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Effect of the doping level on the biological stability of hydrogenated boron doped diamond electrodes.
Phys Chem Chem Phys. 2011 Mar 28; 13(12):5422-9.PC

Abstract

Fouling of electrode surfaces by electrode reaction products or by biological spectator species is known to inactivate electrochemical sensors and thus limit their use in biological conditions. Here we present an investigation on the stability of boron doped diamond (BDD) electrodes with different levels of doping. Three different doping levels were used (0.1, 1 and 5% in the carbon phase). The highly doped (5%) BDD is of particular interest as it is here used for the first time for biological applications. Three different redox reactions were examined based on their electrode reaction characteristics: ruthenium(III) hexaammine (outer sphere), ferrocyanide (surface dependent), dopamine (adsorption mediated). The effect of albumin at blood concentration was studied. All results were compared with glassy carbon. There were no significant differences for the outer sphere electrochemistry, but all the BDDs showed improved resistance to fouling for the ferrocyanide oxidation. The electrocatalytic activity of BBD towards dopamine oxidation increased with increased boron content. However, this appears to be due to a larger number of defect sites which also increases the vulnerability to fouling by albumin and by electrode reaction products and the 5% BDD had similar properties to glassy carbon in this regard. These results suggest that it is possible to optimise the BDD performance for specific applications and that the large potential window for BDD may be due, at least in part, to its relatively poor electrocatalytic activity.

Authors+Show Affiliations

Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. raphael.trouillon@m4x.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21380425

Citation

Trouillon, Raphaël, et al. "Effect of the Doping Level On the Biological Stability of Hydrogenated Boron Doped Diamond Electrodes." Physical Chemistry Chemical Physics : PCCP, vol. 13, no. 12, 2011, pp. 5422-9.
Trouillon R, O'Hare D, Einaga Y. Effect of the doping level on the biological stability of hydrogenated boron doped diamond electrodes. Phys Chem Chem Phys. 2011;13(12):5422-9.
Trouillon, R., O'Hare, D., & Einaga, Y. (2011). Effect of the doping level on the biological stability of hydrogenated boron doped diamond electrodes. Physical Chemistry Chemical Physics : PCCP, 13(12), 5422-9. https://doi.org/10.1039/c0cp02420a
Trouillon R, O'Hare D, Einaga Y. Effect of the Doping Level On the Biological Stability of Hydrogenated Boron Doped Diamond Electrodes. Phys Chem Chem Phys. 2011 Mar 28;13(12):5422-9. PubMed PMID: 21380425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the doping level on the biological stability of hydrogenated boron doped diamond electrodes. AU - Trouillon,Raphaël, AU - O'Hare,Danny, AU - Einaga,Yasuaki, Y1 - 2011/03/07/ PY - 2011/3/8/entrez PY - 2011/3/8/pubmed PY - 2011/6/15/medline SP - 5422 EP - 9 JF - Physical chemistry chemical physics : PCCP JO - Phys Chem Chem Phys VL - 13 IS - 12 N2 - Fouling of electrode surfaces by electrode reaction products or by biological spectator species is known to inactivate electrochemical sensors and thus limit their use in biological conditions. Here we present an investigation on the stability of boron doped diamond (BDD) electrodes with different levels of doping. Three different doping levels were used (0.1, 1 and 5% in the carbon phase). The highly doped (5%) BDD is of particular interest as it is here used for the first time for biological applications. Three different redox reactions were examined based on their electrode reaction characteristics: ruthenium(III) hexaammine (outer sphere), ferrocyanide (surface dependent), dopamine (adsorption mediated). The effect of albumin at blood concentration was studied. All results were compared with glassy carbon. There were no significant differences for the outer sphere electrochemistry, but all the BDDs showed improved resistance to fouling for the ferrocyanide oxidation. The electrocatalytic activity of BBD towards dopamine oxidation increased with increased boron content. However, this appears to be due to a larger number of defect sites which also increases the vulnerability to fouling by albumin and by electrode reaction products and the 5% BDD had similar properties to glassy carbon in this regard. These results suggest that it is possible to optimise the BDD performance for specific applications and that the large potential window for BDD may be due, at least in part, to its relatively poor electrocatalytic activity. SN - 1463-9084 UR - https://www.unboundmedicine.com/medline/citation/21380425/Effect_of_the_doping_level_on_the_biological_stability_of_hydrogenated_boron_doped_diamond_electrodes_ L2 - https://doi.org/10.1039/c0cp02420a DB - PRIME DP - Unbound Medicine ER -