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The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS.
BJU Int. 2011 Nov; 108(9):1459-71.BI

Abstract

OBJECTIVE

• To examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively.

PATIENTS AND METHODS

• A cross-sectional population-representative survey was conducted via the Internet in the UK, Sweden and USA. • Participants rated the frequency and bother of OAB and LUTS. Patient outcomes included the Overactive Bladder Questionnaire Short Form, Patient Perception of Bladder Condition, Short Form-12, Hospital Anxiety and Depression Scale-Anxiety and Hospital Anxiety and Depression Scale-Depression, as well as questions about treatment seeking and work productivity. • OAB was defined as urgency at least sometimes or the presence of urinary urgency incontinence. Three subgroups were compared: no/minimal symptoms, OAB without bother and OAB with bother. • Analyses were conducted by gender and country using general linear and logistic regression models to examine bothersome OAB and treatment seeking.

RESULTS

• Survey response was 59.2%; 10,000 people (4724 men and 5276 women) participated. • The prevalence of OAB with bother at least 'somewhat' was 10.9% and 14.6% for men in the UK and Sweden, and 22.5% and 33.7% for women in the UK and Sweden, respectively. • Men and women with bothersome OAB were significantly more likely to seek treatment, report the lowest levels of health-related quality of life and work productivity and the highest levels of anxiety and depression compared to those with no/minimal symptoms and OAB without bother. • Greater symptom severity of urgency, urgency urinary incontinence, frequency, nocturia, and increasing levels of anxiety were strongly predictive of OAB bother in both men and women. • Predictors of treatment seeking included frequency, bother as a result of urgency, and lower levels of depressive symptoms in men, and frequency, nocturia and urgency in women.

CONCLUSIONS

• OAB is common in the UK and Sweden, and women are more likely to be affected then men. • The impact of OAB is evident across generic and condition-specific domains of health-related quality of life.

Authors+Show Affiliations

United BioSource Corporation, Bethesda, MD, USA. karin.coyne@unitedbiosource.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21371240

Citation

Coyne, Karin S., et al. "The Impact of Overactive Bladder On Mental Health, Work Productivity and Health-related Quality of Life in the UK and Sweden: Results From EpiLUTS." BJU International, vol. 108, no. 9, 2011, pp. 1459-71.
Coyne KS, Sexton CC, Kopp ZS, et al. The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS. BJU Int. 2011;108(9):1459-71.
Coyne, K. S., Sexton, C. C., Kopp, Z. S., Ebel-Bitoun, C., Milsom, I., & Chapple, C. (2011). The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS. BJU International, 108(9), 1459-71. https://doi.org/10.1111/j.1464-410X.2010.10013.x
Coyne KS, et al. The Impact of Overactive Bladder On Mental Health, Work Productivity and Health-related Quality of Life in the UK and Sweden: Results From EpiLUTS. BJU Int. 2011;108(9):1459-71. PubMed PMID: 21371240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of overactive bladder on mental health, work productivity and health-related quality of life in the UK and Sweden: results from EpiLUTS. AU - Coyne,Karin S, AU - Sexton,Chris C, AU - Kopp,Zoe S, AU - Ebel-Bitoun,Caty, AU - Milsom,Ian, AU - Chapple,Chris, Y1 - 2011/03/03/ PY - 2011/3/5/entrez PY - 2011/3/5/pubmed PY - 2011/12/29/medline SP - 1459 EP - 71 JF - BJU international JO - BJU Int VL - 108 IS - 9 N2 - OBJECTIVE: • To examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively. PATIENTS AND METHODS: • A cross-sectional population-representative survey was conducted via the Internet in the UK, Sweden and USA. • Participants rated the frequency and bother of OAB and LUTS. Patient outcomes included the Overactive Bladder Questionnaire Short Form, Patient Perception of Bladder Condition, Short Form-12, Hospital Anxiety and Depression Scale-Anxiety and Hospital Anxiety and Depression Scale-Depression, as well as questions about treatment seeking and work productivity. • OAB was defined as urgency at least sometimes or the presence of urinary urgency incontinence. Three subgroups were compared: no/minimal symptoms, OAB without bother and OAB with bother. • Analyses were conducted by gender and country using general linear and logistic regression models to examine bothersome OAB and treatment seeking. RESULTS: • Survey response was 59.2%; 10,000 people (4724 men and 5276 women) participated. • The prevalence of OAB with bother at least 'somewhat' was 10.9% and 14.6% for men in the UK and Sweden, and 22.5% and 33.7% for women in the UK and Sweden, respectively. • Men and women with bothersome OAB were significantly more likely to seek treatment, report the lowest levels of health-related quality of life and work productivity and the highest levels of anxiety and depression compared to those with no/minimal symptoms and OAB without bother. • Greater symptom severity of urgency, urgency urinary incontinence, frequency, nocturia, and increasing levels of anxiety were strongly predictive of OAB bother in both men and women. • Predictors of treatment seeking included frequency, bother as a result of urgency, and lower levels of depressive symptoms in men, and frequency, nocturia and urgency in women. CONCLUSIONS: • OAB is common in the UK and Sweden, and women are more likely to be affected then men. • The impact of OAB is evident across generic and condition-specific domains of health-related quality of life. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/21371240/The_impact_of_overactive_bladder_on_mental_health_work_productivity_and_health_related_quality_of_life_in_the_UK_and_Sweden:_results_from_EpiLUTS_ L2 - https://doi.org/10.1111/j.1464-410X.2010.10013.x DB - PRIME DP - Unbound Medicine ER -