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In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh.
Phytother Res. 2011 Oct; 25(10):1511-8.PR

Abstract

The purpose of this study was to analyse the major compound in the leaf essential oil of Cinnamomum osmophloeum Kaneh. and to examine its in vivo toxicity and cytokine-modulatory effects. The HS-GC/MS and quantitative HPLC analyses showed the concentrations of the major compounds, cinnamaldehyde, benzaldehyde and 3-phenylpropionaldehyde, in the leaf essential oil of Cinnamomum osmophloeum to be 16.88, 1.28 and 1.70 mg/mL, respectively. Acute and sub-acute toxicity tests identified no significant changes in body weight, liver and kidney function indices, and pathology for the mice treated with up to 1 mL/kg body weight of Cinnamomum osmophloeum leaf essential oil or up to 4 mg/kg body weight of cinnamaldehyde. A murine model was established using ovalbumin (OVA)-primed Balb/C mice treated with various concentrations of Cinnamomum osmophloeum leaf essential oil or cinnamaldehyde daily for 4 weeks. The results of tests with commercial ELISA kits indicated no significant cytokine-modulatory effects in mice treated with Cinnamomum osmophloeum leaf essential oil; however, the serum concentrations of IL-2, IL-4 and IL-10, but not IFN-γ, significantly increased in animals treated with 1 mg/kg body weight of cinnamaldehyde during the 4-week period. The possibility that the other constituents act as antagonists of cinnamaldehyde cannot be excluded.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lin SS
School of Dentistry, Chung Shang Medical University, Taichung, Taiwan, ROC.
Lu TM
No affiliation info available
Chao PC
No affiliation info available
Lai YY
No affiliation info available
Tsai HT
No affiliation info available
Chen CS
No affiliation info available
Lee YP
No affiliation info available
Chen SC
No affiliation info available
Chou MC
No affiliation info available
Yang CC
No affiliation info available

MeSH

AcroleinAldehydesAnimalsBenzaldehydesCinnamomumCytokinesFemaleImmunologic FactorsMiceMice, Inbred BALB CModels, AnimalOils, VolatileOvalbuminPlant ExtractsPlant Leaves

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21394803

Citation

Lin, Shih-Shen Chou, et al. "In Vivo Cytokine Modulatory Effects of Cinnamaldehyde, the Major Constituent of Leaf Essential Oil From Cinnamomum Osmophloeum Kaneh." Phytotherapy Research : PTR, vol. 25, no. 10, 2011, pp. 1511-8.
Lin SS, Lu TM, Chao PC, et al. In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh. Phytother Res. 2011;25(10):1511-8.
Lin, S. S., Lu, T. M., Chao, P. C., Lai, Y. Y., Tsai, H. T., Chen, C. S., Lee, Y. P., Chen, S. C., Chou, M. C., & Yang, C. C. (2011). In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh. Phytotherapy Research : PTR, 25(10), 1511-8. https://doi.org/10.1002/ptr.3419
Lin SS, et al. In Vivo Cytokine Modulatory Effects of Cinnamaldehyde, the Major Constituent of Leaf Essential Oil From Cinnamomum Osmophloeum Kaneh. Phytother Res. 2011;25(10):1511-8. PubMed PMID: 21394803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo cytokine modulatory effects of cinnamaldehyde, the major constituent of leaf essential oil from Cinnamomum osmophloeum Kaneh. AU - Lin,Shih-Shen Chou, AU - Lu,Tsong-Ming, AU - Chao,Pei-Chun, AU - Lai,Ya-Yun, AU - Tsai,Hsiu-Ting, AU - Chen,Chung-Shih, AU - Lee,Yi-Pang, AU - Chen,Shu-Chen, AU - Chou,Ming-Chih, AU - Yang,Chi-Chiang, Y1 - 2011/03/11/ PY - 2010/10/26/received PY - 2010/12/22/revised PY - 2011/01/03/accepted PY - 2011/3/12/entrez PY - 2011/3/12/pubmed PY - 2012/3/28/medline SP - 1511 EP - 8 JF - Phytotherapy research : PTR JO - Phytother Res VL - 25 IS - 10 N2 - The purpose of this study was to analyse the major compound in the leaf essential oil of Cinnamomum osmophloeum Kaneh. and to examine its in vivo toxicity and cytokine-modulatory effects. The HS-GC/MS and quantitative HPLC analyses showed the concentrations of the major compounds, cinnamaldehyde, benzaldehyde and 3-phenylpropionaldehyde, in the leaf essential oil of Cinnamomum osmophloeum to be 16.88, 1.28 and 1.70 mg/mL, respectively. Acute and sub-acute toxicity tests identified no significant changes in body weight, liver and kidney function indices, and pathology for the mice treated with up to 1 mL/kg body weight of Cinnamomum osmophloeum leaf essential oil or up to 4 mg/kg body weight of cinnamaldehyde. A murine model was established using ovalbumin (OVA)-primed Balb/C mice treated with various concentrations of Cinnamomum osmophloeum leaf essential oil or cinnamaldehyde daily for 4 weeks. The results of tests with commercial ELISA kits indicated no significant cytokine-modulatory effects in mice treated with Cinnamomum osmophloeum leaf essential oil; however, the serum concentrations of IL-2, IL-4 and IL-10, but not IFN-γ, significantly increased in animals treated with 1 mg/kg body weight of cinnamaldehyde during the 4-week period. The possibility that the other constituents act as antagonists of cinnamaldehyde cannot be excluded. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/21394803/In_vivo_cytokine_modulatory_effects_of_cinnamaldehyde_the_major_constituent_of_leaf_essential_oil_from_Cinnamomum_osmophloeum_Kaneh_ DB - PRIME DP - Unbound Medicine ER -