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Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial.
J Endocrinol Invest. 2011 Sep; 34(8):e224-8.JE

Abstract

BACKGROUND

Several lines of evidence show the implication of oxidative stress in the etiology of male infertility. Recently, the role of coenzyme Q10 (CoQ10) in the prevention and treatment of disease has been intensively probed. However, definitive efficacy studies in oligoasthenoteratozoospermia (OAT) have not been completed yet.

AIM

To evaluate the effect of CoQ10 supplementation on semen parameters in idiopathic OAT (iOAT).

MATERIAL/SUBJECTS AND METHODS

A double-blind placebo controlled clinical trial was carried out. A total of 47 infertile men with iOAT were randomly assigned to receive 200 mg CoQ10 daily or placebo during a 12- week period. Semen parameters were determined using microscopic evaluation according to World Health Organization guidelines. Lipid peroxidation was assessed by measuring the concentration of plasma malondialdehyde. We evaluated the total antioxidant capacity of seminal plasma. To compare variables between and within the 2 groups we used independent t-test and Paired t-test.

RESULTS

The trial showed non-significant changes in semen parameters of CoQ10 group. However, concentrations of thiobarbituric acid-reactive substances were significantly (p<0.05) reduced in serum of treated groups compared with the control. Furthermore, total antioxidant capacity of seminal plasma significantly increased in the CoQ10 group (p<0.05).

CONCLUSION

Our results provide further evidence suggesting that CoQ10 supplementation is associated with alleviating oxidative stress, although it does not show any significant effects on sperm concentration, motility and morphology. It may be suggested that CoQ10 could be taken as an adjunct therapy in cases of OAT. Further studies are needed to draw a final conclusion.

Authors+Show Affiliations

Department of Nutrition, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21399391

Citation

Nadjarzadeh, A, et al. "Coenzyme Q10 Improves Seminal Oxidative Defense but Does Not Affect On Semen Parameters in Idiopathic Oligoasthenoteratozoospermia: a Randomized Double-blind, Placebo Controlled Trial." Journal of Endocrinological Investigation, vol. 34, no. 8, 2011, pp. e224-8.
Nadjarzadeh A, Sadeghi MR, Amirjannati N, et al. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J Endocrinol Invest. 2011;34(8):e224-8.
Nadjarzadeh, A., Sadeghi, M. R., Amirjannati, N., Vafa, M. R., Motevalian, S. A., Gohari, M. R., Akhondi, M. A., Yavari, P., & Shidfar, F. (2011). Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. Journal of Endocrinological Investigation, 34(8), e224-8. https://doi.org/10.3275/7572
Nadjarzadeh A, et al. Coenzyme Q10 Improves Seminal Oxidative Defense but Does Not Affect On Semen Parameters in Idiopathic Oligoasthenoteratozoospermia: a Randomized Double-blind, Placebo Controlled Trial. J Endocrinol Invest. 2011;34(8):e224-8. PubMed PMID: 21399391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. AU - Nadjarzadeh,A, AU - Sadeghi,M R, AU - Amirjannati,N, AU - Vafa,M R, AU - Motevalian,S A, AU - Gohari,M R, AU - Akhondi,M A, AU - Yavari,P, AU - Shidfar,F, Y1 - 2011/03/07/ PY - 2011/3/15/entrez PY - 2011/3/15/pubmed PY - 2012/5/5/medline SP - e224 EP - 8 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 34 IS - 8 N2 - BACKGROUND: Several lines of evidence show the implication of oxidative stress in the etiology of male infertility. Recently, the role of coenzyme Q10 (CoQ10) in the prevention and treatment of disease has been intensively probed. However, definitive efficacy studies in oligoasthenoteratozoospermia (OAT) have not been completed yet. AIM: To evaluate the effect of CoQ10 supplementation on semen parameters in idiopathic OAT (iOAT). MATERIAL/SUBJECTS AND METHODS: A double-blind placebo controlled clinical trial was carried out. A total of 47 infertile men with iOAT were randomly assigned to receive 200 mg CoQ10 daily or placebo during a 12- week period. Semen parameters were determined using microscopic evaluation according to World Health Organization guidelines. Lipid peroxidation was assessed by measuring the concentration of plasma malondialdehyde. We evaluated the total antioxidant capacity of seminal plasma. To compare variables between and within the 2 groups we used independent t-test and Paired t-test. RESULTS: The trial showed non-significant changes in semen parameters of CoQ10 group. However, concentrations of thiobarbituric acid-reactive substances were significantly (p<0.05) reduced in serum of treated groups compared with the control. Furthermore, total antioxidant capacity of seminal plasma significantly increased in the CoQ10 group (p<0.05). CONCLUSION: Our results provide further evidence suggesting that CoQ10 supplementation is associated with alleviating oxidative stress, although it does not show any significant effects on sperm concentration, motility and morphology. It may be suggested that CoQ10 could be taken as an adjunct therapy in cases of OAT. Further studies are needed to draw a final conclusion. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/21399391/Coenzyme_Q10_improves_seminal_oxidative_defense_but_does_not_affect_on_semen_parameters_in_idiopathic_oligoasthenoteratozoospermia:_a_randomized_double_blind_placebo_controlled_trial_ L2 - https://link.springer.com/article/10.3275/7572 DB - PRIME DP - Unbound Medicine ER -