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Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation.
Curr Gastroenterol Rep 2011; 13(3):265-70CG

Abstract

Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients. Long-term follow-up studies show that today meconium ileus is not a risk factor for impaired nutritional status, pulmonary function, or survival. DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored. Diagnosis of DIOS is based on suggestive symptoms, with a right lower quadrant mass confirmed on abdominal radiography, whereas symptoms of constipation are milder and of longer standing. In DIOS, early aggressive laxative treatment with oral laxatives (polyethylene glycol) or intestinal lavage with balanced osmotic electrolyte solution and rehydration is required, which now makes the need for surgical interventions rare. Constipation can generally be well controlled with polyethylene glycol maintenance treatment.

Authors+Show Affiliations

Department of Pediatric Gastroenterology [KE.04.133.1], University Medical Center Utrecht, Postbox 85090, 3508 AB Utrecht, The Netherlands. h.p.j.vanderdoef@umcutrecht.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21384135

Citation

van der Doef, Hubert P J., et al. "Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation." Current Gastroenterology Reports, vol. 13, no. 3, 2011, pp. 265-70.
van der Doef HP, Kokke FT, van der Ent CK, et al. Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. Curr Gastroenterol Rep. 2011;13(3):265-70.
van der Doef, H. P., Kokke, F. T., van der Ent, C. K., & Houwen, R. H. (2011). Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. Current Gastroenterology Reports, 13(3), pp. 265-70. doi:10.1007/s11894-011-0185-9.
van der Doef HP, et al. Intestinal Obstruction Syndromes in Cystic Fibrosis: Meconium Ileus, Distal Intestinal Obstruction Syndrome, and Constipation. Curr Gastroenterol Rep. 2011;13(3):265-70. PubMed PMID: 21384135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation. AU - van der Doef,Hubert P J, AU - Kokke,Freddy T M, AU - van der Ent,Cornelis K, AU - Houwen,Roderick H J, PY - 2011/3/9/entrez PY - 2011/3/9/pubmed PY - 2011/10/7/medline SP - 265 EP - 70 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 13 IS - 3 N2 - Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients. Long-term follow-up studies show that today meconium ileus is not a risk factor for impaired nutritional status, pulmonary function, or survival. DIOS and constipation are frequently seen in cystic fibrosis patients, especially later in life; genetic, dietary, and other associations have been explored. Diagnosis of DIOS is based on suggestive symptoms, with a right lower quadrant mass confirmed on abdominal radiography, whereas symptoms of constipation are milder and of longer standing. In DIOS, early aggressive laxative treatment with oral laxatives (polyethylene glycol) or intestinal lavage with balanced osmotic electrolyte solution and rehydration is required, which now makes the need for surgical interventions rare. Constipation can generally be well controlled with polyethylene glycol maintenance treatment. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/21384135/Intestinal_obstruction_syndromes_in_cystic_fibrosis:_meconium_ileus_distal_intestinal_obstruction_syndrome_and_constipation_ L2 - https://dx.doi.org/10.1007/s11894-011-0185-9 DB - PRIME DP - Unbound Medicine ER -