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Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis.
Retina 2011; 31(4):717-23R

Abstract

PURPOSE

To compare the spectral-domain optical coherence tomography (SD-OCT) findings of the acute lesions of multifocal choroiditis (MFC) with those of new-onset myopic choroidal neovascularization (CNV).

METHODS

Observational case series. A retrospective review comparing the SD-OCT findings of the acute lesions of MFC with those of early myopic CNV. Spectral-domain optical coherence tomography findings in two female patients and one male patient presenting with acute inflammatory lesions of MFC were compared with those of new-onset CNV in three patients with myopic macular degeneration. Each patient underwent a comprehensive eye examination, fundus photography, and fluorescein angiography on the initial visit. The patients underwent SD-OCT scanning at baseline and at follow-up visits using image registration and eye tracking.

RESULTS

Spectral-domain optical coherence tomography imaging of the acute lesions of MFC showed drusenlike material between the retinal pigment epithelium and the Bruch membrane, presumed vitreous cells, and localized choroidal hyperreflectivity below the subretinal pigment epithelial material. These SD-OCT findings were not usually present in the eyes with myopic CNV. The subretinal pigment epithelial material corresponded to acute lesions found on color photographs and fluorescein angiography. The subretinal pigment epithelial material and choroidal hyperreflectivity appeared to improve after treatment with antiinflammatory or anti-vascular endothelial growth factor therapy. In contrast, SD-OCT in the patients with myopic CNV showed a very thin choroid, a posterior staphyloma, and a Type 2 (subretinal) neovascular pattern.

CONCLUSION

The acute lesions of MFC can be difficult to distinguish from myopic CNV based on clinical examination and fluorescein angiography. However, the inflammatory lesions of MFC can demonstrate characteristic SD-OCT findings not seen with myopic CNV. These SD-OCT findings may help to differentiate these two entities that typically require different treatments.

Authors+Show Affiliations

Vitreous Retina Macula Consultants of New York, New York, New York 10022, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21386760

Citation

Vance, Sushma K., et al. "Characteristic Spectral-domain Optical Coherence Tomography Findings of Multifocal Choroiditis." Retina (Philadelphia, Pa.), vol. 31, no. 4, 2011, pp. 717-23.
Vance SK, Khan S, Klancnik JM, et al. Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina (Philadelphia, Pa). 2011;31(4):717-23.
Vance, S. K., Khan, S., Klancnik, J. M., & Freund, K. B. (2011). Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. Retina (Philadelphia, Pa.), 31(4), pp. 717-23. doi:10.1097/IAE.0b013e318203c1ef.
Vance SK, et al. Characteristic Spectral-domain Optical Coherence Tomography Findings of Multifocal Choroiditis. Retina (Philadelphia, Pa). 2011;31(4):717-23. PubMed PMID: 21386760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristic spectral-domain optical coherence tomography findings of multifocal choroiditis. AU - Vance,Sushma K, AU - Khan,Samira, AU - Klancnik,James M, AU - Freund,K Bailey, PY - 2011/3/10/entrez PY - 2011/3/10/pubmed PY - 2011/12/13/medline SP - 717 EP - 23 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 31 IS - 4 N2 - PURPOSE: To compare the spectral-domain optical coherence tomography (SD-OCT) findings of the acute lesions of multifocal choroiditis (MFC) with those of new-onset myopic choroidal neovascularization (CNV). METHODS: Observational case series. A retrospective review comparing the SD-OCT findings of the acute lesions of MFC with those of early myopic CNV. Spectral-domain optical coherence tomography findings in two female patients and one male patient presenting with acute inflammatory lesions of MFC were compared with those of new-onset CNV in three patients with myopic macular degeneration. Each patient underwent a comprehensive eye examination, fundus photography, and fluorescein angiography on the initial visit. The patients underwent SD-OCT scanning at baseline and at follow-up visits using image registration and eye tracking. RESULTS: Spectral-domain optical coherence tomography imaging of the acute lesions of MFC showed drusenlike material between the retinal pigment epithelium and the Bruch membrane, presumed vitreous cells, and localized choroidal hyperreflectivity below the subretinal pigment epithelial material. These SD-OCT findings were not usually present in the eyes with myopic CNV. The subretinal pigment epithelial material corresponded to acute lesions found on color photographs and fluorescein angiography. The subretinal pigment epithelial material and choroidal hyperreflectivity appeared to improve after treatment with antiinflammatory or anti-vascular endothelial growth factor therapy. In contrast, SD-OCT in the patients with myopic CNV showed a very thin choroid, a posterior staphyloma, and a Type 2 (subretinal) neovascular pattern. CONCLUSION: The acute lesions of MFC can be difficult to distinguish from myopic CNV based on clinical examination and fluorescein angiography. However, the inflammatory lesions of MFC can demonstrate characteristic SD-OCT findings not seen with myopic CNV. These SD-OCT findings may help to differentiate these two entities that typically require different treatments. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/21386760/Characteristic_spectral_domain_optical_coherence_tomography_findings_of_multifocal_choroiditis_ L2 - http://dx.doi.org/10.1097/IAE.0b013e318203c1ef DB - PRIME DP - Unbound Medicine ER -