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Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS.
J Breath Res. 2008 Dec; 2(4):046003.JB

Abstract

The sensitivity of selected ion flow tube mass spectrometry, SIFT-MS, has been increased such that it is now possible to detect metabolites present at a part-per-billion, ppb, level in single breath exhalations. However, to utilize this improved sensitivity, the overlaps (coincidences) of those ions resulting from interfering reactions of impurity precursor ions with some breath metabolites present at higher concentrations with the analytical product ions characteristic of particular metabolites must be accounted for. In this paper, the full reaction schemes are presented for SIFT-MS analyses of three volatile potential cancer biomarkers in exhaled breath, namely formaldehyde, HCHO, acetaldehyde, CH(3)CHO and 2-propanol, CH(3)CH(OH)CH(3), which identify both the characteristic SIFT-MS product ions for these compounds and the interfering ions at the same mass-to-charge, m/z, values. An absolute quantification equation accounting for these interferences is formulated and appropriate entries into the SIFT-MS kinetics library are indicated. It is shown that when using H(3)O(+) to quantify formaldehyde and acetaldehyde the reactions of impurity O(2)(+) ions with methanol and ethanol (always present in breath) must be accounted for and that the quantification of acetaldehyde must avoid the interference of the CO(2) present in exhaled breath. Finally, it is indicated that the analysis of 2-propanol can be achieved using both H(3)O(+) and NO(+) precursor ions.

Authors+Show Affiliations

J Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, 182 23, Prague 8, Czech Republic. Institute for Science and Technology in Medicine, School of Medicine, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, ST4 7QB, UK.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21386190

Citation

Spaněl, Patrik, and David Smith. "Quantification of Trace Levels of the Potential Cancer Biomarkers Formaldehyde, Acetaldehyde and Propanol in Breath By SIFT-MS." Journal of Breath Research, vol. 2, no. 4, 2008, p. 046003.
Spaněl P, Smith D. Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. J Breath Res. 2008;2(4):046003.
Spaněl, P., & Smith, D. (2008). Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. Journal of Breath Research, 2(4), 046003. https://doi.org/10.1088/1752-7155/2/4/046003
Spaněl P, Smith D. Quantification of Trace Levels of the Potential Cancer Biomarkers Formaldehyde, Acetaldehyde and Propanol in Breath By SIFT-MS. J Breath Res. 2008;2(4):046003. PubMed PMID: 21386190.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS. AU - Spaněl,Patrik, AU - Smith,David, Y1 - 2008/07/24/ PY - 2011/3/10/entrez PY - 2008/12/1/pubmed PY - 2008/12/1/medline SP - 046003 EP - 046003 JF - Journal of breath research JO - J Breath Res VL - 2 IS - 4 N2 - The sensitivity of selected ion flow tube mass spectrometry, SIFT-MS, has been increased such that it is now possible to detect metabolites present at a part-per-billion, ppb, level in single breath exhalations. However, to utilize this improved sensitivity, the overlaps (coincidences) of those ions resulting from interfering reactions of impurity precursor ions with some breath metabolites present at higher concentrations with the analytical product ions characteristic of particular metabolites must be accounted for. In this paper, the full reaction schemes are presented for SIFT-MS analyses of three volatile potential cancer biomarkers in exhaled breath, namely formaldehyde, HCHO, acetaldehyde, CH(3)CHO and 2-propanol, CH(3)CH(OH)CH(3), which identify both the characteristic SIFT-MS product ions for these compounds and the interfering ions at the same mass-to-charge, m/z, values. An absolute quantification equation accounting for these interferences is formulated and appropriate entries into the SIFT-MS kinetics library are indicated. It is shown that when using H(3)O(+) to quantify formaldehyde and acetaldehyde the reactions of impurity O(2)(+) ions with methanol and ethanol (always present in breath) must be accounted for and that the quantification of acetaldehyde must avoid the interference of the CO(2) present in exhaled breath. Finally, it is indicated that the analysis of 2-propanol can be achieved using both H(3)O(+) and NO(+) precursor ions. SN - 1752-7155 UR - https://www.unboundmedicine.com/medline/citation/21386190/Quantification_of_trace_levels_of_the_potential_cancer_biomarkers_formaldehyde_acetaldehyde_and_propanol_in_breath_by_SIFT_MS_ L2 - https://doi.org/10.1088/1752-7155/2/4/046003 DB - PRIME DP - Unbound Medicine ER -
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