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[Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study].
Klin Wochenschr. 1990 Jan 19; 68(2):116-20.KW

Abstract

Several clinical trials have shown that the duration of treatment of painful vertebral syndromes can be shortened by using a combination of vitamins B1, B6, B12 and diclofenac instead of diclofenac. In addition, a more efficient pain relief could be achieved by the combination therapy. In order to confirm these results, we compared the clinical efficacy of diclofenac (25 mg) and a combination preparation with diclofenac (25 mg) plus vitamins B1 (thiamine nitrate 50 mg), B6 (pyridoxine hydrochloride 50 mg) and B12 (cyanocobalamin 0.25 mg) in a multicentric randomized double-blind study including 418 patients. All patients received 3 x 2 capsules daily for a maximum of 2 weeks. In case of total pain relief, therapy should be discontinued after one week. Data of 376 patients could be evaluated. 53 out of 184 patients receiving the combination and 48 out of 192 patients treated with diclofenac alone could stop therapy due to sufficient pain relief after one week. The evaluation of the "Hoppe Pain Questionnaire" and the data concerning pain intensity also revealed better results for the combination preparation. The differences in favour of the B-vitamin-diclofenac-combination were statistically significant in patients with severe pain at the beginning of therapy. Considering undesirable side-effects (symptoms in 70 out of 418 patients) there were no significant differences between the two medications. This clinical trial provides further evidence that the combination therapy with diclofenac plus B-vitamins is more effective than diclofenac alone for the treatment of painful vertebral syndromes.

Authors+Show Affiliations

Weserberglandklinik, Höxter.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

ger

PubMed ID

2138684

Citation

Brüggemann, G, et al. "[Results of a Double-blind Study of Diclofenac + Vitamin B1, B6, B12 Versus Diclofenac in Patients With Acute Pain of the Lumbar Vertebrae. a Multicenter Study]." Klinische Wochenschrift, vol. 68, no. 2, 1990, pp. 116-20.
Brüggemann G, Koehler CO, Koch EM. [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klin Wochenschr. 1990;68(2):116-20.
Brüggemann, G., Koehler, C. O., & Koch, E. M. (1990). [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. Klinische Wochenschrift, 68(2), 116-20.
Brüggemann G, Koehler CO, Koch EM. [Results of a Double-blind Study of Diclofenac + Vitamin B1, B6, B12 Versus Diclofenac in Patients With Acute Pain of the Lumbar Vertebrae. a Multicenter Study]. Klin Wochenschr. 1990 Jan 19;68(2):116-20. PubMed PMID: 2138684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebrae. A multicenter study]. AU - Brüggemann,G, AU - Koehler,C O, AU - Koch,E M, PY - 1990/1/19/pubmed PY - 1990/1/19/medline PY - 1990/1/19/entrez SP - 116 EP - 20 JF - Klinische Wochenschrift JO - Klin. Wochenschr. VL - 68 IS - 2 N2 - Several clinical trials have shown that the duration of treatment of painful vertebral syndromes can be shortened by using a combination of vitamins B1, B6, B12 and diclofenac instead of diclofenac. In addition, a more efficient pain relief could be achieved by the combination therapy. In order to confirm these results, we compared the clinical efficacy of diclofenac (25 mg) and a combination preparation with diclofenac (25 mg) plus vitamins B1 (thiamine nitrate 50 mg), B6 (pyridoxine hydrochloride 50 mg) and B12 (cyanocobalamin 0.25 mg) in a multicentric randomized double-blind study including 418 patients. All patients received 3 x 2 capsules daily for a maximum of 2 weeks. In case of total pain relief, therapy should be discontinued after one week. Data of 376 patients could be evaluated. 53 out of 184 patients receiving the combination and 48 out of 192 patients treated with diclofenac alone could stop therapy due to sufficient pain relief after one week. The evaluation of the "Hoppe Pain Questionnaire" and the data concerning pain intensity also revealed better results for the combination preparation. The differences in favour of the B-vitamin-diclofenac-combination were statistically significant in patients with severe pain at the beginning of therapy. Considering undesirable side-effects (symptoms in 70 out of 418 patients) there were no significant differences between the two medications. This clinical trial provides further evidence that the combination therapy with diclofenac plus B-vitamins is more effective than diclofenac alone for the treatment of painful vertebral syndromes. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2138684/[Results_of_a_double_blind_study_of_diclofenac_+_vitamin_B1_B6_B12_versus_diclofenac_in_patients_with_acute_pain_of_the_lumbar_vertebrae__A_multicenter_study]_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -