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A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides.
Indian J Dermatol Venereol Leprol. 2011 Mar-Apr; 77(2):167-73.IJ

Abstract

BACKGROUND

Mycosis fungoides (MF) is cutaneous lymphoma of the T-cell lineage. Hypopigmented MF is a clinical variant of MF, described mainly in Asians. This is a retrospective clinicopathologic analysis of hypopigmented MF at a tertiary care center.

AIMS

To describe the clinicopathologic profile of hypopigmented MF.

METHODS

Records of clinicopathologic notes over a 5-year period ranging from January 2005 up to December 2009 were reviewed over a period of 3 months, of which 15 cases were diagnosed with hypopigmented MF based on clinicopathologic correlation.

RESULTS

Hypopigmented MF was found to be more common in males, and between second and fourth decades of life. The latent period between onset and diagnosis was around 3.83 years. Most of the patients were asymptomatic 80% (12/15), with skin changes of subtle atrophy in 46.66% (7/15), scaling in 20% (3/15) and focal changes of poikiloderma in 26.66% (4/15) patients. Most common sites of distribution of the lesions were the trunk and extremities. Many of the cases had been clinically mistaken for Hansen's disease prior to correct diagnosis. Marked epidermotropism and tagging of epidermis by large lymphocytes characterizes the condition histopathologically. Of the 15 cases, immunohistochemistry was possible in 10 cases, of which 8 showed predominant CD8 positive epidermotropic infiltrates and two cases showed absence of CD8 positive and CD4 positive lymphocytic infiltrate in the epidermis.

CONCLUSION

Hypopigmented MF presents as hypopigmented asymptomatic patches without any erythema or infiltration in its early stage and mimics Hansen's disease. Skin biopsy clinches the diagnosis.

Authors+Show Affiliations

Department of Dermatology, Seth GS Medical College and KEM Hospital, Parel, Mumbai-400 012, India. drkhopkar@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21393946

Citation

Khopkar, Uday, et al. "A Study of Clinicopathologic Profile of 15 Cases of Hypopigmented Mycosis Fungoides." Indian Journal of Dermatology, Venereology and Leprology, vol. 77, no. 2, 2011, pp. 167-73.
Khopkar U, Doshi BR, Dongre AM, et al. A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides. Indian J Dermatol Venereol Leprol. 2011;77(2):167-73.
Khopkar, U., Doshi, B. R., Dongre, A. M., & Gujral, S. (2011). A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides. Indian Journal of Dermatology, Venereology and Leprology, 77(2), 167-73. https://doi.org/10.4103/0378-6323.77456
Khopkar U, et al. A Study of Clinicopathologic Profile of 15 Cases of Hypopigmented Mycosis Fungoides. Indian J Dermatol Venereol Leprol. 2011 Mar-Apr;77(2):167-73. PubMed PMID: 21393946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of clinicopathologic profile of 15 cases of hypopigmented mycosis fungoides. AU - Khopkar,Uday, AU - Doshi,Bhavana R, AU - Dongre,Atul M, AU - Gujral,Sumeet, PY - 2011/3/12/entrez PY - 2011/3/12/pubmed PY - 2012/1/31/medline SP - 167 EP - 73 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 77 IS - 2 N2 - BACKGROUND: Mycosis fungoides (MF) is cutaneous lymphoma of the T-cell lineage. Hypopigmented MF is a clinical variant of MF, described mainly in Asians. This is a retrospective clinicopathologic analysis of hypopigmented MF at a tertiary care center. AIMS: To describe the clinicopathologic profile of hypopigmented MF. METHODS: Records of clinicopathologic notes over a 5-year period ranging from January 2005 up to December 2009 were reviewed over a period of 3 months, of which 15 cases were diagnosed with hypopigmented MF based on clinicopathologic correlation. RESULTS: Hypopigmented MF was found to be more common in males, and between second and fourth decades of life. The latent period between onset and diagnosis was around 3.83 years. Most of the patients were asymptomatic 80% (12/15), with skin changes of subtle atrophy in 46.66% (7/15), scaling in 20% (3/15) and focal changes of poikiloderma in 26.66% (4/15) patients. Most common sites of distribution of the lesions were the trunk and extremities. Many of the cases had been clinically mistaken for Hansen's disease prior to correct diagnosis. Marked epidermotropism and tagging of epidermis by large lymphocytes characterizes the condition histopathologically. Of the 15 cases, immunohistochemistry was possible in 10 cases, of which 8 showed predominant CD8 positive epidermotropic infiltrates and two cases showed absence of CD8 positive and CD4 positive lymphocytic infiltrate in the epidermis. CONCLUSION: Hypopigmented MF presents as hypopigmented asymptomatic patches without any erythema or infiltration in its early stage and mimics Hansen's disease. Skin biopsy clinches the diagnosis. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/21393946/A_study_of_clinicopathologic_profile_of_15_cases_of_hypopigmented_mycosis_fungoides_ L2 - http://www.ijdvl.com/article.asp?issn=0378-6323;year=2011;volume=77;issue=2;spage=167;epage=173;aulast=Khopkar DB - PRIME DP - Unbound Medicine ER -