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Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome.
Clin Exp Immunol. 2011 Apr; 164(1):100–7.CE

Abstract

Recurrent respiratory tract infections (RRTIs) are common clinical conditions in individuals with alterations of the immune function. A prospective open pilot study in a cohort of patients with RRTIs has been performed to assess whether sublingual immunization with a polyvalent bacterial vaccine could exert an immunomodulatory effect on the antigen-specific immunological responses and have an impact on the clinical outcome. Seventeen patients with RRTIs were recruited. An oral polyvalent bacterial preparation (Bactek®) was administered to all patients daily for 6 months. Immunological assessment was performed at baseline and at the end of immunization. Immunological measurements included: T cell-specific proliferations of CD3+CD4+ and CD3+CD8+ to Bactek® antigens, total immunoglobulin levels, antibodies to pneumococcal polysaccharide and tetanus toxoid and B, T and natural killer (NK) cell subsets. There was a significant increase in the proliferative capacity of CD3+CD4+ T cells specific to Bactek® antigens at month 6 in comparison to baseline (P < 0·0001). A significant increase in total CD3+ T cells was also observed (P < 0·05). No significant differences were observed between baseline and month 6 in levels of total immunoglobulins, specific antibodies and B, T or NK cell subsets. A significant reduction in the patient's rate of RRTIs was observed compared with 1 year prior to initiation of therapy (P < 0·0001). The results demonstrate that long-term administration of a sublingual polyvalent bacterial preparation in patients with RRTIs exerts an immune stimulating effect on CD4+ T helper cell responses to bacterial antigens which could be associated with clinical benefit.

Authors+Show Affiliations

Clinical Immunology Unit, Immunology, Department, Hospital General Universitario, Gregorio Marañón, Departamento de Microbiología I, Universidad Complutense de Madrid, Spain. dalecsan.hgugm@salud.madrid.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21391984

Citation

Alecsandru, D, et al. "Sublingual Therapeutic Immunization With a Polyvalent Bacterial Preparation in Patients With Recurrent Respiratory Infections: Immunomodulatory Effect On Antigen-specific Memory CD4+ T Cells and Impact On Clinical Outcome." Clinical and Experimental Immunology, vol. 164, no. 1, 2011, pp. 100–7.
Alecsandru D, Valor L, Sánchez-Ramón S, et al. Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome. Clin Exp Immunol. 2011;164(1):100–7.
Alecsandru, D., Valor, L., Sánchez-Ramón, S., Gil, J., Carbone, J., Navarro, J., Rodríguez, J., Rodríguez-Sainz, C., & Fernández-Cruz, E. (2011). Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome. Clinical and Experimental Immunology, 164(1), 100–7. https://doi.org/10.1111/j.1365-2249.2011.04320.x
Alecsandru D, et al. Sublingual Therapeutic Immunization With a Polyvalent Bacterial Preparation in Patients With Recurrent Respiratory Infections: Immunomodulatory Effect On Antigen-specific Memory CD4+ T Cells and Impact On Clinical Outcome. Clin Exp Immunol. 2011;164(1):100–7. PubMed PMID: 21391984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on antigen-specific memory CD4+ T cells and impact on clinical outcome. AU - Alecsandru,D, AU - Valor,L, AU - Sánchez-Ramón,S, AU - Gil,J, AU - Carbone,J, AU - Navarro,J, AU - Rodríguez,J, AU - Rodríguez-Sainz,C, AU - Fernández-Cruz,E, PY - 2011/3/12/entrez PY - 2011/3/12/pubmed PY - 2011/6/15/medline SP - 100–7 EP - 100–7 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 164 IS - 1 N2 - Recurrent respiratory tract infections (RRTIs) are common clinical conditions in individuals with alterations of the immune function. A prospective open pilot study in a cohort of patients with RRTIs has been performed to assess whether sublingual immunization with a polyvalent bacterial vaccine could exert an immunomodulatory effect on the antigen-specific immunological responses and have an impact on the clinical outcome. Seventeen patients with RRTIs were recruited. An oral polyvalent bacterial preparation (Bactek®) was administered to all patients daily for 6 months. Immunological assessment was performed at baseline and at the end of immunization. Immunological measurements included: T cell-specific proliferations of CD3+CD4+ and CD3+CD8+ to Bactek® antigens, total immunoglobulin levels, antibodies to pneumococcal polysaccharide and tetanus toxoid and B, T and natural killer (NK) cell subsets. There was a significant increase in the proliferative capacity of CD3+CD4+ T cells specific to Bactek® antigens at month 6 in comparison to baseline (P < 0·0001). A significant increase in total CD3+ T cells was also observed (P < 0·05). No significant differences were observed between baseline and month 6 in levels of total immunoglobulins, specific antibodies and B, T or NK cell subsets. A significant reduction in the patient's rate of RRTIs was observed compared with 1 year prior to initiation of therapy (P < 0·0001). The results demonstrate that long-term administration of a sublingual polyvalent bacterial preparation in patients with RRTIs exerts an immune stimulating effect on CD4+ T helper cell responses to bacterial antigens which could be associated with clinical benefit. SN - 1365-2249 UR - https://www.unboundmedicine.com/medline/citation/21391984/Sublingual_therapeutic_immunization_with_a_polyvalent_bacterial_preparation_in_patients_with_recurrent_respiratory_infections:_immunomodulatory_effect_on_antigen_specific_memory_CD4+_T_cells_and_impact_on_clinical_outcome_ L2 - https://doi.org/10.1111/j.1365-2249.2011.04320.x DB - PRIME DP - Unbound Medicine ER -