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Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice.
Chemosphere. 2011 Jun; 84(1):124-30.C

Abstract

Cypermethrin (CYP) is one of the most common contaminants in the ecosystem. The effects of CYP exposure on the induction of oxidative stress and endocrine disruption were studied in adolescent male ICR mice. The hepatic activities of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and total antioxidant capacity (T-AOC) increased significantly after 3 weeks (postnatal day 21-42) of oral administration of 20 mg kg(-1) CYP. In accordance with the enzyme activities, the mRNA levels for the genes encoding these antioxidant proteins, such as Sod1, Sod2, Gpx1 and Gpx2, were also up-regulated significantly in the 10 and 20 mg kg(-1) CYP treatment groups. Furthermore, we also found that the 3-week oral administration of CYP decreased transcription levels of key genes in pathways of cholesterol synthesis and transport and testosterone synthesis including HMG-CoA synthase, steroidogenic acute regulatory protein (StAR) and cytochrome P450 17α-hydroxysteroid dehydrogenase (P450 17α in the liver and testes. Serum testosterone levels also decreased significantly in mice after treatment with 20 mg kg(-1) CYP. Taken together, the results indicated that CYP can induce endocrine disruption in adolescent mice. The findings will be helpful in elucidating the mechanism of toxicity induced by CYP in adolescent mice.

Authors+Show Affiliations

College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21397294

Citation

Jin, Yuanxiang, et al. "Cypermethrin Exposure During Puberty Induces Oxidative Stress and Endocrine Disruption in Male Mice." Chemosphere, vol. 84, no. 1, 2011, pp. 124-30.
Jin Y, Wang L, Ruan M, et al. Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice. Chemosphere. 2011;84(1):124-30.
Jin, Y., Wang, L., Ruan, M., Liu, J., Yang, Y., Zhou, C., Xu, B., & Fu, Z. (2011). Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice. Chemosphere, 84(1), 124-30. https://doi.org/10.1016/j.chemosphere.2011.02.034
Jin Y, et al. Cypermethrin Exposure During Puberty Induces Oxidative Stress and Endocrine Disruption in Male Mice. Chemosphere. 2011;84(1):124-30. PubMed PMID: 21397294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice. AU - Jin,Yuanxiang, AU - Wang,Linggang, AU - Ruan,Meili, AU - Liu,Jingwen, AU - Yang,Yuefeng, AU - Zhou,Cheng, AU - Xu,Bin, AU - Fu,Zhengwei, Y1 - 2011/03/11/ PY - 2010/08/14/received PY - 2011/01/13/revised PY - 2011/02/15/accepted PY - 2011/3/15/entrez PY - 2011/3/15/pubmed PY - 2011/7/30/medline SP - 124 EP - 30 JF - Chemosphere JO - Chemosphere VL - 84 IS - 1 N2 - Cypermethrin (CYP) is one of the most common contaminants in the ecosystem. The effects of CYP exposure on the induction of oxidative stress and endocrine disruption were studied in adolescent male ICR mice. The hepatic activities of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and total antioxidant capacity (T-AOC) increased significantly after 3 weeks (postnatal day 21-42) of oral administration of 20 mg kg(-1) CYP. In accordance with the enzyme activities, the mRNA levels for the genes encoding these antioxidant proteins, such as Sod1, Sod2, Gpx1 and Gpx2, were also up-regulated significantly in the 10 and 20 mg kg(-1) CYP treatment groups. Furthermore, we also found that the 3-week oral administration of CYP decreased transcription levels of key genes in pathways of cholesterol synthesis and transport and testosterone synthesis including HMG-CoA synthase, steroidogenic acute regulatory protein (StAR) and cytochrome P450 17α-hydroxysteroid dehydrogenase (P450 17α in the liver and testes. Serum testosterone levels also decreased significantly in mice after treatment with 20 mg kg(-1) CYP. Taken together, the results indicated that CYP can induce endocrine disruption in adolescent mice. The findings will be helpful in elucidating the mechanism of toxicity induced by CYP in adolescent mice. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/21397294/Cypermethrin_exposure_during_puberty_induces_oxidative_stress_and_endocrine_disruption_in_male_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-6535(11)00180-9 DB - PRIME DP - Unbound Medicine ER -