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Metal-catalysed 1,2-diamination reactions.
Nat Chem. 2009 Jul; 1(4):269-75.NC

Abstract

The 1,2-diamine motif is present in a number of natural products with interesting biological activity and in many important pharmaceutical agents. Chiral 1,2-diamines are also widely used as the control elements in asymmetric synthesis and catalysis. Such compounds are thus an attractive target for the synthetic chemist. Although the diamination of an alkene seems an obvious route to these structures, far less research has been devoted to it than to the analogous dihydroxylation or aminohydroxylation reactions that are well-established processes in asymmetric synthesis. Here, we examine recent advances in metal-catalysed diamination reactions and their asymmetric variants. Given the prevalence of these structures, it seems likely that they will find extensive application in the construction of natural products and drug molecules in the near future.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Cardona F
Department of Organic Chemistry Ugo Schiff, Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles (HeteroBioLab), University of Florence, Via della Lastruccia 13, I-50019 Sesto Fiorentino, Italy.
Goti A
No affiliation info available

MeSH

AldehydesBiological ProductsCatalysisDiaminesEstersHydroxylationKetonesMetalsOrganic ChemicalsRhodium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21378869

Citation

Cardona, Francesca, and Andrea Goti. "Metal-catalysed 1,2-diamination Reactions." Nature Chemistry, vol. 1, no. 4, 2009, pp. 269-75.
Cardona F, Goti A. Metal-catalysed 1,2-diamination reactions. Nat Chem. 2009;1(4):269-75.
Cardona, F., & Goti, A. (2009). Metal-catalysed 1,2-diamination reactions. Nature Chemistry, 1(4), 269-75. https://doi.org/10.1038/nchem.256
Cardona F, Goti A. Metal-catalysed 1,2-diamination Reactions. Nat Chem. 2009;1(4):269-75. PubMed PMID: 21378869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metal-catalysed 1,2-diamination reactions. AU - Cardona,Francesca, AU - Goti,Andrea, Y1 - 2009/06/22/ PY - 2011/3/8/entrez PY - 2009/7/1/pubmed PY - 2011/5/6/medline SP - 269 EP - 75 JF - Nature chemistry JO - Nat Chem VL - 1 IS - 4 N2 - The 1,2-diamine motif is present in a number of natural products with interesting biological activity and in many important pharmaceutical agents. Chiral 1,2-diamines are also widely used as the control elements in asymmetric synthesis and catalysis. Such compounds are thus an attractive target for the synthetic chemist. Although the diamination of an alkene seems an obvious route to these structures, far less research has been devoted to it than to the analogous dihydroxylation or aminohydroxylation reactions that are well-established processes in asymmetric synthesis. Here, we examine recent advances in metal-catalysed diamination reactions and their asymmetric variants. Given the prevalence of these structures, it seems likely that they will find extensive application in the construction of natural products and drug molecules in the near future. SN - 1755-4349 UR - https://www.unboundmedicine.com/medline/citation/21378869/Metal_catalysed_12_diamination_reactions_ L2 - https://doi.org/10.1038/nchem.256 DB - PRIME DP - Unbound Medicine ER -