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The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration.
Neuroimage. 2011 Jun 01; 56(3):1814-21.N

Abstract

Despite growing clinical and neurobiological interest in the brain mechanisms that process emotion in music, these mechanisms remain incompletely understood. Patients with frontotemporal lobar degeneration (FTLD) frequently exhibit clinical syndromes that illustrate the effects of breakdown in emotional and social functioning. Here we investigated the neuroanatomical substrate for recognition of musical emotion in a cohort of 26 patients with FTLD (16 with behavioural variant frontotemporal dementia, bvFTD, 10 with semantic dementia, SemD) using voxel-based morphometry. On neuropsychological evaluation, patients with FTLD showed deficient recognition of canonical emotions (happiness, sadness, anger and fear) from music as well as faces and voices compared with healthy control subjects. Impaired recognition of emotions from music was specifically associated with grey matter loss in a distributed cerebral network including insula, orbitofrontal cortex, anterior cingulate and medial prefrontal cortex, anterior temporal and more posterior temporal and parietal cortices, amygdala and the subcortical mesolimbic system. This network constitutes an essential brain substrate for recognition of musical emotion that overlaps with brain regions previously implicated in coding emotional value, behavioural context, conceptual knowledge and theory of mind. Musical emotion recognition may probe the interface of these processes, delineating a profile of brain damage that is essential for the abstraction of complex social emotions.

Authors+Show Affiliations

Dementia Research Centre, Institute of Neurology, University College London, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21385617

Citation

Omar, Rohani, et al. "The Structural Neuroanatomy of Music Emotion Recognition: Evidence From Frontotemporal Lobar Degeneration." NeuroImage, vol. 56, no. 3, 2011, pp. 1814-21.
Omar R, Henley SM, Bartlett JW, et al. The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. Neuroimage. 2011;56(3):1814-21.
Omar, R., Henley, S. M., Bartlett, J. W., Hailstone, J. C., Gordon, E., Sauter, D. A., Frost, C., Scott, S. K., & Warren, J. D. (2011). The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. NeuroImage, 56(3), 1814-21. https://doi.org/10.1016/j.neuroimage.2011.03.002
Omar R, et al. The Structural Neuroanatomy of Music Emotion Recognition: Evidence From Frontotemporal Lobar Degeneration. Neuroimage. 2011 Jun 1;56(3):1814-21. PubMed PMID: 21385617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The structural neuroanatomy of music emotion recognition: evidence from frontotemporal lobar degeneration. AU - Omar,Rohani, AU - Henley,Susie M D, AU - Bartlett,Jonathan W, AU - Hailstone,Julia C, AU - Gordon,Elizabeth, AU - Sauter,Disa A, AU - Frost,Chris, AU - Scott,Sophie K, AU - Warren,Jason D, Y1 - 2011/03/06/ PY - 2010/10/19/received PY - 2011/02/14/revised PY - 2011/03/01/accepted PY - 2011/3/10/entrez PY - 2011/3/10/pubmed PY - 2011/7/26/medline SP - 1814 EP - 21 JF - NeuroImage JO - Neuroimage VL - 56 IS - 3 N2 - Despite growing clinical and neurobiological interest in the brain mechanisms that process emotion in music, these mechanisms remain incompletely understood. Patients with frontotemporal lobar degeneration (FTLD) frequently exhibit clinical syndromes that illustrate the effects of breakdown in emotional and social functioning. Here we investigated the neuroanatomical substrate for recognition of musical emotion in a cohort of 26 patients with FTLD (16 with behavioural variant frontotemporal dementia, bvFTD, 10 with semantic dementia, SemD) using voxel-based morphometry. On neuropsychological evaluation, patients with FTLD showed deficient recognition of canonical emotions (happiness, sadness, anger and fear) from music as well as faces and voices compared with healthy control subjects. Impaired recognition of emotions from music was specifically associated with grey matter loss in a distributed cerebral network including insula, orbitofrontal cortex, anterior cingulate and medial prefrontal cortex, anterior temporal and more posterior temporal and parietal cortices, amygdala and the subcortical mesolimbic system. This network constitutes an essential brain substrate for recognition of musical emotion that overlaps with brain regions previously implicated in coding emotional value, behavioural context, conceptual knowledge and theory of mind. Musical emotion recognition may probe the interface of these processes, delineating a profile of brain damage that is essential for the abstraction of complex social emotions. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/21385617/The_structural_neuroanatomy_of_music_emotion_recognition:_evidence_from_frontotemporal_lobar_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(11)00261-8 DB - PRIME DP - Unbound Medicine ER -