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Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems.
Eur J Pharmacol. 2011 May 11; 658(2-3):145-9.EJ

Abstract

Serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. The organoselenium compound m-trifluoromethyl-diphenyl diselenide (m-CF(3)-PhSe)(2) shows antioxidant and anxiolytic activities and is a selective inhibitor of monoamine oxidase A activity. The present study was designed to investigate the antidepressant-like effect of (m-CF(3)-PhSe)(2) in female mice, employing the forced swimming test. The involvement of the serotonergic and opioid systems in the antidepressant-like effect of (m-CF(3)-PhSe)(2) was appraised. (m-CF(3)-PhSe)(2) at doses of 50 and 100mg/kg (p.o.) exhibited antidepressant-like action in the forced swimming test. The effect of (m-CF(3)-PhSe)(2) (50mg/kg p.o.) was prevented by pretreatment of mice with WAY100635 (0.1mg/kg, s.c. a selective 5-HT(1A) receptor antagonist), ritanserin (4 mg/kg, i.p., a non-selective 5HT(2A/2C) receptor antagonist), ondansetron (1mg/kg, i.p., a selective 5-HT(3) receptor antagonist) and naloxone (1mg/kg, i.p., a non-selective antagonist of opioid receptors). These results suggest that (m-CF(3)-PhSe)(2) produced an antidepressant-like effect in the mouse forced swimming test and this effect seems most likely to be mediated through an interaction with serotonergic and opioid systems.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21371464

Citation

Brüning, César Augusto, et al. "Antidepressant-like Effect of M-trifluoromethyl-diphenyl Diselenide in the Mouse Forced Swimming Test Involves Opioid and Serotonergic Systems." European Journal of Pharmacology, vol. 658, no. 2-3, 2011, pp. 145-9.
Brüning CA, Souza AC, Gai BM, et al. Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems. Eur J Pharmacol. 2011;658(2-3):145-9.
Brüning, C. A., Souza, A. C., Gai, B. M., Zeni, G., & Nogueira, C. W. (2011). Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems. European Journal of Pharmacology, 658(2-3), 145-9. https://doi.org/10.1016/j.ejphar.2011.02.039
Brüning CA, et al. Antidepressant-like Effect of M-trifluoromethyl-diphenyl Diselenide in the Mouse Forced Swimming Test Involves Opioid and Serotonergic Systems. Eur J Pharmacol. 2011 May 11;658(2-3):145-9. PubMed PMID: 21371464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems. AU - Brüning,César Augusto, AU - Souza,Ana Cristina Guerra, AU - Gai,Bibiana Mozzaquatro, AU - Zeni,Gilson, AU - Nogueira,Cristina Wayne, Y1 - 2011/03/01/ PY - 2010/10/28/received PY - 2011/02/01/revised PY - 2011/02/17/accepted PY - 2011/3/5/entrez PY - 2011/3/5/pubmed PY - 2011/7/26/medline SP - 145 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 658 IS - 2-3 N2 - Serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. The organoselenium compound m-trifluoromethyl-diphenyl diselenide (m-CF(3)-PhSe)(2) shows antioxidant and anxiolytic activities and is a selective inhibitor of monoamine oxidase A activity. The present study was designed to investigate the antidepressant-like effect of (m-CF(3)-PhSe)(2) in female mice, employing the forced swimming test. The involvement of the serotonergic and opioid systems in the antidepressant-like effect of (m-CF(3)-PhSe)(2) was appraised. (m-CF(3)-PhSe)(2) at doses of 50 and 100mg/kg (p.o.) exhibited antidepressant-like action in the forced swimming test. The effect of (m-CF(3)-PhSe)(2) (50mg/kg p.o.) was prevented by pretreatment of mice with WAY100635 (0.1mg/kg, s.c. a selective 5-HT(1A) receptor antagonist), ritanserin (4 mg/kg, i.p., a non-selective 5HT(2A/2C) receptor antagonist), ondansetron (1mg/kg, i.p., a selective 5-HT(3) receptor antagonist) and naloxone (1mg/kg, i.p., a non-selective antagonist of opioid receptors). These results suggest that (m-CF(3)-PhSe)(2) produced an antidepressant-like effect in the mouse forced swimming test and this effect seems most likely to be mediated through an interaction with serotonergic and opioid systems. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21371464/Antidepressant_like_effect_of_m_trifluoromethyl_diphenyl_diselenide_in_the_mouse_forced_swimming_test_involves_opioid_and_serotonergic_systems_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00224-X DB - PRIME DP - Unbound Medicine ER -