Tags

Type your tag names separated by a space and hit enter

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.
Lancet. 2011 Mar 26; 377(9771):1085-95.Lct

Abstract

BACKGROUND

Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease.

METHODS

We used individual records from 58 cohorts to calculate hazard ratios (HRs) per 1 SD higher baseline values (4.56 kg/m(2) higher BMI, 12.6 cm higher waist circumference, and 0.083 higher waist-to-hip ratio) and measures of risk discrimination and reclassification. Serial adiposity assessments were used to calculate regression dilution ratios.

RESULTS

Individual records were available for 221,934 people in 17 countries (14,297 incident cardiovascular disease outcomes; 1.87 million person-years at risk). Serial adiposity assessments were made in up to 63,821 people (mean interval 5.7 years [SD 3.9]). In people with BMI of 20 kg/m(2) or higher, HRs for cardiovascular disease were 1.23 (95% CI 1.17-1.29) with BMI, 1.27 (1.20-1.33) with waist circumference, and 1.25 (1.19-1.31) with waist-to-hip ratio, after adjustment for age, sex, and smoking status. After further adjustment for baseline systolic blood pressure, history of diabetes, and total and HDL cholesterol, corresponding HRs were 1.07 (1.03-1.11) with BMI, 1.10 (1.05-1.14) with waist circumference, and 1.12 (1.08-1.15) with waist-to-hip ratio. Addition of information on BMI, waist circumference, or waist-to-hip ratio to a cardiovascular disease risk prediction model containing conventional risk factors did not importantly improve risk discrimination (C-index changes of -0.0001, -0.0001, and 0.0008, respectively), nor classification of participants to categories of predicted 10-year risk (net reclassification improvement -0.19%, -0.05%, and -0.05%, respectively). Findings were similar when adiposity measures were considered in combination. Reproducibility was greater for BMI (regression dilution ratio 0.95, 95% CI 0.93-0.97) than for waist circumference (0.86, 0.83-0.89) or waist-to-hip ratio (0.63, 0.57-0.70).

INTERPRETATION

BMI, waist circumference, and waist-to-hip ratio, whether assessed singly or in combination, do not importantly improve cardiovascular disease risk prediction in people in developed countries when additional information is available for systolic blood pressure, history of diabetes, and lipids.

FUNDING

British Heart Foundation and UK Medical Research Council.

Authors+Show Affiliations

Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK. erfc@phpc.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21397319

Citation

Emerging Risk Factors Collaboration, et al. "Separate and Combined Associations of Body-mass Index and Abdominal Adiposity With Cardiovascular Disease: Collaborative Analysis of 58 Prospective Studies." Lancet (London, England), vol. 377, no. 9771, 2011, pp. 1085-95.
Emerging Risk Factors Collaboration, Wormser D, Kaptoge S, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet. 2011;377(9771):1085-95.
Wormser, D., Kaptoge, S., Di Angelantonio, E., Wood, A. M., Pennells, L., Thompson, A., Sarwar, N., Kizer, J. R., Lawlor, D. A., Nordestgaard, B. G., Ridker, P., Salomaa, V., Stevens, J., Woodward, M., Sattar, N., Collins, R., Thompson, S. G., Whitlock, G., & Danesh, J. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet (London, England), 377(9771), 1085-95. https://doi.org/10.1016/S0140-6736(11)60105-0
Emerging Risk Factors Collaboration, et al. Separate and Combined Associations of Body-mass Index and Abdominal Adiposity With Cardiovascular Disease: Collaborative Analysis of 58 Prospective Studies. Lancet. 2011 Mar 26;377(9771):1085-95. PubMed PMID: 21397319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. AU - ,, AU - Wormser,David, AU - Kaptoge,Stephen, AU - Di Angelantonio,Emanuele, AU - Wood,Angela M, AU - Pennells,Lisa, AU - Thompson,Alex, AU - Sarwar,Nadeem, AU - Kizer,Jorge R, AU - Lawlor,Debbie A, AU - Nordestgaard,Børge G, AU - Ridker,Paul, AU - Salomaa,Veikko, AU - Stevens,June, AU - Woodward,Mark, AU - Sattar,Naveed, AU - Collins,Rory, AU - Thompson,Simon G, AU - Whitlock,Gary, AU - Danesh,John, PY - 2011/3/15/entrez PY - 2011/3/15/pubmed PY - 2011/4/20/medline SP - 1085 EP - 95 JF - Lancet (London, England) JO - Lancet VL - 377 IS - 9771 N2 - BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease. METHODS: We used individual records from 58 cohorts to calculate hazard ratios (HRs) per 1 SD higher baseline values (4.56 kg/m(2) higher BMI, 12.6 cm higher waist circumference, and 0.083 higher waist-to-hip ratio) and measures of risk discrimination and reclassification. Serial adiposity assessments were used to calculate regression dilution ratios. RESULTS: Individual records were available for 221,934 people in 17 countries (14,297 incident cardiovascular disease outcomes; 1.87 million person-years at risk). Serial adiposity assessments were made in up to 63,821 people (mean interval 5.7 years [SD 3.9]). In people with BMI of 20 kg/m(2) or higher, HRs for cardiovascular disease were 1.23 (95% CI 1.17-1.29) with BMI, 1.27 (1.20-1.33) with waist circumference, and 1.25 (1.19-1.31) with waist-to-hip ratio, after adjustment for age, sex, and smoking status. After further adjustment for baseline systolic blood pressure, history of diabetes, and total and HDL cholesterol, corresponding HRs were 1.07 (1.03-1.11) with BMI, 1.10 (1.05-1.14) with waist circumference, and 1.12 (1.08-1.15) with waist-to-hip ratio. Addition of information on BMI, waist circumference, or waist-to-hip ratio to a cardiovascular disease risk prediction model containing conventional risk factors did not importantly improve risk discrimination (C-index changes of -0.0001, -0.0001, and 0.0008, respectively), nor classification of participants to categories of predicted 10-year risk (net reclassification improvement -0.19%, -0.05%, and -0.05%, respectively). Findings were similar when adiposity measures were considered in combination. Reproducibility was greater for BMI (regression dilution ratio 0.95, 95% CI 0.93-0.97) than for waist circumference (0.86, 0.83-0.89) or waist-to-hip ratio (0.63, 0.57-0.70). INTERPRETATION: BMI, waist circumference, and waist-to-hip ratio, whether assessed singly or in combination, do not importantly improve cardiovascular disease risk prediction in people in developed countries when additional information is available for systolic blood pressure, history of diabetes, and lipids. FUNDING: British Heart Foundation and UK Medical Research Council. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/21397319/Separate_and_combined_associations_of_body_mass_index_and_abdominal_adiposity_with_cardiovascular_disease:_collaborative_analysis_of_58_prospective_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(11)60105-0 DB - PRIME DP - Unbound Medicine ER -