Tags

Type your tag names separated by a space and hit enter

Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women.

Abstract

OBJECTIVE

To examine whether intake of ω-3 fatty acids and fish affects incidence of age-related macular degeneration (AMD) in women.

DESIGN

A detailed food-frequency questionnaire was administered at baseline among 39 876 female health professionals (mean [SD] age: 54.6 [7.0] years). A total of 38 022 women completed the questionnaire and were free of a diagnosis of AMD. The main outcome measure was incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review.

RESULTS

A total of 235 cases of AMD, most characterized by some combination of drusen and retinal pigment epithelial changes, were confirmed during an average of 10 years of follow-up. Women in the highest tertile of intake for docosahexaenoic acid, compared with those in the lowest, had a multivariate-adjusted relative risk of AMD of 0.62 (95% confidence interval, 0.44-0.87). For eicosapentaenoic acid, women in the highest tertile of intake had a relative risk of 0.66 (95% confidence interval, 0.48-0.92). Consistent with the findings for docosahexaenoic acid and eicosapentaenoic acid, women who consumed 1 or more servings of fish per week, compared with those who consumed less than 1 serving per month, had a relative risk of AMD of 0.58 (95% confidence interval, 0.38-0.87).

CONCLUSION

These prospective data from a large cohort of female health professionals without a diagnosis of AMD at baseline indicate that regular consumption of docosahexaenoic acid and eicosapentaenoic acid and fish was associated with a significantly decreased risk of incident AMD and may be of benefit in primary prevention of AMD.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA. wchristen@rics.bwh.harvard.edu

    , ,

    Source

    MeSH

    Diet
    Diet Surveys
    Double-Blind Method
    Fatty Acids, Omega-3
    Feeding Behavior
    Female
    Health Personnel
    Humans
    Incidence
    Macular Degeneration
    Middle Aged
    Prospective Studies
    Risk Assessment
    Seafood
    Surveys and Questionnaires
    United States
    Visual Acuity
    Women's Health

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    21402976

    Citation

    Christen, William G., et al. "Dietary Ω-3 Fatty Acid and Fish Intake and Incident Age-related Macular Degeneration in Women." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 129, no. 7, 2011, pp. 921-9.
    Christen WG, Schaumberg DA, Glynn RJ, et al. Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. Arch Ophthalmol. 2011;129(7):921-9.
    Christen, W. G., Schaumberg, D. A., Glynn, R. J., & Buring, J. E. (2011). Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. Archives of Ophthalmology (Chicago, Ill. : 1960), 129(7), pp. 921-9. doi:10.1001/archophthalmol.2011.34.
    Christen WG, et al. Dietary Ω-3 Fatty Acid and Fish Intake and Incident Age-related Macular Degeneration in Women. Arch Ophthalmol. 2011;129(7):921-9. PubMed PMID: 21402976.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. AU - Christen,William G, AU - Schaumberg,Debra A, AU - Glynn,Robert J, AU - Buring,Julie E, Y1 - 2011/03/14/ PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/9/2/medline SP - 921 EP - 9 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 129 IS - 7 N2 - OBJECTIVE: To examine whether intake of ω-3 fatty acids and fish affects incidence of age-related macular degeneration (AMD) in women. DESIGN: A detailed food-frequency questionnaire was administered at baseline among 39 876 female health professionals (mean [SD] age: 54.6 [7.0] years). A total of 38 022 women completed the questionnaire and were free of a diagnosis of AMD. The main outcome measure was incident AMD responsible for a reduction in best-corrected visual acuity to 20/30 or worse based on self-report confirmed by medical record review. RESULTS: A total of 235 cases of AMD, most characterized by some combination of drusen and retinal pigment epithelial changes, were confirmed during an average of 10 years of follow-up. Women in the highest tertile of intake for docosahexaenoic acid, compared with those in the lowest, had a multivariate-adjusted relative risk of AMD of 0.62 (95% confidence interval, 0.44-0.87). For eicosapentaenoic acid, women in the highest tertile of intake had a relative risk of 0.66 (95% confidence interval, 0.48-0.92). Consistent with the findings for docosahexaenoic acid and eicosapentaenoic acid, women who consumed 1 or more servings of fish per week, compared with those who consumed less than 1 serving per month, had a relative risk of AMD of 0.58 (95% confidence interval, 0.38-0.87). CONCLUSION: These prospective data from a large cohort of female health professionals without a diagnosis of AMD at baseline indicate that regular consumption of docosahexaenoic acid and eicosapentaenoic acid and fish was associated with a significantly decreased risk of incident AMD and may be of benefit in primary prevention of AMD. SN - 1538-3601 UR - https://www.unboundmedicine.com/medline/citation/21402976/Dietary_ω_3_fatty_acid_and_fish_intake_and_incident_age_related_macular_degeneration_in_women_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archophthalmol.2011.34 DB - PRIME DP - Unbound Medicine ER -