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Dietary fat intake and risk of breast cancer: a case-control study in China.

Abstract

The association between consumption of fat and specific types of fat and the risk of breast cancer has been examined in previous studies, but the results remain unclear. Moreover, few studies were conducted in China, where dietary habits are different from those of the Western countries. We conducted a hospital-based case-control study from June 2007 to August 2008 among Chinese women residing in Guangdong to investigate the associations of dietary fat and specific types of fat with the risk of breast cancer. Four hundred and thirty-eight consecutively recruited cases with primary breast cancer were frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). Detailed dietary intake information was assessed by face-to-face interviews with a validated Food Frequency Questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from multiple unconditional logistic regression models controlling for nondietary and dietary potential confounders. Total fat intake was not associated with the risk of breast cancer after adjustment for various confounding variables (OR = 0.82, 95% CI = 0.50-1.32, Ptrend = 0.739). Intakes of saturated fat, monounsaturated fat, n-3 polyunsaturated fat, and n-6 polyunsaturated fat were also not significantly associated with breast cancer risk. However, consumption of polyunsaturated fat was observed to be associated with a significantly lower risk of breast cancer. Compared with the lowest quartile, the adjusted OR in the highest quartile was 0.50 (95% CI = 0.27-0.93, Ptrend = 0.034). This study suggested that intakes of total fat, saturated and monounsaturated fat, n-3 and n-6 polyunsaturated fat were not associated with risk of breast cancer, but that polyunsaturated fat decreased the risk.

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  • Authors+Show Affiliations

    ,

    Centre of Research and Promotion of Women's Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, PR China.

    , , , ,

    Source

    MeSH

    Adult
    Aged
    Breast Neoplasms
    Case-Control Studies
    China
    Dietary Fats
    Female
    Humans
    Middle Aged
    Risk Factors
    Rural Population
    Survival Rate
    Urban Population

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21403522

    Citation

    Zhang, Cai-Xia, et al. "Dietary Fat Intake and Risk of Breast Cancer: a Case-control Study in China." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 20, no. 3, 2011, pp. 199-206.
    Zhang CX, Ho SC, Lin FY, et al. Dietary fat intake and risk of breast cancer: a case-control study in China. Eur J Cancer Prev. 2011;20(3):199-206.
    Zhang, C. X., Ho, S. C., Lin, F. Y., Chen, Y. M., Cheng, S. Z., & Fu, J. H. (2011). Dietary fat intake and risk of breast cancer: a case-control study in China. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 20(3), pp. 199-206. doi:10.1097/CEJ.0b013e32834572bb.
    Zhang CX, et al. Dietary Fat Intake and Risk of Breast Cancer: a Case-control Study in China. Eur J Cancer Prev. 2011;20(3):199-206. PubMed PMID: 21403522.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat intake and risk of breast cancer: a case-control study in China. AU - Zhang,Cai-Xia, AU - Ho,Suzanne C, AU - Lin,Fang-Yu, AU - Chen,Yu-Ming, AU - Cheng,Shou-Zhen, AU - Fu,Jian-Hua, PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/7/29/medline SP - 199 EP - 206 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 20 IS - 3 N2 - The association between consumption of fat and specific types of fat and the risk of breast cancer has been examined in previous studies, but the results remain unclear. Moreover, few studies were conducted in China, where dietary habits are different from those of the Western countries. We conducted a hospital-based case-control study from June 2007 to August 2008 among Chinese women residing in Guangdong to investigate the associations of dietary fat and specific types of fat with the risk of breast cancer. Four hundred and thirty-eight consecutively recruited cases with primary breast cancer were frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). Detailed dietary intake information was assessed by face-to-face interviews with a validated Food Frequency Questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from multiple unconditional logistic regression models controlling for nondietary and dietary potential confounders. Total fat intake was not associated with the risk of breast cancer after adjustment for various confounding variables (OR = 0.82, 95% CI = 0.50-1.32, Ptrend = 0.739). Intakes of saturated fat, monounsaturated fat, n-3 polyunsaturated fat, and n-6 polyunsaturated fat were also not significantly associated with breast cancer risk. However, consumption of polyunsaturated fat was observed to be associated with a significantly lower risk of breast cancer. Compared with the lowest quartile, the adjusted OR in the highest quartile was 0.50 (95% CI = 0.27-0.93, Ptrend = 0.034). This study suggested that intakes of total fat, saturated and monounsaturated fat, n-3 and n-6 polyunsaturated fat were not associated with risk of breast cancer, but that polyunsaturated fat decreased the risk. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/21403522/Dietary_fat_intake_and_risk_of_breast_cancer:_a_case_control_study_in_China_ L2 - http://Insights.ovid.com/pubmed?pmid=21403522 DB - PRIME DP - Unbound Medicine ER -