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[Simultaneous determination of delta-9-tetrahydrocannabinol cannabidiol and cannabinol in edible oil using ultra performance liquid chromatography-tandem mass spectrometry].
Se Pu 2010; 28(11):1015-9SP

Abstract

A method for the simultaneous determination of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in edible oil was developed using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The target compounds were extracted with methanol, purified by an LC-Alumina-N solid phase extraction cartridge, separated and detected by the UPLC-MS/MS. Quantitative analysis was corrected by an isotope internal standard method using delta-9-THC-D3 as internal standard. Average recoveries for the target compounds varied from 68.0% to 101.6% with the relative standard deviations ranging from 7.0% to 20.1% at three spiked levels. The limits of detection (LOD) of the method were from 0.06-0.17 microg/kg and the limits of quantification (LOQ) were in the range of 0.20-0.52 microg/kg. The results showed that the method is able to meet the requirements for the simultaneous determination of THC, CBD and CBN in edible oil.

Authors+Show Affiliations

Ningbo Academy of Product Quality Supervision & Inspection, Ningbo 315041, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21381415

Citation

Zhang, Aizhi, et al. "[Simultaneous Determination of Delta-9-tetrahydrocannabinol Cannabidiol and Cannabinol in Edible Oil Using Ultra Performance Liquid Chromatography-tandem Mass Spectrometry]." Se Pu = Chinese Journal of Chromatography, vol. 28, no. 11, 2010, pp. 1015-9.
Zhang A, Wang Q, Mo S. [Simultaneous determination of delta-9-tetrahydrocannabinol cannabidiol and cannabinol in edible oil using ultra performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2010;28(11):1015-9.
Zhang, A., Wang, Q., & Mo, S. (2010). [Simultaneous determination of delta-9-tetrahydrocannabinol cannabidiol and cannabinol in edible oil using ultra performance liquid chromatography-tandem mass spectrometry]. Se Pu = Chinese Journal of Chromatography, 28(11), pp. 1015-9.
Zhang A, Wang Q, Mo S. [Simultaneous Determination of Delta-9-tetrahydrocannabinol Cannabidiol and Cannabinol in Edible Oil Using Ultra Performance Liquid Chromatography-tandem Mass Spectrometry]. Se Pu. 2010;28(11):1015-9. PubMed PMID: 21381415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Simultaneous determination of delta-9-tetrahydrocannabinol cannabidiol and cannabinol in edible oil using ultra performance liquid chromatography-tandem mass spectrometry]. AU - Zhang,Aizhi, AU - Wang,Quanlin, AU - Mo,Shijie, PY - 2011/3/9/entrez PY - 2011/3/9/pubmed PY - 2012/2/14/medline SP - 1015 EP - 9 JF - Se pu = Chinese journal of chromatography JO - Se Pu VL - 28 IS - 11 N2 - A method for the simultaneous determination of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in edible oil was developed using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The target compounds were extracted with methanol, purified by an LC-Alumina-N solid phase extraction cartridge, separated and detected by the UPLC-MS/MS. Quantitative analysis was corrected by an isotope internal standard method using delta-9-THC-D3 as internal standard. Average recoveries for the target compounds varied from 68.0% to 101.6% with the relative standard deviations ranging from 7.0% to 20.1% at three spiked levels. The limits of detection (LOD) of the method were from 0.06-0.17 microg/kg and the limits of quantification (LOQ) were in the range of 0.20-0.52 microg/kg. The results showed that the method is able to meet the requirements for the simultaneous determination of THC, CBD and CBN in edible oil. SN - 1000-8713 UR - https://www.unboundmedicine.com/medline/citation/21381415/abstract/[Simultaneous_determination_of_delta_9_tetrahydrocannabinol_cannabidiol_and_cannabinol_in_edible_oil_using_ultra_performance_liquid_chromatography_tandem_mass_spectrometry]_ DB - PRIME DP - Unbound Medicine ER -