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Elemental alteration, iron overloading and metallothionein induction in experimental hepatocarcinogenesis: a free radical-mediated process?
Toxicol Lett. 2011 May 30; 203(1):40-7.TL

Abstract

The azo-dye p-dimethylaminoazobenzene (p-DAB) is a potential tumor initiator in rodents, but the underlying mechanism is not clear. Following chronic feeding of the carcinogen for 3, 5 and 7 weeks, trace elemental status, free radical generation, oxidative damage, antioxidant profile were measured in male and female swiss albino mice. The feeding resulted in iron accumulation in male mice liver. No increase in iron level was observed in similarly exposed female mice. The results of this study suggest that p-DAB-induced iron accumulation in male mice with concomitant production of oxidative free radicals is an early event in the hepatocarcinogenic initiation. This occurs selectively in male mice and affects either directly or indirectly in development of chemically induced liver neoplasia. Again, that upregulation of metallothionein (MT) expression in association with increased free radical generation was demonstrated in male mice. Alteration of copper (Cu) and zinc (Zn) levels are described in the light of antioxidant profile in liver tissue. The current results thus provide evidence in support of iron accumulations producing oxidative damage, and enhanced metallothionein expression as possible contributors in the mode of action of p-DAB induced hepatocarcinogenesis.

Authors+Show Affiliations

UGC-DAE Consortium for Scientific Research, Kolkata Centre, III/LB-8, Salt Lake, Kolkata 700098, India. devduttm@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21376788

Citation

Mishra, Debadutta, et al. "Elemental Alteration, Iron Overloading and Metallothionein Induction in Experimental Hepatocarcinogenesis: a Free Radical-mediated Process?" Toxicology Letters, vol. 203, no. 1, 2011, pp. 40-7.
Mishra D, Sudarshan M, Chakraborty A. Elemental alteration, iron overloading and metallothionein induction in experimental hepatocarcinogenesis: a free radical-mediated process? Toxicol Lett. 2011;203(1):40-7.
Mishra, D., Sudarshan, M., & Chakraborty, A. (2011). Elemental alteration, iron overloading and metallothionein induction in experimental hepatocarcinogenesis: a free radical-mediated process? Toxicology Letters, 203(1), 40-7. https://doi.org/10.1016/j.toxlet.2011.02.018
Mishra D, Sudarshan M, Chakraborty A. Elemental Alteration, Iron Overloading and Metallothionein Induction in Experimental Hepatocarcinogenesis: a Free Radical-mediated Process. Toxicol Lett. 2011 May 30;203(1):40-7. PubMed PMID: 21376788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elemental alteration, iron overloading and metallothionein induction in experimental hepatocarcinogenesis: a free radical-mediated process? AU - Mishra,Debadutta, AU - Sudarshan,Mathummal, AU - Chakraborty,Anindita, Y1 - 2011/03/03/ PY - 2010/10/26/received PY - 2011/02/17/revised PY - 2011/02/21/accepted PY - 2011/3/8/entrez PY - 2011/3/8/pubmed PY - 2011/6/18/medline SP - 40 EP - 7 JF - Toxicology letters JO - Toxicol Lett VL - 203 IS - 1 N2 - The azo-dye p-dimethylaminoazobenzene (p-DAB) is a potential tumor initiator in rodents, but the underlying mechanism is not clear. Following chronic feeding of the carcinogen for 3, 5 and 7 weeks, trace elemental status, free radical generation, oxidative damage, antioxidant profile were measured in male and female swiss albino mice. The feeding resulted in iron accumulation in male mice liver. No increase in iron level was observed in similarly exposed female mice. The results of this study suggest that p-DAB-induced iron accumulation in male mice with concomitant production of oxidative free radicals is an early event in the hepatocarcinogenic initiation. This occurs selectively in male mice and affects either directly or indirectly in development of chemically induced liver neoplasia. Again, that upregulation of metallothionein (MT) expression in association with increased free radical generation was demonstrated in male mice. Alteration of copper (Cu) and zinc (Zn) levels are described in the light of antioxidant profile in liver tissue. The current results thus provide evidence in support of iron accumulations producing oxidative damage, and enhanced metallothionein expression as possible contributors in the mode of action of p-DAB induced hepatocarcinogenesis. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/21376788/Elemental_alteration_iron_overloading_and_metallothionein_induction_in_experimental_hepatocarcinogenesis:_a_free_radical_mediated_process L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(11)00088-9 DB - PRIME DP - Unbound Medicine ER -