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The composition and extent of coronary artery plaque detected by multislice computed tomographic angiography provides incremental prognostic value in patients with suspected coronary artery disease.
Int J Cardiovasc Imaging. 2012 Mar; 28(3):621-31.IJ

Abstract

Multislice computed tomographic coronary angiography (CTCA) provides accurate noninvasive assessment of coronary artery disease (CAD). However, data on the prognostic value of CTCA in patients with suspected CAD are only beginning to emerge. The aim of the study was to assess the prognostic value of CTCA in patients with suspected CAD. Patients (males = 259, females = 235; mean age 58.2 ± 9.8 years) with suspected CAD who underwent 16- or 64-slice CTCA were followed for 1,308 ± 318 days for cardiac death, nonfatal myocaridal infarction (MI) and late (>90 days after CTCA) revascularization. Patient outcomes were related to clinical and CTCA data. Cox proportional-hazards model was applied in stepwise forward fashion to identify outcome predictors. Coronary artery plaque was found in 340 patients. Cardiac events occurred in 40 patients including cardiac death (n = 9), nonfatal MI (n = 8) and late revascularization (n = 23). A multivariable analysis identified the following independent predictors for adverse cardiac events: obstructive plaque in a proximal coronary artery segment (hazard ratio (HR) 2.73; 95% confidence interval (CI): 1.35-5.54; P = 0.005), the number of segments with noncalcified plaque(s) (HR 1.53 per segment; 95%CI: 1.21-1.92; P < 0.001), the number of segments with mixed plaque(s) (HR 1.56 per segment; 95%CI: 1.27-1.92; P < 0.001) and the number of segments with calcified plaque(s) (HR 1.21 per segment; 95%CI: 1.07-1.37; P = 0.002). In patients with suspected CAD, both the extent and composition of atherosclerotic plaque as determined by CTCA are prognostic of subsequent cardiac events.

Authors+Show Affiliations

Center for Diagnosis, Prevention and Telemedicine, John Paul II Hospital, ul. Prądnicka 80, 31-202 Kraków, Poland. miszalt@mp.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21369735

Citation

Miszalski-Jamka, Tomasz, et al. "The Composition and Extent of Coronary Artery Plaque Detected By Multislice Computed Tomographic Angiography Provides Incremental Prognostic Value in Patients With Suspected Coronary Artery Disease." The International Journal of Cardiovascular Imaging, vol. 28, no. 3, 2012, pp. 621-31.
Miszalski-Jamka T, Klimeczek P, Banyś R, et al. The composition and extent of coronary artery plaque detected by multislice computed tomographic angiography provides incremental prognostic value in patients with suspected coronary artery disease. Int J Cardiovasc Imaging. 2012;28(3):621-31.
Miszalski-Jamka, T., Klimeczek, P., Banyś, R., Krupiński, M., Nycz, K., Bury, K., Lada, M., Pelberg, R., Kereiakes, D., & Mazur, W. (2012). The composition and extent of coronary artery plaque detected by multislice computed tomographic angiography provides incremental prognostic value in patients with suspected coronary artery disease. The International Journal of Cardiovascular Imaging, 28(3), 621-31. https://doi.org/10.1007/s10554-011-9799-0
Miszalski-Jamka T, et al. The Composition and Extent of Coronary Artery Plaque Detected By Multislice Computed Tomographic Angiography Provides Incremental Prognostic Value in Patients With Suspected Coronary Artery Disease. Int J Cardiovasc Imaging. 2012;28(3):621-31. PubMed PMID: 21369735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The composition and extent of coronary artery plaque detected by multislice computed tomographic angiography provides incremental prognostic value in patients with suspected coronary artery disease. AU - Miszalski-Jamka,Tomasz, AU - Klimeczek,Piotr, AU - Banyś,Robert, AU - Krupiński,Maciej, AU - Nycz,Krzysztof, AU - Bury,Krzysztof, AU - Lada,Michał, AU - Pelberg,Robert, AU - Kereiakes,Dean, AU - Mazur,Wojciech, Y1 - 2011/03/03/ PY - 2010/08/01/received PY - 2011/01/08/accepted PY - 2011/3/4/entrez PY - 2011/3/4/pubmed PY - 2012/9/7/medline SP - 621 EP - 31 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 28 IS - 3 N2 - Multislice computed tomographic coronary angiography (CTCA) provides accurate noninvasive assessment of coronary artery disease (CAD). However, data on the prognostic value of CTCA in patients with suspected CAD are only beginning to emerge. The aim of the study was to assess the prognostic value of CTCA in patients with suspected CAD. Patients (males = 259, females = 235; mean age 58.2 ± 9.8 years) with suspected CAD who underwent 16- or 64-slice CTCA were followed for 1,308 ± 318 days for cardiac death, nonfatal myocaridal infarction (MI) and late (>90 days after CTCA) revascularization. Patient outcomes were related to clinical and CTCA data. Cox proportional-hazards model was applied in stepwise forward fashion to identify outcome predictors. Coronary artery plaque was found in 340 patients. Cardiac events occurred in 40 patients including cardiac death (n = 9), nonfatal MI (n = 8) and late revascularization (n = 23). A multivariable analysis identified the following independent predictors for adverse cardiac events: obstructive plaque in a proximal coronary artery segment (hazard ratio (HR) 2.73; 95% confidence interval (CI): 1.35-5.54; P = 0.005), the number of segments with noncalcified plaque(s) (HR 1.53 per segment; 95%CI: 1.21-1.92; P < 0.001), the number of segments with mixed plaque(s) (HR 1.56 per segment; 95%CI: 1.27-1.92; P < 0.001) and the number of segments with calcified plaque(s) (HR 1.21 per segment; 95%CI: 1.07-1.37; P = 0.002). In patients with suspected CAD, both the extent and composition of atherosclerotic plaque as determined by CTCA are prognostic of subsequent cardiac events. SN - 1875-8312 UR - https://www.unboundmedicine.com/medline/citation/21369735/The_composition_and_extent_of_coronary_artery_plaque_detected_by_multislice_computed_tomographic_angiography_provides_incremental_prognostic_value_in_patients_with_suspected_coronary_artery_disease_ L2 - https://doi.org/10.1007/s10554-011-9799-0 DB - PRIME DP - Unbound Medicine ER -