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Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies.
Eur J Cancer Prev. 2011 Jul; 20(4):287-92.EJ

Abstract

To evaluate the association between coffee, decaffeinated coffee, and tea consumption and pancreatic cancer risk in a pooled analysis of two Italian case-control studies, between 1983 and 2008, we conducted two case-control studies in Northern Italy, including a total of 688 pancreatic cancer cases and 2204 hospital controls with acute, non-neoplastic diseases. We computed multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for coffee drinking (mostly espresso and mocha), adjusting for age, sex, center, year of interview, education, body mass index, tobacco smoking, alcohol drinking, and diabetes. Compared with coffee nondrinkers, the multivariate OR for coffee drinkers was 1.34 (95% CI: 1.01-1.77). However, there was no trend in risk with respect to dose and duration. The OR for an increment of one cup per day was 1.05 (95% CI: 0.98-1.11). There was no heterogeneity in strata of age, sex, and other covariates, including tobacco smoking. No association emerged for decaffeinated coffee (for drinkers the OR was 0.87, 95% CI: 0.60-1.26, compared with decaffeinated coffee nondrinkers) or tea (for tea drinkers the OR was 0.92, 95% CI: 0.75-1.14). The lack of relationship with dose and duration weighs against a causal association between coffee and pancreatic cancer, which is in agreement with most evidence on the issue.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Dipartimento di Medicina del Lavoro, Università degli Studi di Milano, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21403521

Citation

Turati, Federica, et al. "Coffee, Decaffeinated Coffee, Tea, and Pancreatic Cancer Risk: a Pooled-analysis of Two Italian Case-control Studies." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 20, no. 4, 2011, pp. 287-92.
Turati F, Galeone C, Talamini R, et al. Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies. Eur J Cancer Prev. 2011;20(4):287-92.
Turati, F., Galeone, C., Talamini, R., Franceschi, S., Manzari, M., Gallino, G., Polesel, J., La Vecchia, C., & Tavani, A. (2011). Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 20(4), 287-92. https://doi.org/10.1097/CEJ.0b013e32834572e7
Turati F, et al. Coffee, Decaffeinated Coffee, Tea, and Pancreatic Cancer Risk: a Pooled-analysis of Two Italian Case-control Studies. Eur J Cancer Prev. 2011;20(4):287-92. PubMed PMID: 21403521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee, decaffeinated coffee, tea, and pancreatic cancer risk: a pooled-analysis of two Italian case-control studies. AU - Turati,Federica, AU - Galeone,Carlotta, AU - Talamini,Renato, AU - Franceschi,Silvia, AU - Manzari,Marco, AU - Gallino,Gianfrancesco, AU - Polesel,Jerry, AU - La Vecchia,Carlo, AU - Tavani,Alessandra, PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/9/29/medline SP - 287 EP - 92 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 20 IS - 4 N2 - To evaluate the association between coffee, decaffeinated coffee, and tea consumption and pancreatic cancer risk in a pooled analysis of two Italian case-control studies, between 1983 and 2008, we conducted two case-control studies in Northern Italy, including a total of 688 pancreatic cancer cases and 2204 hospital controls with acute, non-neoplastic diseases. We computed multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for coffee drinking (mostly espresso and mocha), adjusting for age, sex, center, year of interview, education, body mass index, tobacco smoking, alcohol drinking, and diabetes. Compared with coffee nondrinkers, the multivariate OR for coffee drinkers was 1.34 (95% CI: 1.01-1.77). However, there was no trend in risk with respect to dose and duration. The OR for an increment of one cup per day was 1.05 (95% CI: 0.98-1.11). There was no heterogeneity in strata of age, sex, and other covariates, including tobacco smoking. No association emerged for decaffeinated coffee (for drinkers the OR was 0.87, 95% CI: 0.60-1.26, compared with decaffeinated coffee nondrinkers) or tea (for tea drinkers the OR was 0.92, 95% CI: 0.75-1.14). The lack of relationship with dose and duration weighs against a causal association between coffee and pancreatic cancer, which is in agreement with most evidence on the issue. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/21403521/Coffee_decaffeinated_coffee_tea_and_pancreatic_cancer_risk:_a_pooled_analysis_of_two_Italian_case_control_studies_ L2 - http://dx.doi.org/10.1097/CEJ.0b013e32834572e7 DB - PRIME DP - Unbound Medicine ER -