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Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.
Eur J Pharmacol. 2011 May 11; 658(2-3):263-9.EJ

Abstract

Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-α and interferon (IFN)-γ) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis.

Authors+Show Affiliations

Department of Dermatology, General Hospital of the Air Force, Beijing 1000142, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21371468

Citation

Yuan, Xiao-Ying, et al. "Topical Application of Aloperine Improves 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice." European Journal of Pharmacology, vol. 658, no. 2-3, 2011, pp. 263-9.
Yuan XY, Ma HM, Li RZ, et al. Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. Eur J Pharmacol. 2011;658(2-3):263-9.
Yuan, X. Y., Ma, H. M., Li, R. Z., Wang, R. Y., Liu, W., & Guo, J. Y. (2011). Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. European Journal of Pharmacology, 658(2-3), 263-9. https://doi.org/10.1016/j.ejphar.2011.02.013
Yuan XY, et al. Topical Application of Aloperine Improves 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice. Eur J Pharmacol. 2011 May 11;658(2-3):263-9. PubMed PMID: 21371468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical application of aloperine improves 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. AU - Yuan,Xiao-Ying, AU - Ma,Hui-Min, AU - Li,Rui-Zhi, AU - Wang,Rui-Yan, AU - Liu,Wei, AU - Guo,Jian-You, Y1 - 2011/03/01/ PY - 2010/07/07/received PY - 2010/10/10/revised PY - 2011/02/18/accepted PY - 2011/3/5/entrez PY - 2011/3/5/pubmed PY - 2011/7/26/medline SP - 263 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 658 IS - 2-3 N2 - Aloperine has been shown to inhibit 2,4-dinitrofluorobenzene (DNFB) induced allergic contact dermatitis in BALB/c mice. In the present study, we further investigated the effect of aloperine on DNFB-induced atopic dermatitis-like skin lesions in NC/Nga mice. NC/Nga mice elicited atopic dermatitis-like skin lesions after the topical application of DNFB. Aloperine treatment significantly inhibited dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E were also suppressed by aloperine treatment. Finally, cytokine (interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-13, tumor necrosis factor (TNF)-α and interferon (IFN)-γ) productions in ear biopsies homogenates were significantly elevated after DNFB challenge. Topical application of aloperine increased the immunosuppressive cytokine IL-10 level, while it reduced other cytokines production in a dose-dependent manner. Taken together, these data suggest that aloperine may be one of the effective therapeutic agents for the treatment of atopic dermatitis. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21371468/Topical_application_of_aloperine_improves_24_dinitrofluorobenzene_induced_atopic_dermatitis_like_skin_lesions_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00198-1 DB - PRIME DP - Unbound Medicine ER -