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Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study.

Abstract

BACKGROUND

Polyunsaturated fatty acids and fish may influence bone health.

OBJECTIVE

We aimed to examine associations between dietary polyunsaturated fatty acid and fish intakes and hip bone mineral density (BMD) at baseline (1988-1989; n = 854) and changes 4 y later in adults (n = 623) with a mean age of 75 y in the Framingham Osteoporosis Study.

DESIGN

BMD measures were regressed on energy-adjusted quartiles of fatty acid intakes [n-3 (omega-3): α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA+ DHA; n-6 (omega-6): linoleic acid (LA) and arachidonic acid (AA); and n-6:n-3 ratio] and on categorized fish intakes, with adjustment for covariates. Effect modification by EPA+DHA intake was tested for n-6 exposures.

RESULTS

High intakes (≥3 servings/wk) of fish relative to lower intakes were associated with maintenance of femoral neck BMD (FN-BMD) in men (dark fish + tuna, dark fish, and tuna) and in women (dark fish) (P < 0.05). Significant interactions between AA and EPA+DHA intakes were observed cross-sectionally in women and longitudinally in men. In women with EPA+DHA intakes at or above the median, those with the highest AA intakes had a higher mean baseline FN-BMD than did those with the lowest intakes (quartile 4 compared with quartile 1: P = 0.03, P for trend = 0.02). In men with the lowest EPA+DHA intakes (quartile 1), those with the highest intakes of AA (quartile 4) lost more FN-BMD than did men with the lowest intakes of AA (quartile 1; P = 0.04). LA intake tended to be associated with FN-BMD loss in women (P for trend < 0.06).

CONCLUSIONS

Fish consumption may protect against bone loss. The protective effects of a high AA intake may be dependent on the amount of EPA+DHA intake.

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    ,

    Friedman School of Nutrition Science and Policy, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02115, USA.

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    Source

    MeSH

    Aged
    Aged, 80 and over
    Animals
    Arachidonic Acid
    Bone Density
    Bone Resorption
    Cross-Sectional Studies
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Unsaturated
    Female
    Femur Neck
    Fishes
    Hip
    Humans
    Longitudinal Studies
    Male
    Osteoporosis
    Seafood
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21367955

    Citation

    Farina, Emily K., et al. "Protective Effects of Fish Intake and Interactive Effects of Long-chain Polyunsaturated Fatty Acid Intakes On Hip Bone Mineral Density in Older Adults: the Framingham Osteoporosis Study." The American Journal of Clinical Nutrition, vol. 93, no. 5, 2011, pp. 1142-51.
    Farina EK, Kiel DP, Roubenoff R, et al. Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93(5):1142-51.
    Farina, E. K., Kiel, D. P., Roubenoff, R., Schaefer, E. J., Cupples, L. A., & Tucker, K. L. (2011). Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. The American Journal of Clinical Nutrition, 93(5), pp. 1142-51. doi:10.3945/ajcn.110.005926.
    Farina EK, et al. Protective Effects of Fish Intake and Interactive Effects of Long-chain Polyunsaturated Fatty Acid Intakes On Hip Bone Mineral Density in Older Adults: the Framingham Osteoporosis Study. Am J Clin Nutr. 2011;93(5):1142-51. PubMed PMID: 21367955.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Protective effects of fish intake and interactive effects of long-chain polyunsaturated fatty acid intakes on hip bone mineral density in older adults: the Framingham Osteoporosis Study. AU - Farina,Emily K, AU - Kiel,Douglas P, AU - Roubenoff,Ronenn, AU - Schaefer,Ernst J, AU - Cupples,L Adrienne, AU - Tucker,Katherine L, Y1 - 2011/03/02/ PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2011/7/16/medline SP - 1142 EP - 51 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 93 IS - 5 N2 - BACKGROUND: Polyunsaturated fatty acids and fish may influence bone health. OBJECTIVE: We aimed to examine associations between dietary polyunsaturated fatty acid and fish intakes and hip bone mineral density (BMD) at baseline (1988-1989; n = 854) and changes 4 y later in adults (n = 623) with a mean age of 75 y in the Framingham Osteoporosis Study. DESIGN: BMD measures were regressed on energy-adjusted quartiles of fatty acid intakes [n-3 (omega-3): α-linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and EPA+ DHA; n-6 (omega-6): linoleic acid (LA) and arachidonic acid (AA); and n-6:n-3 ratio] and on categorized fish intakes, with adjustment for covariates. Effect modification by EPA+DHA intake was tested for n-6 exposures. RESULTS: High intakes (≥3 servings/wk) of fish relative to lower intakes were associated with maintenance of femoral neck BMD (FN-BMD) in men (dark fish + tuna, dark fish, and tuna) and in women (dark fish) (P < 0.05). Significant interactions between AA and EPA+DHA intakes were observed cross-sectionally in women and longitudinally in men. In women with EPA+DHA intakes at or above the median, those with the highest AA intakes had a higher mean baseline FN-BMD than did those with the lowest intakes (quartile 4 compared with quartile 1: P = 0.03, P for trend = 0.02). In men with the lowest EPA+DHA intakes (quartile 1), those with the highest intakes of AA (quartile 4) lost more FN-BMD than did men with the lowest intakes of AA (quartile 1; P = 0.04). LA intake tended to be associated with FN-BMD loss in women (P for trend < 0.06). CONCLUSIONS: Fish consumption may protect against bone loss. The protective effects of a high AA intake may be dependent on the amount of EPA+DHA intake. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21367955/Protective_effects_of_fish_intake_and_interactive_effects_of_long_chain_polyunsaturated_fatty_acid_intakes_on_hip_bone_mineral_density_in_older_adults:_the_Framingham_Osteoporosis_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.110.005926 DB - PRIME DP - Unbound Medicine ER -