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High prevalence of hypovitaminosis D status in patients with early Parkinson disease.
Arch Neurol. 2011 Mar; 68(3):314-9.AN

Abstract

BACKGROUND

Vitamin D insufficiency has been reported to be more common in patients with Parkinson disease (PD) than in healthy control subjects, but it is not clear whether having a chronic disease causing reduced mobility contributes to this relatively high prevalence.

OBJECTIVE

To examine the prevalence of vitamin D insufficiency in a cohort of untreated patients with early PD (diagnosed within 5 years of study entry). DESIGN, SETTING, AND PATIENTS The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) cohort is a well-characterized cohort of subjects with early, nondisabling PD. The cohort is well suited for examining the prevalence of vitamin D insufficiency early in the course of the disease. We conducted a survey study of vitamin D status in stored blood samples from patients with PD enrolled in the placebo group of the DATATOP trial. Samples from baseline visits and end point/final visits (mean [SD], 18.9 [13.1] months) were analyzed for 25-hydroxyvitamin D (25[OH]D) concentration in blinded fashion.

MAIN OUTCOME MEASURES

The mean vitamin D concentration and the prevalence of vitamin D insufficiency at baseline and end point/final visits.

RESULTS

Among 199 subjects, 170 (85.4%) had samples from the baseline and end point visits available for analysis; 13 were excluded (10 with low probability of having PD and 3 with 25[OH]D concentrations>3 SDs above the mean). In the remaining 157 subjects, the mean (SD) 25(OH)D concentrations at the baseline and end point visits were 26.3 (8.6) ng/mL and 31.3 (9.0) ng/mL, respectively (to convert to nanomoles per liter, multiply by 2.496). The prevalence of vitamin D insufficiency (25[OH]D concentration<30.0 ng/mL) was 69.4% at baseline and 51.6% at the end point.

CONCLUSIONS

The prevalence of vitamin D insufficiency in patients with early PD was similar to or higher than those reported in previous studies. Vitamin D concentrations did not decline during progression of PD. Further studies are needed to elucidate the natural history and significance of vitamin D insufficiency in PD.

Authors+Show Affiliations

Department of Neurology, Emory University School of Medicine, 1841 Clifton Rd NE, Atlanta, GA 30329, USA. mevatt@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21403017

Citation

Evatt, Marian L., et al. "High Prevalence of Hypovitaminosis D Status in Patients With Early Parkinson Disease." Archives of Neurology, vol. 68, no. 3, 2011, pp. 314-9.
Evatt ML, DeLong MR, Kumari M, et al. High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Arch Neurol. 2011;68(3):314-9.
Evatt, M. L., DeLong, M. R., Kumari, M., Auinger, P., McDermott, M. P., & Tangpricha, V. (2011). High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Archives of Neurology, 68(3), 314-9. https://doi.org/10.1001/archneurol.2011.30
Evatt ML, et al. High Prevalence of Hypovitaminosis D Status in Patients With Early Parkinson Disease. Arch Neurol. 2011;68(3):314-9. PubMed PMID: 21403017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of hypovitaminosis D status in patients with early Parkinson disease. AU - Evatt,Marian L, AU - DeLong,Mahlon R, AU - Kumari,Meena, AU - Auinger,Peggy, AU - McDermott,Michael P, AU - Tangpricha,Vin, AU - ,, PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/5/20/medline SP - 314 EP - 9 JF - Archives of neurology JO - Arch Neurol VL - 68 IS - 3 N2 - BACKGROUND: Vitamin D insufficiency has been reported to be more common in patients with Parkinson disease (PD) than in healthy control subjects, but it is not clear whether having a chronic disease causing reduced mobility contributes to this relatively high prevalence. OBJECTIVE: To examine the prevalence of vitamin D insufficiency in a cohort of untreated patients with early PD (diagnosed within 5 years of study entry). DESIGN, SETTING, AND PATIENTS The Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) cohort is a well-characterized cohort of subjects with early, nondisabling PD. The cohort is well suited for examining the prevalence of vitamin D insufficiency early in the course of the disease. We conducted a survey study of vitamin D status in stored blood samples from patients with PD enrolled in the placebo group of the DATATOP trial. Samples from baseline visits and end point/final visits (mean [SD], 18.9 [13.1] months) were analyzed for 25-hydroxyvitamin D (25[OH]D) concentration in blinded fashion. MAIN OUTCOME MEASURES: The mean vitamin D concentration and the prevalence of vitamin D insufficiency at baseline and end point/final visits. RESULTS: Among 199 subjects, 170 (85.4%) had samples from the baseline and end point visits available for analysis; 13 were excluded (10 with low probability of having PD and 3 with 25[OH]D concentrations>3 SDs above the mean). In the remaining 157 subjects, the mean (SD) 25(OH)D concentrations at the baseline and end point visits were 26.3 (8.6) ng/mL and 31.3 (9.0) ng/mL, respectively (to convert to nanomoles per liter, multiply by 2.496). The prevalence of vitamin D insufficiency (25[OH]D concentration<30.0 ng/mL) was 69.4% at baseline and 51.6% at the end point. CONCLUSIONS: The prevalence of vitamin D insufficiency in patients with early PD was similar to or higher than those reported in previous studies. Vitamin D concentrations did not decline during progression of PD. Further studies are needed to elucidate the natural history and significance of vitamin D insufficiency in PD. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/21403017/High_prevalence_of_hypovitaminosis_D_status_in_patients_with_early_Parkinson_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneurol.2011.30 DB - PRIME DP - Unbound Medicine ER -