine, beer, mixed alcohol beverages) and incident dementia were examined using Cox proportional hazard models, controlling for several confounders.

RESULTS

incident overall dementia occurred in 217 of 3,202 participants over a mean follow-up period of 3 years. Significant relationships were found between alcohol consumption (prevalence at baseline: 50.0%) and incident overall dementia (adjusted hazard ratio (HR) 0.71, 95% CI 0.53-0.96), respectively, incident Alzheimer dementia (adjusted HR 0.58, 95% CI 0.38-0.89). With regard to quantity of alcohol and type of alcohol, all hazard ratios were found to be lower than 1.

CONCLUSION

in agreement with meta-analyses that include younger age groups, our study suggests that light-to-moderate alcohol consumption is inversely related to incident dementia, also among individuals aged 75 years and older.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Weyerer S
Central Institute of Mental Health, Mannheim, Germany. siegfried.weyerer@zi-mannheim.de
Schäufele M
No affiliation info available
Wiese B
No affiliation info available
Maier W
No affiliation info available
Tebarth F
No affiliation info available
van den Bussche H
No affiliation info available
Pentzek M
No affiliation info available
Bickel H
No affiliation info available
Luppa M
No affiliation info available
Riedel-Heller SG
No affiliation info available
German AgeCoDe Study group (German Study on Ageing, Cognition and Dementia in Primary Care Patients)
No affiliation info available

MeSH

Age FactorsAgedAged, 80 and overAgingAlcohol DrinkingAlzheimer DiseaseDementiaFemaleFollow-Up StudiesGermanyHumansIncidenceMalePrimary Health CareProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21367764

Citation

Weyerer, Siegfried, et al. "Current Alcohol Consumption and Its Relationship to Incident Dementia: Results From a 3-year Follow-up Study Among Primary Care Attenders Aged 75 Years and Older." Age and Ageing, vol. 40, no. 4, 2011, pp. 456-63.
Weyerer S, Schäufele M, Wiese B, et al. Current alcohol consumption and its relationship to incident dementia: results from a 3-year follow-up study among primary care attenders aged 75 years and older. Age Ageing. 2011;40(4):456-63.
Weyerer, S., Schäufele, M., Wiese, B., Maier, W., Tebarth, F., van den Bussche, H., Pentzek, M., Bickel, H., Luppa, M., & Riedel-Heller, S. G. (2011). Current alcohol consumption and its relationship to incident dementia: results from a 3-year follow-up study among primary care attenders aged 75 years and older. Age and Ageing, 40(4), 456-63. https://doi.org/10.1093/ageing/afr007
Weyerer S, et al. Current Alcohol Consumption and Its Relationship to Incident Dementia: Results From a 3-year Follow-up Study Among Primary Care Attenders Aged 75 Years and Older. Age Ageing. 2011;40(4):456-63. PubMed PMID: 21367764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current alcohol consumption and its relationship to incident dementia: results from a 3-year follow-up study among primary care attenders aged 75 years and older. AU - Weyerer,Siegfried, AU - Schäufele,Martina, AU - Wiese,Birgitt, AU - Maier,Wolfgang, AU - Tebarth,Franziska, AU - van den Bussche,Hendrik, AU - Pentzek,Michael, AU - Bickel,Horst, AU - Luppa,Melanie, AU - Riedel-Heller,Steffi G, AU - ,, Y1 - 2011/03/02/ PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2011/10/8/medline SP - 456 EP - 63 JF - Age and ageing JO - Age Ageing VL - 40 IS - 4 N2 - OBJECTIVE: to investigate prospectively the relationship between current alcohol consumption (quantity and type of alcohol) and incident overall dementia and Alzheimer dementia. METHOD: the study is based on individuals (75+) attending general practitioners in Germany: 3,202 subjects free of dementia were studied at baseline, 1.5 years and 3 years later by means of structured clinical interviews including detailed assessment of current alcohol consumption and DSM-IV dementia diagnoses. Associations between alcohol consumption (in grams of ethanol), type of alcohol (wine, beer, mixed alcohol beverages) and incident dementia were examined using Cox proportional hazard models, controlling for several confounders. RESULTS: incident overall dementia occurred in 217 of 3,202 participants over a mean follow-up period of 3 years. Significant relationships were found between alcohol consumption (prevalence at baseline: 50.0%) and incident overall dementia (adjusted hazard ratio (HR) 0.71, 95% CI 0.53-0.96), respectively, incident Alzheimer dementia (adjusted HR 0.58, 95% CI 0.38-0.89). With regard to quantity of alcohol and type of alcohol, all hazard ratios were found to be lower than 1. CONCLUSION: in agreement with meta-analyses that include younger age groups, our study suggests that light-to-moderate alcohol consumption is inversely related to incident dementia, also among individuals aged 75 years and older. SN - 1468-2834 UR - https://www.unboundmedicine.com/medline/citation/21367764/Current_alcohol_consumption_and_its_relationship_to_incident_dementia:_results_from_a_3_year_follow_up_study_among_primary_care_attenders_aged_75_years_and_older_ DB - PRIME DP - Unbound Medicine ER -