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Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis.

Abstract

Many in-vitro and animal studies have provided evidence that tea has many possible anticarcinogenic mechanisms, but epidemiological evidence for the effect of tea consumption on the primary liver cancer risk remains controversial and, to date, there have been no quantitative meta-analyses reported regarding this topic. The aim of this meta-analysis is to evaluate the association between tea consumption and the risk of primary liver cancer from case-control and cohort studies. Epidemiological studies of tea consumption in relation to primary liver cancer were identified by searching MEDLINE, EMBASE, Chinese Bio-medicine Database, and Chinese Wanfang Database, from January 1979 to December 2009. The language of publication was restricted to English and Chinese. Heterogeneity and publication bias were evaluated and the pooled relative risks (RRs) were calculated using a fixed-effect model. A random-effect model was used when statistically significant heterogeneity existed. All data analyses were carried out using R software and the package 'meta'. A total of 13 epidemiological studies consisting of six case-control and seven prospective cohort studies were included. An inverse association with a borderline significance [RR = 0.77; 95% confidence interval (CI) = 0.57-1.03] was found between tea consumption and primary liver cancer. The studies with higher quality showed a similar finding with pooled RR of 0.79 (95% CI = 0.61-1.01). Both men (RR = 0.86; 95% CI = 0.77-0.95) and women (RR = 0.54; 95% CI = 0.37-0.79) showed the preventive effects of tea intake on the development of primary liver cancer. Eight studies conducted on green tea consumption suggested that it was associated with a moderate reduction in risk for primary liver cancer (RR = 0.79; 95% CI = 0.68-0.93). No publication bias was found either from funnel plot visualization or the Egger-weighted regression (P value = 0.34) and the Begg rank correlation (P value = 0.12) methods. These results provide more evidence for a protective effect of tea consumption against the development of primary liver cancer. More well-conducted and large-scale epidemiological studies are needed.

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  • Authors+Show Affiliations

    ,

    Department of Biology, Formation and Research Unit of Sciences and Technology, University Claude Bernard Lyon 1, Lyon, France.

    , , ,

    Source

    MeSH

    Beverages
    Case-Control Studies
    Cohort Studies
    Epidemiologic Studies
    Female
    Humans
    Incidence
    Liver Neoplasms
    Male
    Risk Factors
    Survival Rate
    Tea
    United States

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    21403523

    Citation

    Fon Sing, Mélanie, et al. "Epidemiological Studies of the Association Between Tea Drinking and Primary Liver Cancer: a Meta-analysis." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 20, no. 3, 2011, pp. 157-65.
    Fon Sing M, Yang WS, Gao S, et al. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev. 2011;20(3):157-65.
    Fon Sing, M., Yang, W. S., Gao, S., Gao, J., & Xiang, Y. B. (2011). Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 20(3), pp. 157-65. doi:10.1097/CEJ.0b013e3283447497.
    Fon Sing M, et al. Epidemiological Studies of the Association Between Tea Drinking and Primary Liver Cancer: a Meta-analysis. Eur J Cancer Prev. 2011;20(3):157-65. PubMed PMID: 21403523.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. AU - Fon Sing,Mélanie, AU - Yang,Wan-Shui, AU - Gao,Shan, AU - Gao,Jing, AU - Xiang,Yong-Bing, PY - 2011/3/16/entrez PY - 2011/3/16/pubmed PY - 2011/7/29/medline SP - 157 EP - 65 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 20 IS - 3 N2 - Many in-vitro and animal studies have provided evidence that tea has many possible anticarcinogenic mechanisms, but epidemiological evidence for the effect of tea consumption on the primary liver cancer risk remains controversial and, to date, there have been no quantitative meta-analyses reported regarding this topic. The aim of this meta-analysis is to evaluate the association between tea consumption and the risk of primary liver cancer from case-control and cohort studies. Epidemiological studies of tea consumption in relation to primary liver cancer were identified by searching MEDLINE, EMBASE, Chinese Bio-medicine Database, and Chinese Wanfang Database, from January 1979 to December 2009. The language of publication was restricted to English and Chinese. Heterogeneity and publication bias were evaluated and the pooled relative risks (RRs) were calculated using a fixed-effect model. A random-effect model was used when statistically significant heterogeneity existed. All data analyses were carried out using R software and the package 'meta'. A total of 13 epidemiological studies consisting of six case-control and seven prospective cohort studies were included. An inverse association with a borderline significance [RR = 0.77; 95% confidence interval (CI) = 0.57-1.03] was found between tea consumption and primary liver cancer. The studies with higher quality showed a similar finding with pooled RR of 0.79 (95% CI = 0.61-1.01). Both men (RR = 0.86; 95% CI = 0.77-0.95) and women (RR = 0.54; 95% CI = 0.37-0.79) showed the preventive effects of tea intake on the development of primary liver cancer. Eight studies conducted on green tea consumption suggested that it was associated with a moderate reduction in risk for primary liver cancer (RR = 0.79; 95% CI = 0.68-0.93). No publication bias was found either from funnel plot visualization or the Egger-weighted regression (P value = 0.34) and the Begg rank correlation (P value = 0.12) methods. These results provide more evidence for a protective effect of tea consumption against the development of primary liver cancer. More well-conducted and large-scale epidemiological studies are needed. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/21403523/Epidemiological_studies_of_the_association_between_tea_drinking_and_primary_liver_cancer:_a_meta_analysis_ L2 - http://Insights.ovid.com/pubmed?pmid=21403523 DB - PRIME DP - Unbound Medicine ER -