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[Effects of electroacupuncture of unilateral and bilateral "zusanli" (ST 36) on serum TNF-alpha, IL-1 and IL-4 levels in rats with chronic inflammatory pain].
Zhen Ci Yan Jiu. 2010 Dec; 35(6):429-32.ZC

Abstract

OBJECTIVE

To observe the effect of electroacupuncture (EA) on serum tumor necrosis factor-alpha (TNF-alpha), IL-1 and IL-4 levels in rats with chronic inflammatory pain, so as to investigate its underlying mechanism in relieving pain. Methods Forty-eight SD rats were randomized into control, model, EA-unilateral ST 36, and EA-bilateral ST 36 groups, with 12 rats in each. Chronic inflammatory pain model was established by intradermal injection of Freund's complete adjuvant (0.1 mL) into the right paw. EA (2 Hz/100 Hz, 1-2-3 mA) was applied to the unilateral "Zusanli" (ST 36) and bilateral "Zusanli" (ST 36) for 30 min, once every 3 days and continuously for 4 weeks. Serum TNF-alpha, IL-1 and IL-4 contents were detected by enzyme linked immunosorbent assay. Results Compared with the control group, serum TNF-alpha, IL-1 and IL-4 contents of the model group increased significantly (P < 0.01), while in comparison with the model group, the levels of the 3 indexes were decreased considerably in both unilateral and bilateral ST 36 groups (P < 0.01). No significant differences were found between the unilateral ST 36 and bilateral ST 36 groups in serum TNF-alpha, IL-1 and IL-4 contents (P > 0.05).

CONCLUSION

EA can effectively lower serum TNF-alpha, IL-1 and IL-4 levels in inflammatory pain rats, which may contribute to its effect in relieving inflammatory pain.

Authors+Show Affiliations

School of Acu-moxibustion and Massage, Beijing University of Chinese Medicine, Beijing 100029, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21375016

Citation

Wang, Wei-jun, et al. "[Effects of Electroacupuncture of Unilateral and Bilateral "zusanli" (ST 36) On Serum TNF-alpha, IL-1 and IL-4 Levels in Rats With Chronic Inflammatory Pain]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 35, no. 6, 2010, pp. 429-32.
Wang WJ, Lu J, Niu CS, et al. [Effects of electroacupuncture of unilateral and bilateral "zusanli" (ST 36) on serum TNF-alpha, IL-1 and IL-4 levels in rats with chronic inflammatory pain]. Zhen Ci Yan Jiu. 2010;35(6):429-32.
Wang, W. J., Lu, J., Niu, C. S., Huang, Y. R., Ma, Q., A, Y. G., Hao, H. W., Li, L. M., & Tu, Y. (2010). [Effects of electroacupuncture of unilateral and bilateral "zusanli" (ST 36) on serum TNF-alpha, IL-1 and IL-4 levels in rats with chronic inflammatory pain]. Zhen Ci Yan Jiu = Acupuncture Research, 35(6), 429-32.
Wang WJ, et al. [Effects of Electroacupuncture of Unilateral and Bilateral "zusanli" (ST 36) On Serum TNF-alpha, IL-1 and IL-4 Levels in Rats With Chronic Inflammatory Pain]. Zhen Ci Yan Jiu. 2010;35(6):429-32. PubMed PMID: 21375016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of electroacupuncture of unilateral and bilateral "zusanli" (ST 36) on serum TNF-alpha, IL-1 and IL-4 levels in rats with chronic inflammatory pain]. AU - Wang,Wei-jun, AU - Lu,Jun, AU - Niu,Chuan-sen, AU - Huang,Yi-ran, AU - Ma,Qing, AU - A,Ying-ge, AU - Hao,Hong-wei, AU - Li,Lu-ming, AU - Tu,Ya, PY - 2011/3/8/entrez PY - 2011/3/8/pubmed PY - 2011/3/23/medline SP - 429 EP - 32 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 35 IS - 6 N2 - OBJECTIVE: To observe the effect of electroacupuncture (EA) on serum tumor necrosis factor-alpha (TNF-alpha), IL-1 and IL-4 levels in rats with chronic inflammatory pain, so as to investigate its underlying mechanism in relieving pain. Methods Forty-eight SD rats were randomized into control, model, EA-unilateral ST 36, and EA-bilateral ST 36 groups, with 12 rats in each. Chronic inflammatory pain model was established by intradermal injection of Freund's complete adjuvant (0.1 mL) into the right paw. EA (2 Hz/100 Hz, 1-2-3 mA) was applied to the unilateral "Zusanli" (ST 36) and bilateral "Zusanli" (ST 36) for 30 min, once every 3 days and continuously for 4 weeks. Serum TNF-alpha, IL-1 and IL-4 contents were detected by enzyme linked immunosorbent assay. Results Compared with the control group, serum TNF-alpha, IL-1 and IL-4 contents of the model group increased significantly (P < 0.01), while in comparison with the model group, the levels of the 3 indexes were decreased considerably in both unilateral and bilateral ST 36 groups (P < 0.01). No significant differences were found between the unilateral ST 36 and bilateral ST 36 groups in serum TNF-alpha, IL-1 and IL-4 contents (P > 0.05). CONCLUSION: EA can effectively lower serum TNF-alpha, IL-1 and IL-4 levels in inflammatory pain rats, which may contribute to its effect in relieving inflammatory pain. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/21375016/[Effects_of_electroacupuncture_of_unilateral_and_bilateral_"zusanli"__ST_36__on_serum_TNF_alpha_IL_1_and_IL_4_levels_in_rats_with_chronic_inflammatory_pain]_ L2 - https://medlineplus.gov/nondrugpainmanagement.html DB - PRIME DP - Unbound Medicine ER -