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Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study.
Am J Clin Nutr 2011; 93(5):1142-51AJ

Abstract

BACKGROUND

Polyunsaturated fatty acids and fish may influence bone health.

OBJECTIVE

We aimed to examine associations between dietary polyunsaturated fatty acid and fish intakes and hip bone mineral density (BMD) at baseline (1988-1989; n = 854) and changes 4 y later in adults (n = 623) with a mean age of 75 y in the Framingham Osteoporosis Study.

DESIGN

BMD measures were regressed on energy-adjusted quartiles of fatty acid intakes [n-3 (omega-3): α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA+ DHA; n-6 (omega-6): linoleic acid (LA) and arachidonic acid (AA); and n-6:n-3 ratio] and on categorized fish intakes, with adjustment for covariates. Effect modification by EPA+DHA intake was tested for n-6 exposures.

RESULTS

High intakes (≥3 servings/wk) of fish relative to lower intakes were associated with maintenance of femoral neck BMD (FN-BMD) in men (dark fish + tuna, dark fish, and tuna) and in women (dark fish) (P < 0.05). Significant interactions between AA and EPA+DHA intakes were observed cross-sectionally in women and longitudinally in men. In women with EPA+DHA intakes at or above the median, those with the highest AA intakes had a higher mean baseline FN-BMD than did those with the lowest intakes (quartile 4 compared with quartile 1: P = 0.03, P for trend = 0.02). In men with the lowest EPA+DHA intakes (quartile 1), those with the highest intakes of AA (quartile 4) lost more FN-BMD than did men with the lowest intakes of AA (quartile 1; P = 0.04). LA intake tended to be associated with FN-BMD loss in women (P for trend < 0.06).

CONCLUSIONS

Fish consumption may protect against bone loss. The protective effects of a high AA intake may be dependent on the amount of EPA+DHA intake.

Authors+Show Affiliations

Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21367955

Citation

Farina, Emily K., et al. "Protective Effects of Fish Intake and Interactive Effects of Long-chain Polyunsaturated Fatty Acid Intakes On Hip Bone Mineral Density in Older Adults: the Framingham Osteoporosis Study." The American Journal of Clinical Nutrition, vol. 93, no. 5, 2011, pp. 1142-51.
Farina EK, Kiel DP, Roubenoff R, et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93(5):1142-51.
Farina, E. K., Kiel, D. P., Roubenoff, R., Schaefer, E. J., Cupples, L. A., & Tucker, K. L. (2011). Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. The American Journal of Clinical Nutrition, 93(5), pp. 1142-51. doi:10.3945/ajcn.110.005926.
Farina EK, et al. Protective Effects of Fish Intake and Interactive Effects of Long-chain Polyunsaturated Fatty Acid Intakes On Hip Bone Mineral Density in Older Adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93(5):1142-51. PubMed PMID: 21367955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. AU - Farina,Emily K, AU - Kiel,Douglas P, AU - Roubenoff,Ronenn, AU - Schaefer,Ernst J, AU - Cupples,L Adrienne, AU - Tucker,Katherine L, Y1 - 2011/03/02/ PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2011/7/16/medline SP - 1142 EP - 51 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 93 IS - 5 N2 - BACKGROUND: Polyunsaturated fatty acids and fish may influence bone health. OBJECTIVE: We aimed to examine associations between dietary polyunsaturated fatty acid and fish intakes and hip bone mineral density (BMD) at baseline (1988-1989; n = 854) and changes 4 y later in adults (n = 623) with a mean age of 75 y in the Framingham Osteoporosis Study. DESIGN: BMD measures were regressed on energy-adjusted quartiles of fatty acid intakes [n-3 (omega-3): α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA+ DHA; n-6 (omega-6): linoleic acid (LA) and arachidonic acid (AA); and n-6:n-3 ratio] and on categorized fish intakes, with adjustment for covariates. Effect modification by EPA+DHA intake was tested for n-6 exposures. RESULTS: High intakes (≥3 servings/wk) of fish relative to lower intakes were associated with maintenance of femoral neck BMD (FN-BMD) in men (dark fish + tuna, dark fish, and tuna) and in women (dark fish) (P < 0.05). Significant interactions between AA and EPA+DHA intakes were observed cross-sectionally in women and longitudinally in men. In women with EPA+DHA intakes at or above the median, those with the highest AA intakes had a higher mean baseline FN-BMD than did those with the lowest intakes (quartile 4 compared with quartile 1: P = 0.03, P for trend = 0.02). In men with the lowest EPA+DHA intakes (quartile 1), those with the highest intakes of AA (quartile 4) lost more FN-BMD than did men with the lowest intakes of AA (quartile 1; P = 0.04). LA intake tended to be associated with FN-BMD loss in women (P for trend < 0.06). CONCLUSIONS: Fish consumption may protect against bone loss. The protective effects of a high AA intake may be dependent on the amount of EPA+DHA intake. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21367955/Protective_effects_of_fish_intake_and_interactive_effects_of_long_chain_polyunsaturated_fatty_acid_intakes_on_hip_bone_mineral_density_in_older_adults:_the_Framingham_Osteoporosis_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.110.005926 DB - PRIME DP - Unbound Medicine ER -