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The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients.
Am Surg. 2011 Jan; 77(1):59-64.AS

Abstract

The objective of this study is to explore the inflammatory modulation effect of glutamine-enriched total parenteral nutrition (TPN) by investigating the alterations of inflammation-related cytokines in gastrointestinal (GI) cancer patients postoperatively. Fifty GI cancer patients received postoperative 7 days of isocaloric and isonitrogenous TPN after operation. They were randomly divided to receive either glutamine-enriched TPN or standard TPN. The inflammation-related cytokines including interleukin-6, interleukin-10, and tumor necrosis factor-α were also determined. Records of nutritional assessments, inflammatory status, and postoperative complications were compared between the two groups. Of 50 enrolled patients, 25 patients were classified as the intervention group, and the control group also comprised 25 patients. The differences of gender, age, primary GI malignancies, and hematological and biochemical data between the two compared groups were not statistically significant (all P > 0.05). Compared with standard TPN, a higher serum prealbumin level and better nitrogen balance were observed in glutamine-enriched TPN (P = 0.039 and 0.048 respectively). A significantly lower serum interleukin-6 level was found in comparing glutamine-enriched with standard TPN (P = 0.01), but not in interleukin-10 (P = 0.374) and tumor necrosis factor-α levels (P = 0.653). Moreover, a significant lower serum C-reactive protein level was detected in glutamine-enriched TPN compared with standard TPN (P = 0.013). Indeed, four cases of postoperative infectious complications were noted in the control group, but no postoperative infectious complications were observed in the interventional group (P = 0.037). Our present study shows that glutamine-enriched TPN may be beneficial in improving the inflammatory status and decreasing the infectious morbidity in postoperative GI cancer patients.

Authors+Show Affiliations

Lu CY
Nutrition Support Team, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Shih YL
No affiliation info available
Sun LC
No affiliation info available
Chuang JF
No affiliation info available
Ma CJ
No affiliation info available
Chen FM
No affiliation info available
Wu DC
No affiliation info available
Hsieh JS
No affiliation info available
Wang JY
No affiliation info available

MeSH

AgedC-Reactive ProteinCytokinesDigestive System Surgical ProceduresDouble-Blind MethodFemaleGastrointestinal NeoplasmsGlutamineHumansInflammationInflammation MediatorsInterleukin-10MaleMalnutritionMiddle AgedNutritional StatusParenteral Nutrition, TotalPostoperative CareQuality of LifeReference ValuesTreatment OutcomeWeight Gain

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21396307

Citation

Lu, Chien-Yu, et al. "The Inflammatory Modulation Effect of Glutamine-enriched Total Parenteral Nutrition in Postoperative Gastrointestinal Cancer Patients." The American Surgeon, vol. 77, no. 1, 2011, pp. 59-64.
Lu CY, Shih YL, Sun LC, et al. The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients. Am Surg. 2011;77(1):59-64.
Lu, C. Y., Shih, Y. L., Sun, L. C., Chuang, J. F., Ma, C. J., Chen, F. M., Wu, D. C., Hsieh, J. S., & Wang, J. Y. (2011). The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients. The American Surgeon, 77(1), 59-64.
Lu CY, et al. The Inflammatory Modulation Effect of Glutamine-enriched Total Parenteral Nutrition in Postoperative Gastrointestinal Cancer Patients. Am Surg. 2011;77(1):59-64. PubMed PMID: 21396307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The inflammatory modulation effect of glutamine-enriched total parenteral nutrition in postoperative gastrointestinal cancer patients. AU - Lu,Chien-Yu, AU - Shih,Ying-Ling, AU - Sun,Li-Chu, AU - Chuang,Jui-Fen, AU - Ma,Cheng-Jen, AU - Chen,Fang-Ming, AU - Wu,Deng-Chyang, AU - Hsieh,Jan-Sing, AU - Wang,Jaw-Yuan, PY - 2011/3/15/entrez PY - 2011/3/15/pubmed PY - 2011/6/4/medline SP - 59 EP - 64 JF - The American surgeon JO - Am Surg VL - 77 IS - 1 N2 - The objective of this study is to explore the inflammatory modulation effect of glutamine-enriched total parenteral nutrition (TPN) by investigating the alterations of inflammation-related cytokines in gastrointestinal (GI) cancer patients postoperatively. Fifty GI cancer patients received postoperative 7 days of isocaloric and isonitrogenous TPN after operation. They were randomly divided to receive either glutamine-enriched TPN or standard TPN. The inflammation-related cytokines including interleukin-6, interleukin-10, and tumor necrosis factor-α were also determined. Records of nutritional assessments, inflammatory status, and postoperative complications were compared between the two groups. Of 50 enrolled patients, 25 patients were classified as the intervention group, and the control group also comprised 25 patients. The differences of gender, age, primary GI malignancies, and hematological and biochemical data between the two compared groups were not statistically significant (all P > 0.05). Compared with standard TPN, a higher serum prealbumin level and better nitrogen balance were observed in glutamine-enriched TPN (P = 0.039 and 0.048 respectively). A significantly lower serum interleukin-6 level was found in comparing glutamine-enriched with standard TPN (P = 0.01), but not in interleukin-10 (P = 0.374) and tumor necrosis factor-α levels (P = 0.653). Moreover, a significant lower serum C-reactive protein level was detected in glutamine-enriched TPN compared with standard TPN (P = 0.013). Indeed, four cases of postoperative infectious complications were noted in the control group, but no postoperative infectious complications were observed in the interventional group (P = 0.037). Our present study shows that glutamine-enriched TPN may be beneficial in improving the inflammatory status and decreasing the infectious morbidity in postoperative GI cancer patients. SN - 1555-9823 UR - https://www.unboundmedicine.com/medline/citation/21396307/The_inflammatory_modulation_effect_of_glutamine_enriched_total_parenteral_nutrition_in_postoperative_gastrointestinal_cancer_patients_ L2 - https://medlineplus.gov/malnutrition.html DB - PRIME DP - Unbound Medicine ER -