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[Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain].
Gan To Kagaku Ryoho. 2011 Mar; 38(3):415-8.GT

Abstract

BACKGROUND

The administration of opioids to outpatients with cancer pain can be difficult because the constant dose modification and treatments of side effects involved are occasionally impossible. Therefore, more effective and safer drugs with better patients compliance are needed to complete a successful opioid introduction. Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence. Further more, compliance can be improved because the drug is a patch,administered transdermally.

METHODS

Between July 2008 and December 2009, we investigated the safety and analgesic effect of a fentanyl patch (2.1 mg) as a direct opioid introduction for 36 outpatients with cancer pain without titrations of other opioids.

RESULTS

Side effects of constipation, nausea, somnolence, and dizziness were observed in 17 (47%), 6 (17%), 4 (11%), and 3 (8%) patients, respectively, and no respiratory suppression was observed. Regarding the analgesic effect, 23 (64%) patients reported improvement on pain scales one week after the initiation of the fentanyl patch.

CONCLUSIONS

Opioid introduction to opioid-naÏve outpatients with cancer pain using the low-dose fentanyl patch (2.1 mg) may be effective.

Authors+Show Affiliations

Hata A
Division of Integrated Oncology, Institute of Biomedical Research and Innovation, Japan.
Katakami N
No affiliation info available
Masuda Y
No affiliation info available
Nanjo S
No affiliation info available
Otsuka K
No affiliation info available
Kaji R
No affiliation info available
Fujita S
No affiliation info available
Iwamori S
No affiliation info available
Mifune Y
No affiliation info available
Orita H
No affiliation info available
Fukae M
No affiliation info available
Yamatani T
No affiliation info available

MeSH

AdultAgedAged, 80 and overAnalgesics, OpioidConstipationFemaleFentanylHumansMaleMiddle AgedNeoplasmsOutpatientsPainPain MeasurementTransdermal PatchVomiting

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

21403444

Citation

Hata, Akito, et al. "[Direct Low-dose Fentanyl Patch (2.1mg) Introduction for Opioid Naïve Outpatients With Cancer Pain]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 38, no. 3, 2011, pp. 415-8.
Hata A, Katakami N, Masuda Y, et al. [Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. Gan To Kagaku Ryoho. 2011;38(3):415-8.
Hata, A., Katakami, N., Masuda, Y., Nanjo, S., Otsuka, K., Kaji, R., Fujita, S., Iwamori, S., Mifune, Y., Orita, H., Fukae, M., & Yamatani, T. (2011). [Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 38(3), 415-8.
Hata A, et al. [Direct Low-dose Fentanyl Patch (2.1mg) Introduction for Opioid Naïve Outpatients With Cancer Pain]. Gan To Kagaku Ryoho. 2011;38(3):415-8. PubMed PMID: 21403444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Direct low-dose fentanyl patch (2.1mg) introduction for opioid naïve outpatients with cancer pain]. AU - Hata,Akito, AU - Katakami,Nobuyuki, AU - Masuda,Yoshio, AU - Nanjo,Shigeki, AU - Otsuka,Kyoko, AU - Kaji,Reiko, AU - Fujita,Shiro, AU - Iwamori,Shigeo, AU - Mifune,Yuka, AU - Orita,Hiromi, AU - Fukae,Michiyo, AU - Yamatani,Toshiyuki, PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/4/22/medline SP - 415 EP - 8 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 38 IS - 3 N2 - BACKGROUND: The administration of opioids to outpatients with cancer pain can be difficult because the constant dose modification and treatments of side effects involved are occasionally impossible. Therefore, more effective and safer drugs with better patients compliance are needed to complete a successful opioid introduction. Compared with other opioids, low-dose fentanyl has been suggested to produce milder side effects such as nausea, constipation, and somnolence. Further more, compliance can be improved because the drug is a patch,administered transdermally. METHODS: Between July 2008 and December 2009, we investigated the safety and analgesic effect of a fentanyl patch (2.1 mg) as a direct opioid introduction for 36 outpatients with cancer pain without titrations of other opioids. RESULTS: Side effects of constipation, nausea, somnolence, and dizziness were observed in 17 (47%), 6 (17%), 4 (11%), and 3 (8%) patients, respectively, and no respiratory suppression was observed. Regarding the analgesic effect, 23 (64%) patients reported improvement on pain scales one week after the initiation of the fentanyl patch. CONCLUSIONS: Opioid introduction to opioid-naÏve outpatients with cancer pain using the low-dose fentanyl patch (2.1 mg) may be effective. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/21403444/[Direct_low_dose_fentanyl_patch__2_1mg__introduction_for_opioid_naïve_outpatients_with_cancer_pain]_ DB - PRIME DP - Unbound Medicine ER -