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Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities.
Nat Prod Res. 2011 Mar; 25(5):526-41.NP

Abstract

Salvia officinalis L. oils were isolated from the plant's commercial dried aerial parts, by hydrodistillation, with different distillation times. The essential oils were analysed by gas chromatography and gas chromatography-mass spectrometry. The antioxidant ability was measured using a free radical scavenging activity assay using 2,2-diphenyl-1-picrylhydrazyl (DPPH), a thiobarbituric acid reactive substances (TBARS) assay, a deoxyribose assay for the scavenging of hydroxyl radical, an assay for site-specific actions and a 5-lipoxygenase assay. Antibacterial activity was determined by the agar diffusion method. 1,8-Cineole, α-pinene and camphor were the dominant components of all the essential oils. The different hydrodistillation times did not affect the oil yield nor the relative amount of the oil components. The time of hydrodistillation influenced the antioxidant activity. With the DPPH method, the oils isolated for 2 and 3 h were stronger free radical scavengers, while with the TBARS method, the highest antioxidant values were obtained in the oils isolated for 30 min, 2 and 3 h. Hydroxyl radical scavenging and lipoxygenase activity assays showed the best results with oils isolated for 1 and 3 h. With the deoxyribose method, sage oils at concentrations <1000 mg L(-1) showed better activity than mannitol. The essential oil of S. officinalis showed very weak antimicrobial activity.

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Authors+Show Affiliations

Miguel G
Universidade do Algarve, Faculdade de Ciências e Tecnologia, DQF, Edifício 8, Campus de Gambelas 8005-139 Faro, Portugal. mgmiguel@ualg.pt
Cruz C
No affiliation info available
Faleiro ML
No affiliation info available
Simões MT
No affiliation info available
Figueiredo AC
No affiliation info available
Barroso JG
No affiliation info available
Pedro LG
No affiliation info available

MeSH

Anti-Infective AgentsAntioxidantsBicyclic MonoterpenesCamphorCyclohexanolsDistillationEucalyptolGas Chromatography-Mass SpectrometryMonoterpenesOils, VolatileSalvia officinalisThiobarbituric Acid Reactive SubstancesTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21391115

Citation

Miguel, G, et al. "Salvia Officinalis L. Essential Oils: Effect of Hydrodistillation Time On the Chemical Composition, Antioxidant and Antimicrobial Activities." Natural Product Research, vol. 25, no. 5, 2011, pp. 526-41.
Miguel G, Cruz C, Faleiro ML, et al. Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities. Nat Prod Res. 2011;25(5):526-41.
Miguel, G., Cruz, C., Faleiro, M. L., Simões, M. T., Figueiredo, A. C., Barroso, J. G., & Pedro, L. G. (2011). Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities. Natural Product Research, 25(5), 526-41. https://doi.org/10.1080/14786419.2010.499513
Miguel G, et al. Salvia Officinalis L. Essential Oils: Effect of Hydrodistillation Time On the Chemical Composition, Antioxidant and Antimicrobial Activities. Nat Prod Res. 2011;25(5):526-41. PubMed PMID: 21391115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salvia officinalis L. essential oils: effect of hydrodistillation time on the chemical composition, antioxidant and antimicrobial activities. AU - Miguel,G, AU - Cruz,C, AU - Faleiro,M L, AU - Simões,M T F, AU - Figueiredo,A C, AU - Barroso,J G, AU - Pedro,L G, PY - 2011/3/11/entrez PY - 2011/3/11/pubmed PY - 2011/7/8/medline SP - 526 EP - 41 JF - Natural product research JO - Nat Prod Res VL - 25 IS - 5 N2 - Salvia officinalis L. oils were isolated from the plant's commercial dried aerial parts, by hydrodistillation, with different distillation times. The essential oils were analysed by gas chromatography and gas chromatography-mass spectrometry. The antioxidant ability was measured using a free radical scavenging activity assay using 2,2-diphenyl-1-picrylhydrazyl (DPPH), a thiobarbituric acid reactive substances (TBARS) assay, a deoxyribose assay for the scavenging of hydroxyl radical, an assay for site-specific actions and a 5-lipoxygenase assay. Antibacterial activity was determined by the agar diffusion method. 1,8-Cineole, α-pinene and camphor were the dominant components of all the essential oils. The different hydrodistillation times did not affect the oil yield nor the relative amount of the oil components. The time of hydrodistillation influenced the antioxidant activity. With the DPPH method, the oils isolated for 2 and 3 h were stronger free radical scavengers, while with the TBARS method, the highest antioxidant values were obtained in the oils isolated for 30 min, 2 and 3 h. Hydroxyl radical scavenging and lipoxygenase activity assays showed the best results with oils isolated for 1 and 3 h. With the deoxyribose method, sage oils at concentrations <1000 mg L(-1) showed better activity than mannitol. The essential oil of S. officinalis showed very weak antimicrobial activity. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21391115/Salvia_officinalis_L__essential_oils:_effect_of_hydrodistillation_time_on_the_chemical_composition_antioxidant_and_antimicrobial_activities_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2010.499513 DB - PRIME DP - Unbound Medicine ER -