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Advanced protein glycation in psoriasis.
J Eur Acad Dermatol Venereol 2012; 26(2):172-9JE

Abstract

BACKGROUND

The aetiopathogenesis of psoriasis is very complex and has not been well known. Recently, it has been proposed that mechanisms dependent on free radicals may be involved in the development of this dermatosis. Also, psoriasis coincides with lipid disturbances, diabetes and diseases of cardiovascular system. However, the common mechanism connecting these diseases is still unknown.

OBJECTIVES

The aim of this study was to measure concentration of peptides containing glycated residues (AGE-peptides) and IgG, IgA and IgM antibodies against carboxymethyllysine (anti-CML) and carboxyethyllysine (anti-CEL) in the sera of patients at different phases of psoriasis activity in comparison with the sera of healthy individuals.

METHODS

The study material consisted of sera from psoriasis patients (n = 80) in active phase and in the remission phase and healthy individuals (n = 80) (controls). Concentrations of AGE-peptides were measured spectrofluorimetrically. Anti-CML and anti-CEL antibody concentrations were determined using ELISA.

RESULTS

In psoriasis patients in active phase disease concentrations of AGE-peptides and anti-CML and anti-CEL antibodies in all tested classes were significantly higher than those in healthy individuals. At remission, concentrations of AGE-peptides and tested antibodies decreased significantly, but concentrations of anti-CEL IgG and anti-CML IgG and IgM antibodies were remaining significantly higher in comparison with the control group.

CONCLUSION

The obtained results indicate for existence of increased oxidative stress in psoriasis and resulting increased protein glycation and stimulation of the immune system to response to these end-products. Increased protein glyco-oxidation consist a linker between psoriasis and increased prevalence of atherosclerosis, cardiovascular incidents and vascular complications of diabetes.

Authors+Show Affiliations

Department of Chemistry, Medical University of Silesia, Zabrze, Poland. olabodzek@interia.plNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21395695

Citation

Damasiewicz-Bodzek, A, and T Wielkoszyński. "Advanced Protein Glycation in Psoriasis." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 26, no. 2, 2012, pp. 172-9.
Damasiewicz-Bodzek A, Wielkoszyński T. Advanced protein glycation in psoriasis. J Eur Acad Dermatol Venereol. 2012;26(2):172-9.
Damasiewicz-Bodzek, A., & Wielkoszyński, T. (2012). Advanced protein glycation in psoriasis. Journal of the European Academy of Dermatology and Venereology : JEADV, 26(2), pp. 172-9. doi:10.1111/j.1468-3083.2011.04024.x.
Damasiewicz-Bodzek A, Wielkoszyński T. Advanced Protein Glycation in Psoriasis. J Eur Acad Dermatol Venereol. 2012;26(2):172-9. PubMed PMID: 21395695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced protein glycation in psoriasis. AU - Damasiewicz-Bodzek,A, AU - Wielkoszyński,T, Y1 - 2011/03/14/ PY - 2011/3/15/entrez PY - 2011/3/15/pubmed PY - 2012/5/15/medline SP - 172 EP - 9 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 26 IS - 2 N2 - BACKGROUND: The aetiopathogenesis of psoriasis is very complex and has not been well known. Recently, it has been proposed that mechanisms dependent on free radicals may be involved in the development of this dermatosis. Also, psoriasis coincides with lipid disturbances, diabetes and diseases of cardiovascular system. However, the common mechanism connecting these diseases is still unknown. OBJECTIVES: The aim of this study was to measure concentration of peptides containing glycated residues (AGE-peptides) and IgG, IgA and IgM antibodies against carboxymethyllysine (anti-CML) and carboxyethyllysine (anti-CEL) in the sera of patients at different phases of psoriasis activity in comparison with the sera of healthy individuals. METHODS: The study material consisted of sera from psoriasis patients (n = 80) in active phase and in the remission phase and healthy individuals (n = 80) (controls). Concentrations of AGE-peptides were measured spectrofluorimetrically. Anti-CML and anti-CEL antibody concentrations were determined using ELISA. RESULTS: In psoriasis patients in active phase disease concentrations of AGE-peptides and anti-CML and anti-CEL antibodies in all tested classes were significantly higher than those in healthy individuals. At remission, concentrations of AGE-peptides and tested antibodies decreased significantly, but concentrations of anti-CEL IgG and anti-CML IgG and IgM antibodies were remaining significantly higher in comparison with the control group. CONCLUSION: The obtained results indicate for existence of increased oxidative stress in psoriasis and resulting increased protein glycation and stimulation of the immune system to response to these end-products. Increased protein glyco-oxidation consist a linker between psoriasis and increased prevalence of atherosclerosis, cardiovascular incidents and vascular complications of diabetes. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/21395695/full_citation L2 - https://doi.org/10.1111/j.1468-3083.2011.04024.x DB - PRIME DP - Unbound Medicine ER -