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[Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes].
Klin Wochenschr. 1990 Jan 19; 68(2):107-15.KW

Abstract

Pain syndromes of the lumbar spine are one of the main problems in orthopedic practice. The therapeutic effect of NSAIDs is not subject to doubt in this connection. But considering that the application of NSAIDs is frequently associated with side effects, a reduction of dosage would be to the patient's benefit. Clinical studies have shown that concomitant treatment with vitamins B1, B6, B12 and diclofenac leads to a more efficient pain relief than treatment using diclofenac alone and thus provides the possibility of saving NSAIDs. This clinical trial was carried out in order to determine whether these results can also be achieved when a reduced dosage of diclofenac (75 mg daily) is used. 123 patients with acute pain syndromes of the lumbar spine were treated with either B-vitamins and diclofenac or diclofenac alone for a maximum of 7 days. There was the option to terminate therapy in the trial after 3-4 days in the case of total pain relief. 45 patients could stop the treatment due to remission of symptoms. 30 patients belonged to the combination therapy group, the other 15 took diclofenac alone; this difference is statistically significant (p less than 0.05). All parameters concerning pain relief and movement of the vertebral column showed statistically significant differences in favour of the B-vitamin-diclofenac-combination, too. The results document the positive influence of B-vitamins on painful vertebral syndromes and indicate that B-vitamins contribute to saving of NSAIDs by shortening the treatment time and reducing daily NSAID-dosage.

Authors+Show Affiliations

Deutsches Krebsforschungszentrum Heidelberg.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

2138683

Citation

Kuhlwein, A, et al. "[Reduced Diclofenac Administration By B Vitamins: Results of a Randomized Double-blind Study With Reduced Daily Doses of Diclofenac (75 Mg Diclofenac Versus 75 Mg Diclofenac Plus B Vitamins) in Acute Lumbar Vertebral Syndromes]." Klinische Wochenschrift, vol. 68, no. 2, 1990, pp. 107-15.
Kuhlwein A, Meyer HJ, Koehler CO. [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klin Wochenschr. 1990;68(2):107-15.
Kuhlwein, A., Meyer, H. J., & Koehler, C. O. (1990). [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. Klinische Wochenschrift, 68(2), 107-15.
Kuhlwein A, Meyer HJ, Koehler CO. [Reduced Diclofenac Administration By B Vitamins: Results of a Randomized Double-blind Study With Reduced Daily Doses of Diclofenac (75 Mg Diclofenac Versus 75 Mg Diclofenac Plus B Vitamins) in Acute Lumbar Vertebral Syndromes]. Klin Wochenschr. 1990 Jan 19;68(2):107-15. PubMed PMID: 2138683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Reduced diclofenac administration by B vitamins: results of a randomized double-blind study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitamins) in acute lumbar vertebral syndromes]. AU - Kuhlwein,A, AU - Meyer,H J, AU - Koehler,C O, PY - 1990/1/19/pubmed PY - 1990/1/19/medline PY - 1990/1/19/entrez SP - 107 EP - 15 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 68 IS - 2 N2 - Pain syndromes of the lumbar spine are one of the main problems in orthopedic practice. The therapeutic effect of NSAIDs is not subject to doubt in this connection. But considering that the application of NSAIDs is frequently associated with side effects, a reduction of dosage would be to the patient's benefit. Clinical studies have shown that concomitant treatment with vitamins B1, B6, B12 and diclofenac leads to a more efficient pain relief than treatment using diclofenac alone and thus provides the possibility of saving NSAIDs. This clinical trial was carried out in order to determine whether these results can also be achieved when a reduced dosage of diclofenac (75 mg daily) is used. 123 patients with acute pain syndromes of the lumbar spine were treated with either B-vitamins and diclofenac or diclofenac alone for a maximum of 7 days. There was the option to terminate therapy in the trial after 3-4 days in the case of total pain relief. 45 patients could stop the treatment due to remission of symptoms. 30 patients belonged to the combination therapy group, the other 15 took diclofenac alone; this difference is statistically significant (p less than 0.05). All parameters concerning pain relief and movement of the vertebral column showed statistically significant differences in favour of the B-vitamin-diclofenac-combination, too. The results document the positive influence of B-vitamins on painful vertebral syndromes and indicate that B-vitamins contribute to saving of NSAIDs by shortening the treatment time and reducing daily NSAID-dosage. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2138683/[Reduced_diclofenac_administration_by_B_vitamins:_results_of_a_randomized_double_blind_study_with_reduced_daily_doses_of_diclofenac__75_mg_diclofenac_versus_75_mg_diclofenac_plus_B_vitamins__in_acute_lumbar_vertebral_syndromes]_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -