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Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients.
J Gastroenterol Hepatol. 2011 Jul; 26(7):1157-63.JG

Abstract

BACKGROUND AND AIM

Helicobacter pylori infection is a risk factor for gastric cancer. We evaluated whether H. pylori infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients.

METHODS

Young (age ≤ 40) gastric cancer patients (n = 185), their young siblings (n = 130), and young control participants (n = 287) were recruited. H. pylori infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of H. pylori infection and histological changes with gastric cancer using logistic regression analysis.

RESULTS

The H. pylori infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR]= 2.42, P = 0.001) or control participants (OR = 3.60, P < 0.001). In H. pylori-infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in H. pylori-infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher H. pylori infection rate (OR = 1.60, P = 0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR = 2.88, P =0.027) than control participants.

CONCLUSIONS

Even in young adults, H. pylori infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members.

Authors+Show Affiliations

Center for Cancer Prevention and Detection, National Cancer Center, Ilsandong-gu, Goyang, Gyeonggi, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

21392104

Citation

Nam, Ji Hyung, et al. "Helicobacter Pylori Infection and Histological Changes in Siblings of Young Gastric Cancer Patients." Journal of Gastroenterology and Hepatology, vol. 26, no. 7, 2011, pp. 1157-63.
Nam JH, Choi IJ, Cho SJ, et al. Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients. J Gastroenterol Hepatol. 2011;26(7):1157-63.
Nam, J. H., Choi, I. J., Cho, S. J., Kim, C. G., Lee, J. Y., Nam, S. Y., Park, S. R., Kook, M. C., Nam, B. H., & Kim, Y. W. (2011). Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients. Journal of Gastroenterology and Hepatology, 26(7), 1157-63. https://doi.org/10.1111/j.1440-1746.2011.06717.x
Nam JH, et al. Helicobacter Pylori Infection and Histological Changes in Siblings of Young Gastric Cancer Patients. J Gastroenterol Hepatol. 2011;26(7):1157-63. PubMed PMID: 21392104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection and histological changes in siblings of young gastric cancer patients. AU - Nam,Ji Hyung, AU - Choi,Il Ju, AU - Cho,Soo-Jeong, AU - Kim,Chan Gyoo, AU - Lee,Jong Yeul, AU - Nam,Su Youn, AU - Park,Sook Ryun, AU - Kook,Myeong-Cherl, AU - Nam,Byung-Ho, AU - Kim,Young-Woo, PY - 2011/3/12/entrez PY - 2011/3/12/pubmed PY - 2011/12/13/medline SP - 1157 EP - 63 JF - Journal of gastroenterology and hepatology JO - J Gastroenterol Hepatol VL - 26 IS - 7 N2 - BACKGROUND AND AIM: Helicobacter pylori infection is a risk factor for gastric cancer. We evaluated whether H. pylori infection and premalignant histological changes are more prevalent in siblings of young gastric cancer patients. METHODS: Young (age ≤ 40) gastric cancer patients (n = 185), their young siblings (n = 130), and young control participants (n = 287) were recruited. H. pylori infection and histological changes were assessed using the updated Sydney system in biopsy specimens from three regions. We analyzed the association of H. pylori infection and histological changes with gastric cancer using logistic regression analysis. RESULTS: The H. pylori infection rate was significantly higher in young cancer patients than their siblings (odds ratio [OR]= 2.42, P = 0.001) or control participants (OR = 3.60, P < 0.001). In H. pylori-infected subjects, corpus gastritis and premalignant changes of the corpus lesser curvature (LCv) were also more prevalent in patients than in siblings or controls. In terms of the antrum, intestinal metaplasia was more prevalent in H. pylori-infected patients than in siblings or controls, while atrophy was not affected. Siblings also had a higher H. pylori infection rate (OR = 1.60, P = 0.046) and higher prevalence of intestinal metaplasia at the corpus LCv (OR = 2.88, P =0.027) than control participants. CONCLUSIONS: Even in young adults, H. pylori infection is a risk factor for gastric cancer. Young adults with histological findings including corpus predominant gastritis, corpus atrophy, or intestinal metaplasia are at increased risk. Since young siblings share risk factors, screening and treatment should be considered for these family members. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/21392104/Helicobacter_pylori_infection_and_histological_changes_in_siblings_of_young_gastric_cancer_patients_ L2 - https://doi.org/10.1111/j.1440-1746.2011.06717.x DB - PRIME DP - Unbound Medicine ER -